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17 Cards in this Set
- Front
- Back
- 3rd side (hint)
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What is baltimore class 1 characterized by?
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double stranded DNA viruses
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What is baltimore class 2 characterized by?
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single stranded DNA
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What is baltimore class 3 characterized by?
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double stranded RNA viruses
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What is baltimore class 4 characterized by?
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-single stranded RNA
-sense strand (+) |
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What is baltimore class 5 characterized by?
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-single stranded RNA
-sense strand (-) |
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What is baltimore class 6 characterized by?
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-single stranded RNA
-reverse transcriptase (RNA>>DNA>>RNA) -Sense strand (+) -two copies E.g. HIV |
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What is baltimore class 7 characterized by?
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double stranded DNA
Reversetranscriptase (DNA>>RNA>>DNA) Icosahedral Enveloped -circle gapped Family: Hepadna |
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Classification of Polio Virus
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-class 4: RNA, ss, (+)
-icosahedral -naked! Family Name: Picorna |
Morphological Changes upon infection: Nuclear Shrinking, proliferation of membrane.
Incubation period: 5-20 |
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Classification of Rubella Virus
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-class 4: RNA, ss, (+)
-icosahedral -enveloped Family Name: Toga Aka German Measles |
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Classification of Ebola Virus
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-class 5: RNA, ss, (-)
-helical -enveloped Family Name: Filo |
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Classification of Measles Virus
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-class 5: RNA, ss, (-)
-helical -enveloped (pH Independent) Family Name: Paramyxo |
Form syncytia (cell to cell fusion >>> single cell)
Severe Measles Sequelae : SSPE ~1 per 1E6 cases |
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Classification of Small Pox Virus
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-class 1: DNA, ds ***covalently joined ends
-undergoes concatamer resolution -Symetry: complex -enveloped (cytoplasmic) Family Name: Pox |
Morphological Changes: Creates Factories (guarnieri bodies) in the cytoplasm
**Can cause cancer (shope fibroma) Incubation Period 12-14 Days |
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Three Inhibitory Roles of Ab's during Viral Infection of a Cell.
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1. Block binding to a receptor
2. Can Block endocytosis or fusion event. 3. Can block release of genome into the cell. |
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4 Methods of Viral Suppression of Host Immune Response
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1. Inhibition of humoral immunity:
Mech: Virus produces complement protein Result: Inhibits complement activation. 2. Inhibition of inflammatory response Mech: Produces Viral cytokine receptor Result: blocks cellular cytokine action 3. Blocking of Ag processing and presentation. Mech: Inhibition of MHC1 expression Result: inhibits CTL recognition of cell and thereby cell mediated apoptosis 4. Immunosuppression of host. Mech: Produces viral homolog to IL-10 Result: Inhibits TH1 response (cell mediated: destruction of Ag in vacuoles) |
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Polio Virus Life Cycle:
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1. attachment
2. uncoating 3. translation 4. protein processing (P1: structural proteins for virus capsid [VP0, VP1, VP3]; P2/P3 protein synthesis proteins for replication) 5. (-) RNA strand synthesis 6. (+) RNA strand synthesis a. Early in Infection: makes lots of copies of the original positive strand which undergo protein processing b. Late in Infection: products enter morphogenesis portion of cycle and are packaged into virions 7. Translation 8. Morphogenesis: Provirion (formed by Structural proteins and positive strand RNA)→Virion 9. Release from cell by lysis |
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Killed Polio Vaccine Pros And Cons
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Pros:
-virus is inactivated and can therefore be used in immunosuppressed individuals -provides systemic immunity Cons: -intramuscular injection w/ repeated doses -expensive -potential hazard of exposure during production -reduced intestinal immunity |
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Live Polio Vaccine Pros and Cons
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Pros:
-systemic and intestinal immunity generated -inexpensive and easily administer (oral) -herd immunity Cons: -mutates to neurovirulent form. -not appropriate for immunosuppressed individuals -those poor monkeys |
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