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28 Cards in this Set

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What is the bird flu?
1)infuenza virus
2)Enveloped, negative strand RNA
3)Classification within groups based on two proteins in the envelope.
What are the two proteins used for classification within groups?
Hemaglutinin
Neuraminidase
What is anitgenic drift?
Small genomes changes and resulting host defense resistance. Changes in the H or N gene that are suitably small not to result in host changes.
What is antigenic shift?
large genome changes and resulting in host change.
ex: HiNi-->HsNi
How does one become infected with the bird flu?
1)Aquired through respiration
2)Attachment to ciliary epithelium in respiratory tracts
-Neruraminidase degrades mucin in resp. tract(saloic Acid.
-Hemaglutinin specifically interacts with host cel membrane receptors.
What does Neuraminidase do?
degrades mucin in resp. tract.
What does Hemaglutinin do?
Interacts with host cell membrane receptors.
->inward buldgin of host membrane
->formation of endosome
->drop in pH and uncoating of virus nucleic acid
->release into cytoplasm.
What happens in the nucleus?
The negative strand is made inte mRNA by viral polymerase and mRNA is used for packaging.
What happens in the cytoplasm?
mRNA is used for
1)viral capsid proteins
2)HA
3)NA
HA and NA then go to the ??
Endoplasmic reticulum and then to the golgi and then to host cytomembrane.
What are the symptoms of the bird flu?
Fever, chills bc of death of respiratory epitheial cells.
(extensive budding from envelope; T-Cell attack on infected host cell)
How does the bird flu virus hop into humans?
1)occasionally a mutant bird flu virus may be transmitted to a human host.
2)Close proximity of animals and humans.
Why should we in the US care?
1)Bird migratory routes-shared
2)Bird feces may carry the virus
What are the treatments for bird flu?
1)Drugs to block release of virus from host cytoplasmic membrane.
-"trapped viruses"->cannot infect other cells and the spread of virus within the host is slowed.
What is the bird flu?
1)infuenza virus
2)Enveloped, negative strand RNA
3)Classification within groups based on two proteins in the envelope.
What are the two proteins used for classification within groups?
Hemaglutinin
Neuraminidase
What is anitgenic drift?
Small genomes changes and resulting host defense resistance. Changes in the H or N gene that are suitably small not to result in host changes.
What is antigenic shift?
large genome changes and resulting in host change.
ex: HiNi-->HsNi
How does one become infected with the bird flu?
1)Aquired through respiration
2)Attachment to ciliary epithelium in respiratory tracts
-Neruraminidase degrades mucin in resp. tract(saloic Acid.
-Hemaglutinin specifically interacts with host cel membrane receptors.
What does Neuraminidase do?
degrades mucin in resp. tract.
What does Hemaglutinin do?
Interacts with host cell membrane receptors.
->inward buldgin of host membrane
->formation of endosome
->drop in pH and uncoating of virus nucleic acid
->release into cytoplasm.
What happens in the nucleus?
The negative strand is made inte mRNA by viral polymerase and mRNA is used for packaging.
What happens in the cytoplasm?
mRNA is used for
1)viral capsid proteins
2)HA
3)NA
HA and NA then go to the ??
Endoplasmic reticulum and then to the golgi and then to host cytomembrane.
What are the symptoms of the bird flu?
Fever, chills bc of death of respiratory epitheial cells.
(extensive budding from envelope; T-Cell attack on infected host cell)
How does the bird flu virus hop into humans?
1)occasionally a mutant bird flu virus may be transmitted to a human host.
2)Close proximity of animals and humans.
Why should we in the US care?
1)Bird migratory routes-shared
2)Bird feces may carry the virus
What are the treatments for bird flu?
1)Drugs to block release of virus from host cytoplasmic membrane.
-"trapped viruses"->cannot infect other cells and the spread of virus within the host is slowed.