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28 Cards in this Set
- Front
- Back
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What is the bird flu?
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1)infuenza virus
2)Enveloped, negative strand RNA 3)Classification within groups based on two proteins in the envelope. |
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What are the two proteins used for classification within groups?
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Hemaglutinin
Neuraminidase |
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What is anitgenic drift?
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Small genomes changes and resulting host defense resistance. Changes in the H or N gene that are suitably small not to result in host changes.
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What is antigenic shift?
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large genome changes and resulting in host change.
ex: HiNi-->HsNi |
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How does one become infected with the bird flu?
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1)Aquired through respiration
2)Attachment to ciliary epithelium in respiratory tracts -Neruraminidase degrades mucin in resp. tract(saloic Acid. -Hemaglutinin specifically interacts with host cel membrane receptors. |
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What does Neuraminidase do?
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degrades mucin in resp. tract.
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What does Hemaglutinin do?
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Interacts with host cell membrane receptors.
->inward buldgin of host membrane ->formation of endosome ->drop in pH and uncoating of virus nucleic acid ->release into cytoplasm. |
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What happens in the nucleus?
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The negative strand is made inte mRNA by viral polymerase and mRNA is used for packaging.
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What happens in the cytoplasm?
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mRNA is used for
1)viral capsid proteins 2)HA 3)NA |
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HA and NA then go to the ??
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Endoplasmic reticulum and then to the golgi and then to host cytomembrane.
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What are the symptoms of the bird flu?
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Fever, chills bc of death of respiratory epitheial cells.
(extensive budding from envelope; T-Cell attack on infected host cell) |
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How does the bird flu virus hop into humans?
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1)occasionally a mutant bird flu virus may be transmitted to a human host.
2)Close proximity of animals and humans. |
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Why should we in the US care?
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1)Bird migratory routes-shared
2)Bird feces may carry the virus |
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What are the treatments for bird flu?
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1)Drugs to block release of virus from host cytoplasmic membrane.
-"trapped viruses"->cannot infect other cells and the spread of virus within the host is slowed. |
|
|
What is the bird flu?
|
1)infuenza virus
2)Enveloped, negative strand RNA 3)Classification within groups based on two proteins in the envelope. |
|
|
What are the two proteins used for classification within groups?
|
Hemaglutinin
Neuraminidase |
|
|
What is anitgenic drift?
|
Small genomes changes and resulting host defense resistance. Changes in the H or N gene that are suitably small not to result in host changes.
|
|
|
What is antigenic shift?
|
large genome changes and resulting in host change.
ex: HiNi-->HsNi |
|
|
How does one become infected with the bird flu?
|
1)Aquired through respiration
2)Attachment to ciliary epithelium in respiratory tracts -Neruraminidase degrades mucin in resp. tract(saloic Acid. -Hemaglutinin specifically interacts with host cel membrane receptors. |
|
|
What does Neuraminidase do?
|
degrades mucin in resp. tract.
|
|
|
What does Hemaglutinin do?
|
Interacts with host cell membrane receptors.
->inward buldgin of host membrane ->formation of endosome ->drop in pH and uncoating of virus nucleic acid ->release into cytoplasm. |
|
|
What happens in the nucleus?
|
The negative strand is made inte mRNA by viral polymerase and mRNA is used for packaging.
|
|
|
What happens in the cytoplasm?
|
mRNA is used for
1)viral capsid proteins 2)HA 3)NA |
|
|
HA and NA then go to the ??
|
Endoplasmic reticulum and then to the golgi and then to host cytomembrane.
|
|
|
What are the symptoms of the bird flu?
|
Fever, chills bc of death of respiratory epitheial cells.
(extensive budding from envelope; T-Cell attack on infected host cell) |
|
|
How does the bird flu virus hop into humans?
|
1)occasionally a mutant bird flu virus may be transmitted to a human host.
2)Close proximity of animals and humans. |
|
|
Why should we in the US care?
|
1)Bird migratory routes-shared
2)Bird feces may carry the virus |
|
|
What are the treatments for bird flu?
|
1)Drugs to block release of virus from host cytoplasmic membrane.
-"trapped viruses"->cannot infect other cells and the spread of virus within the host is slowed. |
