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22 Cards in this Set

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  • Back
mechanisms of activation of oncogenes (5)
transduction by retroviruses
insertional mutagenesis
translocation
amplification
mutation
retroviruses which do transduction
rous sarcoma virus
feline sarcoma virus
avian myoblastosis virus
avian melocytoma virus
T/F: insertion of the provirus must be upstream of proto-oncogene to activate it.
false
___ is a proto-oncogene activated by insertional activation and translocation
myc
In general, ___ activate oncogenes and ___ deactivate tumor suppressors.
RNA viruses
DNA viruses
___ all deactivate p53. The first ___ are DNA viruses.
HPV
adenovirus
HCV
2
___ viruses are innocuous and do not cause transformation. ___ viruses can cause transformation.
endogenous
exogneous
kinds of transforming viruses (3)
rapidly transforming
cis activating slowly transforming
trans activating slowly transforming
___ is a rapidly transforming virus. it acts via ___.
rous sarcoma virus
src
___ is a cis-activating slowly transforming virus. it acts via ___.
avian leukemia virus
c-myc
rapidly transforming viruses have ___. they cause tumors in ___ weeks
oncogenes in their genome
2--4
___ is a trans-activating slowly transformiing virus. it acts via ___ and causes ___
HTLV
Tax
ATL
slowly transforming viruses do not ___
have oncogenes in their genome
In contrast to RNA viruses, oncogenic DNA viruses' oncogenes ___ (3)
are required for viral replication
have no cellular homolog
rarely cause tumors in normal host
DNA tumor virus families (5)
papova
adeno
herpes
hepadna
pox
HPV oncogenic proteins (3)
E5
E6
E7
E5 does
cross links YKR
E6 does
p53 inhibition
E7 does
Rb inhibition
adenovirus oncogenic proteins (2)
E1A
E1B
E1A does
Rb inhibition
E1B does
p53 inhibition