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21 Cards in this Set
- Front
- Back
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late proteins are synthesized after ___
examples include (2) |
DNA replication
glycoproteins for envelope enzymes packaged with virion |
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___ (3) are dsDNA viruses which replicate in nucleus
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papovaviridae
adenoviridae herpesviridae |
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___ is a dsDNA virus which replicates in cytoplasm
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poxviridae
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___ is an early protein
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75k DNA binding protein
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poxvirus enters cell by binding ___ and ___ing
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EGFR
being endocytosed |
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pox needs ___ (3) from the host cell
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ribosomes
membranes small precursors |
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pox virus factories are visible as ___
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inclusion bodies
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early pox genes are expressed in ___
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the (partially uncoated) core particle
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early pox proteins do: (3)
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inhibition of DNA and protein synthes
transcriptional regulation DNA replication |
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adenovirus structure
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naked icosahedron
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___ cells are permissive for adenovirus, but can't be transformed by it. ___ cells are restrictive, but can.
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human
rodent |
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adenovirus E1A causes transformation by
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binding Rb, causing release of E2F
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adenovirus causes host-cell shutdown by ___ing the CBP. The CBP is necessary for ___, because ___. this doesn't affect viral mRNA because ___.
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dephosphorylating
translation of host mRNA host mRNA has tertiary structure in 3'-noncoding region don't have tertiary structure in 3'-noncoding region |
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compared to other dsDNA viruses, herpes ___s less
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depends on cellular enzymes
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late herpes proteins inhibit ___
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expression of early genes
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herpes structure
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naked icosahedron
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acyclovir activity depends on ___. for this reason its active only in cells where ___
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phosphorylation by viral thymidine kinase
virus is active |
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alpha proteins are aka ___ and do ___ (2)
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immediate early proteins
regulation of transcription (transcription factors) cell takeover |
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beta proteins are aka ___ and do (2)
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early proteins
transcription factors DNA pol |
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gamma proteins are aka ___ and are
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late proteins
viral structural proteins |
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ribonucleotide reductase is important for herpes to ___ in ___ cells
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synthesize DNA
non-dividing |
