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11 Cards in this Set
- Front
- Back
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What are the causative agents of mononucleosis? Which is more common?
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Epstein-Barr virus (most common)
Cytomegalovirus |
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How is EBV transmitted?
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Nasopharyngeal
15-20% of people are healthy shedders of the virus. |
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What are symptoms of EBV?
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Sore throat
Malaise Headache Anorexia Myalgias Chills ... |
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What are signs of EBV?
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Lymphadenopathy
Pharyngitis Fever Splenomegaly ... |
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What is the pathogenesis of EBV infection?
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Replication in oropharynx.
In blood, targets B cells with CD21 receptor. B cells become immortal. Cells stimulated to produce non-specific antibodies (IgG, IgM, IgA, IgD, IgE, autoantibodies, heterophile) Cytotoxic T cells respond to infected B cells and kill off the cells to limit the disease. |
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What is used to test for EBV?
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Heterophile IgM antibody usually produced with EBV. Will agglutinate with animal RBCs.
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What are the features of CMV mono? How is it different from EBV?
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Similar clinical presetation.
Not community acquired, no heterophile antibody produced, virus present in the urine. |
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What is the classification of Ebola/ Marburg viruses?
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Filovirus
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How is ebola transmitted?
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Infected body fluids or blood enter skin breaks, mucous membranes, or are swallowed.
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What tests are used to diagnose ebola?
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Enzyme linked immunosorbant assay (antigen)
Virus isolation Polymerase chain reaction (RNA) |
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What are features of ebola infection?
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Destroy dendritic cells, macrophages, neutrophils and NK cells.
Within days- fever, headache, stomach pain, diarrhea, rash, vomiting. Within weeks- chest pain, shock, bleeding and death |
