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11 Cards in this Set
- Front
- Back
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Brain pathology without inflammation such as that seen in Alzheimer's disease and subacute spongifom diseases is termed?
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Encephalopathy
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What are the two ways by which viruses can enter the CNS?
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Crossing the BBB (hematogenous entry)
Travel up peripheral or olfactory nerves (neural entry) |
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What functional area of the brain is affected during herpes encephalitis?
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Frontal and temporal lobes.
Produces psychoses, bizarre behavior and hallucinations. |
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True or false.
CNS infections alter peripheral leukocyte levels. |
False, they may not but the CSF during the infection contains elevated leukocyte, erythrocyte and protein levels.
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Both arenaviruses and bunyaviruses have spherical, enveloped particles with SEGMENTED RNA genomes. Describe the differences between both virions.
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Arenaviruses have two segments (L and S)
Bunyaviruses have three segments (L, M,S) |
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Key Concept
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Some animal viruses can persist in their "natural" animal hosts without causing any symptoms. When the animal virus is accidentally transmitted to humans, a SYMPTOMATIC, sometimes lethal infection can occur.
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What antiviral is useful for arenaviruses? Bunyaviruses?
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Ribavirin for arenas.
There are none for bunyas. |
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After a dog bite from a rabid dog, when does the symptoms of a rabies infection occur?
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Primary replication occurs at the site of inoculation for 18-60 days. Neurotropism then occurs. Symptoms begin when the virus enters the CNS.
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What are the three forms of measles encephalitis?
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Acute postinfectious encephalitis- postulated autoimmune reaction against brain tissue
Acute progressive infectious encephalitis- nonrestricted virus replication due to the absence of normal cell-immunity (occurs in IC patients). SSPE-progressive dissemination of a defective virus infection in the presence of a normal immune response. |
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What are the two subacute spongiform encephalopathies?
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Kuru
Cruetzfeld-Jakob Disease Note:both diseases clinically manifest as presenile dementias. |
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True or False.
Inflammation or immune responses are not observed in this disease. |
True.
Spongiform pathology and amyloid plaque formation in the CNS are typical. |
