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14 Cards in this Set

  • Front
  • Back
Influenza virus and rotovirus are examples of
localized virus
Measles virus
HIV
Hepatitis viruses are examples of
systemic virus
Rabies virus
Poliovirus
West Nile virus
Herpes simplex virus are examples of
neurotropic virus
What do viruses have to do at the site of entry?
replicate
What is the most common point of entry?
respiratory virus like influenza
What is required of an insect vetor virus?
Requires virus replication in arthropod vector and mamalian host
What is responsible for disease symptoms, e.g., respiratory viruses – rhinitis, pharyngitis, laryngitis, etc.
localized infection
What may be either asymptomatic = “incubation period” (e.g., rabies virus, HIV) or result in “nonspecific” symptoms = “prodromal symptoms” (e.g., measles virus)
systemic infection
What is the most important distinction between localized and systemic infections?
Virus spread from site of entry to other tissues
What are the two major routes of spread with a systemic infection?
1) viremia
2) neural spread
What usually involves spread of virus to draining lymph nodes and replication in immune cells, that then traffic to other sites – spleen, liver, etc.
viremia
What is involved with when the virus enters neurons at one synaptic junction, replicates in cell body, and is released at the next synaptic junction (e.g., rabies virus, reactivated herpes simplex virus).
neural spread
What are the steps of a systemic viral infection?
1) Virus Entry
2) Virus replication at site of entry
Asymptomatic = “incubation period”
Nonspecific symptoms = “prodrome”
3) Virus spread
Viremia or Neural spread
4) Virus replication in target organs
5) Recovery
Virus replication in “target” organs leads to “specific” symptoms of disease:
1) Liver
2) Capillary endothelium and skin
3) Capillary endothelium and many organs
4) Heart
5) Lymphoid organs
6) CNS
1) Hepitis
2) Rash (exantham)
3) Hemorragic fever
4) Myocarditis
5) Immunodeficiency
6) Encephalitis or menigitis