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14 Cards in this Set
- Front
- Back
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Influenza virus and rotovirus are examples of
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localized virus
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Measles virus
HIV Hepatitis viruses are examples of |
systemic virus
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Rabies virus
Poliovirus West Nile virus Herpes simplex virus are examples of |
neurotropic virus
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What do viruses have to do at the site of entry?
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replicate
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What is the most common point of entry?
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respiratory virus like influenza
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What is required of an insect vetor virus?
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Requires virus replication in arthropod vector and mamalian host
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What is responsible for disease symptoms, e.g., respiratory viruses – rhinitis, pharyngitis, laryngitis, etc.
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localized infection
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What may be either asymptomatic = “incubation period” (e.g., rabies virus, HIV) or result in “nonspecific” symptoms = “prodromal symptoms” (e.g., measles virus)
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systemic infection
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What is the most important distinction between localized and systemic infections?
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Virus spread from site of entry to other tissues
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What are the two major routes of spread with a systemic infection?
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1) viremia
2) neural spread |
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What usually involves spread of virus to draining lymph nodes and replication in immune cells, that then traffic to other sites – spleen, liver, etc.
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viremia
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What is involved with when the virus enters neurons at one synaptic junction, replicates in cell body, and is released at the next synaptic junction (e.g., rabies virus, reactivated herpes simplex virus).
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neural spread
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What are the steps of a systemic viral infection?
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1) Virus Entry
2) Virus replication at site of entry Asymptomatic = “incubation period” Nonspecific symptoms = “prodrome” 3) Virus spread Viremia or Neural spread 4) Virus replication in target organs 5) Recovery |
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Virus replication in “target” organs leads to “specific” symptoms of disease:
1) Liver 2) Capillary endothelium and skin 3) Capillary endothelium and many organs 4) Heart 5) Lymphoid organs 6) CNS |
1) Hepitis
2) Rash (exantham) 3) Hemorragic fever 4) Myocarditis 5) Immunodeficiency 6) Encephalitis or menigitis |
