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22 Cards in this Set
- Front
- Back
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mechanisms of activation of oncogenes (5)
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transduction by retroviruses
insertional mutagenesis translocation amplification mutation |
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retroviruses which do transduction
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rous sarcoma virus
feline sarcoma virus avian myoblastosis virus avian melocytoma virus |
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T/F: insertion of the provirus must be upstream of proto-oncogene to activate it.
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false
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___ is a proto-oncogene activated by insertional activation and translocation
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myc
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In general, ___ activate oncogenes and ___ deactivate tumor suppressors.
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RNA viruses
DNA viruses |
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___ all deactivate p53. The first ___ are DNA viruses.
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HPV
adenovirus HCV 2 |
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___ viruses are innocuous and do not cause transformation. ___ viruses can cause transformation.
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endogenous
exogneous |
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kinds of transforming viruses (3)
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rapidly transforming
cis activating slowly transforming trans activating slowly transforming |
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___ is a rapidly transforming virus. it acts via ___.
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rous sarcoma virus
src |
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___ is a cis-activating slowly transforming virus. it acts via ___.
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avian leukemia virus
c-myc |
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rapidly transforming viruses have ___. they cause tumors in ___ weeks
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oncogenes in their genome
2--4 |
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___ is a trans-activating slowly transformiing virus. it acts via ___ and causes ___
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HTLV
Tax ATL |
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slowly transforming viruses do not ___
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have oncogenes in their genome
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In contrast to RNA viruses, oncogenic DNA viruses' oncogenes ___ (3)
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are required for viral replication
have no cellular homolog rarely cause tumors in normal host |
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DNA tumor virus families (5)
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papova
adeno herpes hepadna pox |
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HPV oncogenic proteins (3)
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E5
E6 E7 |
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E5 does
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cross links YKR
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E6 does
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p53 inhibition
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E7 does
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Rb inhibition
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adenovirus oncogenic proteins (2)
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E1A
E1B |
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E1A does
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Rb inhibition
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E1B does
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p53 inhibition
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