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31 Cards in this Set
- Front
- Back
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Most common cause of viral gastroenteritis?
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Rotavirus
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Other viral causes of gastroenteritis?
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Caliciviruses
Noroviruses Sapoviruses Enteric Adenovirus Astrovirus |
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Another word for sporadic?
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endemic
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Example of endemic viral gastroenteritis cause?
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rotavirus in kids
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Ex. of epidemic viral gastroenteritis cause?
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Norovirus in older kids and adults
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ROTAVIRUS
Appearance |
large WHEEL!
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ROTAVIRUS
kicker for genetics? |
SEGMENTED ds RNA virus--> different types
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ROTAVIRUS
groups that affect humans |
A
B C |
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ROTAVIRUS
Outer vs Inner Capsid proteins |
Outer: VP4 & VP7
Inner: VP6 |
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ROTAVIRUS
pathogenesis |
Infects enterocytes of villous epithelium in jejunum and duodenum-->
Blunting of villi, necrosis, sloughing, etc. |
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ROTAVIRUS
Diarrhea results from? |
Loss of BB enzymes
NSP4 toxin --> secretory poo ENS activation --> more motile |
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how long until we no longer recover virus in poo?
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on avg, 1 week
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how does our immune system lead us to recovery?
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virus specific secretory IgA
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Kicker about recovery?
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IT COMES BACK! but often B and T memory lessens the severity of the recurrences.
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ROTAVIRUS
Appearance of poo |
watery or yellow without mucous or blood (rice water?)
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ROTAVIRUS
Dx |
Culture: not so much
Immune or Nucleic Acid based tests are the best ELISA (detects VP^6), PCR (for VP4 and VP7) |
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ROTAVIRUS
Rx |
Replace fluids and electrolytes
Avoid Antibiotics or antimotility agents |
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HUMAN CALICIVIRUSES
pathology |
Highly infectious: 1 viron may cause disease
Causes "epidemics" |
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HUMAN CALICIVIRUSES
transmission? |
Fecal-Oral Route
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NOROVIRUS Epidemics
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CRUISE SHIPS! and restaurants
Causes lots of food-related illness (oysters) |
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NOROVIRUS
incubation |
24-48 hours
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NOROVIRUS
Presentation |
Acute onset of abd cramps and/or nausea
Kids: more vomiting Adults: more pooing Systemic Symptoms in 50% |
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NOROVIRUS
recovery time? |
48-72 hours
Immunity occurs but is not long lasting |
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CALICIVIRUS
Dx |
Stool-no blood, no mucus, no WBC's
PCR and immunoassays |
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CALICIVIRUS
Rx |
fluid and electrolytes
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Enteric Adenoviruses
usually? |
usually cause respiratory problems, BUT can cause endemic gastroenteritis too
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ENTERIC ADENOVIRUSES
Incubation and disease duration |
Incubation: 8-10 days
Illness Duration: 5-12 days |
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ASTROVIRUSES
causes? transmission |
causes endemic GE
F-O route |
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Who are the viruses that infect the GI Tract but cause disease elsewhere too?
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ENTEROVIRUSES
polioviruses Coxsackieviruses echoviruses enteroviruses |
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ENTEROVIRUSES
seasonal? |
summer and early fall
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ENTEROVIRUS
Tx |
F-O, but also resp
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