Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
34 Cards in this Set
- Front
- Back
|
What kinds of viruses belong to picornavirus?
|
Enterovirus, Rhinovirus, Aphthovirus, Cardiovirus
|
|
|
Which picornaviruses don't have envelope and primarily in GI that could lead to CNS infections?
|
Entero, Hepato (A), and Cardio viruses
|
|
|
Which picornaviruses are responsible for URI?
|
Rhino and Aphthoviruses
|
|
|
Picornavirus: Where does the translation of the RNA single gene occur?
|
In the cytoplasm
|
|
|
True/False
3' ending highly structured that it controls genome replication. |
False >>> 5'
|
|
|
T/F
Capsid is encoded from the 5' and protease and other enzymes from the 3' |
True
|
|
|
Which viruses use leader protein before P1?
|
Apthoviruses and cardioviruses
|
|
|
Picornaviruses reside mainly where? OR replicate mainly where?
|
lymphoid tissues of oropharynx and gut
replicate in oropharynx/small intestins multiplicate in tonsils, cervical nodes, Payer's patches, mesenteric lymph nodes |
|
|
eLF-4G
|
host protein shut off
2A protease and L PRO mediate the cleavage of eLF-4G |
|
|
Flaccis paralysis due to motor neuron destruction of anterior horn, but almost erradicated due to human reservior and vaccines
|
Poliovirus
|
|
|
aseptic meningitis, herpangina (sudden fever with ulcer on tonsils)
|
Group A Coxsackie viruses
A16 >> hand-foot-mouth |
|
|
Food-and-mouth disease in animals
|
Aphthoviruses
|
|
|
Only known human oncornavirinae; adult T cell leukemia or Tropical spasitc paraparesis/HTLV1 (TSP/HAM) disease
|
Human T-cell leukemia virus
|
|
|
Which viruses impose threat via reservoirs like infected insects?
|
Flavivirdae and Toagaviridae
|
|
|
Yellow fever, west nile fever, dengue fever belong to which group?
|
Flaviviruses
|
|
|
Dengue fever virus receptor interacts with what kinds of signals of hosts' cell surface?
|
DEN-2 interacts with glycosaminoglycans and heparin sulfate; also antibody-dependent enhancement (ADE)
|
|
|
Picornavirus:
2A |
Viral protease; polyprotein cleavage
|
|
|
Pico:
2B |
Enhances vesicle formation host cellls >> RNA synthesis
|
|
|
Pico:
2C |
RNA helicase
|
|
|
Pico:
3AB |
stimulates the 3D pol activity/ 3CDpro
|
|
|
Pico:
3C |
Viral protease
|
|
|
Pico:
3D |
RNA DEP RNA POLYMERASE
|
|
|
Pico:
Vpg |
provides poly(U) primer and attached at the 5' end often right next to the L PRO
|
|
|
What are some structural proteins for flaviviruses?
|
C PRO - viral RNA ribonuc complex
PrM PRO - maturation E PRO - cell surface receptors and viral entry |
|
|
What family does rubella virus belong to?
|
Togavirus
|
|
|
Does togavirus have the structural component next to 5' or 3'?
|
3'
|
|
|
Mr. T came into the clinic with this muscles tensed and SOB. He says that he's afraid of the water. Lab shows eosinophilic inclusion bodies. He confesses he was beaten by a raccoon.
|
Rabies - Rhabdovirus
External glycopro coat -RNA with RdviralRtrans |
|
|
Out of the components of Rhadbovirus, which one is the most potent/infectious?
|
Ribonucleoprotein (RNP)
|
|
|
What is the most common cause of sporadic fatal encephalitis?
|
HSV-1
focal encephalitis w/ fever, altered consciousness/behavior *** TEMPORAL LOBE |
|
|
If you were to work at the zoo and to work with monkeys, you would need to get vaccinated for fatal encephalitis >> what virus?
|
Herpes B
|
|
|
Mother gave birth to a premature baby who is severely retarded in growth and suffers from hepatosplenomegaly >> what virus?
|
Cytomegalovirus
CMV |
|
|
Progressive multifocal leukoencephalopathy
|
JC virus - polyomaviruses
|
|
|
Mild URI, nephropathy in renal transplant patients; possible hemorrhagic cystitis in bone marrow transplant pts
|
BK viruses - polyomavirus
|
|
|
Personality change, intellectual deficits, loss of motor skills, sensory loss, death within 2-12 months
|
Progressive Multifocal Leukoencephlopathy
>> should be considered for the immunocompressed |
