Virology 10: Herpes

Front 1

herpes structure (3)

Back 1

dsDNA
icosahedral capsid
envelope

Front 2

herpes virus types (8)

Back 2

1. HSV1
2. HSV2
3. VZV
4. EBV
5. CMV
6. HHV6
7. HHV7
8. KSHV

Front 3

HSV1 and HSV2 differ in (3)

Back 3

biochemical properties
biological properties
antigenic structure

Front 4

during primary HSV infection, proliferation of ___ (2) occurs

Back 4

local tissue
nerve endings

Front 5

antibodies are present ___ after infection, but do not ___

Back 5

4--8 days
prevent reactivation

Front 6

in a virion, the herpes genome is ___. as a latent infection, the genome is ___

Back 6

linear
circular

Front 7

T/F: primary HSV infections are always severe

Back 7

false: often asymptomatic

Front 8

when herpes is latent ___ (2) are expressed, but they do not ___

Back 8

LAT1
LAT2
make protein

Front 9

causes for reactivation (4)

Back 9

fever
hormonal change
stress
UV radiation

Front 10

___ is a rare complication of herpes with ___% mortality if not treated quickly with ___

Back 10

encephalitis
70
acyclovir

Front 11

neonatal HSV infection is usually caused by ___. in this case, it is particularly severe because ___, to prevent transmission, do ___

Back 11

maternal primary HSV infection at time of delivery
maternal Igs aren't available to deliver to baby
C section

Front 12

herpes is usually cultured on ___. this allows ___ (2) assays

Back 12

fibroblast culture
CPE
immunofluorescence

Front 13

diagnostic techniques (3)

Back 13

enriching in cell culture
ELISA for herpes Ag
PCR

Front 14

VZV can cause ___. It is the only ___ herpesvirus.

Back 14

pneumonia
airborne

Front 15

unlike HSV, VZV has ___ before ___

Back 15

viremia phase
skin infection

Front 16

incubation for VZV is about ___ days

Back 16

14

Front 17

chickenpox infection course (6)

Back 17

1. droplets land on nasal mucosa
2. virions penetrate epithelium
3. virions spread via blood and lymphatics to organs
4. virions multiply in organs
5. virions reenter blood
6. virions go to skin and cause lesions

Front 18

the threshold for VZV reactivation is higher/lower than for HSV

Back 18

higher

Front 19

vaccination is for ___ and works by ___

Back 19

prevention of herpes zoster
strengthening immune memory

Front 20

EBV symptoms (5)

Back 20

fever
lymphadenopathy
hepatitis
respiratory
atypical lymphocytes

Front 21

rarely, EBV causes

Back 21

CNS symptoms

Front 22

EBV infects ___ (2) cells

Back 22

epithelial
B

Front 23

B cells are ___ for EBV

Back 23

semipermissive

Front 24

in epithelial cells EBV is ___ and ___, but in B cells it's ___ and ___

Back 24

productive
lytic
latent
immortalizing

Front 25

when EBV is latent in a B cells it's a ___. the antigens produced during this phase are ___ (2)

Back 25

episome
EA
EBNA

Front 26

EBNA-1 triggers

Back 26

replication of EBV genome

Front 27

T/F immunodeficiency is required for EBV reactivation

Back 27

false

Front 28

___ (2) are serology markers for current infection
___ is a marker for past infection

Back 28

anti VCA IgM
anti EA IgM
anti-EBNA IgG

Front 29

EBV associated neoplasms (4)

Back 29

Burkitt's lymphoma
nasopharyngeal carcinoma
post-transplantation lymphoproliferative disease (PTLD)

Front 30

CMV causes ___ (2)

Back 30

teratogenesis
infections in immunocompromised

Front 31

___ are especially vulnerable to in utero infections, because ___

Back 31

premies
they don't get maternal IgA

Front 32

CMV causes ___ in immunocompromised people

Back 32

pneumonitis
gastroenteritis
encephalitis
retinitis

Front 33

___ (2) recipients are susceptible to CMV infection

Back 33

bone marrow transplant
kidney transplant

Front 34

drugs (2) for CMV
because of ___ it should only be given if there is ___

Back 34

ganciclovir
valganciclovir
side effects
ongoing CMV replication

Front 35

diagnosis of CMV (3)

Back 35

serology (IgM)
PCR
pp65 antigenemia