Virology 02: Replication

Front 1

steps in replication cycle (7)

Back 1

1. adhesion
2. penetration
3. uncoating
4. gene expression
5. replication
6. assembly and maturation
7. release of progeny

Front 2

in reproductive cycle, there is net loss of virions in the ___ and ___ phases, and gain of virions in the ___ phase

Back 2

eclipse
inactivation
maturation

Front 3

3 kinds of viral infections

Back 3

productive
abortive
restrictive

Front 4

productive infection is where ___ and occurs in ___

Back 4

new virions are made
permissive cells

Front 5

abortive infection is where ___ or ___. in the second case, the cell is ___

Back 5

virus is defective
cells don't allow full viral gene expression
non-permissive

Front 6

restrictive infection is where ___ or ___

Back 6

cell is transiently permissive
only a subpopulation of cells is permissive

Front 7

T/F: only productive infections cause oncogenic transformation

Back 7

false

Front 8

___ is an example of a virus with receptors for multiple surface ligands. this means it has ___

Back 8

influenza
many potential hosts

Front 9

receptor for HIV is ___ on ___ cells

Back 9

CD4
T

Front 10

receptor for EBV is ___ on ___ cells

Back 10

CD21
B

Front 11

receptor for measles is ___

Back 11

CD46

Front 12

receptor for rabies is ___

Back 12

AChR

Front 13

receptor for pox (vaccinia) is ___

Back 13

EGFR

Front 14

receptor for human rhinovirus is ___

Back 14

ICAM-1

Front 15

like rhinovirus, the receptor for polio is a ___

Back 15

Ig-like molecule

Front 16

rhinovirus and poliovirus are called

Back 16

picornaviruses

Front 17

T/F: different viruses can share a receptor, and different strains of the same virus can use different receptors

Back 17

true!

Front 18

T/F: attachment is usually energy and temperature dependent

Back 18

false

Front 19

whereas attachment is energy-___, penetration is energy-___

Back 19

independent
dependent

Front 20

enveloped viruses can enter cell via ___ (2). nonenveloped viruses can enter a cell via ___

Back 20

fusion
endocytosis
translocation
endocytosis

Front 21

only ___ viruses which replicate in ___ can use cellular transcriptases

Back 21

DNA
nucleus

Front 22

eukaryotic translation is ___, which means ___

Back 22

monocistronic
1 mRNA makes 1 polypeptide

Front 23

3 goals of viral genes

Back 23

1. replication of genome
2. packaging of genome
3. interfering with structure and function of host cell

Front 24

not all viruses encode their own genes for ___, but all viruses encode genes for ___.

Back 24

replication of genome
packaging genome into virions

Front 25

class I viruses

Back 25

dsDNA

Front 26

class II viruses

Back 26

+ sense ssDNA

Front 27

class III viruses

Back 27

dsRNA

Front 28

class IV viruses

Back 28

+ sense ssRNA

Front 29

class V viruses

Back 29

- sense ssRNA

Front 30

class VI viruses

Back 30

+ sense ssRNA with DNA intermediate

Front 31

class VII viruses

Back 31

dsDNA with RNA intermediate

Front 32

examples of class I viruses (4)

Back 32

papova
adeno
herpes
hepadna

Front 33

example of class III viruses

Back 33

reo (rota)

Front 34

examples of class IV viruses (2)

Back 34

picorna
heparna

Front 35

examples of nonsegmented class V viruses (2)

Back 35

rhabdo (rabies)
filo (ebola)

Front 36

examples of segmented class V viruses

Back 36

orthomyxo (influenza)

Front 37

example of class VI viruses

Back 37

retro