Veterinary Virology Dna Viruses

Front 1

Diseases caused by Circoviridae

Back 1

Chicken Anemia Virus (CAV)
Porcine Circovirus (PCV)
Psittacine Beak and Feather Disease Virus (PBFDV)

Front 2

Diseases caused by Parvoviridae

Back 2

Canine Parvovirus 2 (CPV)
Feline Panleukopenia Virus (FPV)
Porcine Parvovirus (SMEDI)

Front 3

Name the disease caused by Porcine Circovirus

Back 3

Postweaning Multisystemic Wasting Syndrome (PMWS)

Front 4

Describe the basic pathogenesis of PCV infection:
1. Transmission 2. How it causes dz

Back 4

1. Transmission: Fecal-oral (major), verticle & respiratory (minor)
2. Virus is non-cytopathic: causes chronic inf'n->cytokine storm->wasting

Front 5

Important factors for PCV dz

Back 5

Immune stimulant triggers (endemic infection with not all pigs sick). Intenstive management key player, genetics and vaccination

Front 6

Describe the major lesions of PCV Dz

Back 6

Key: granulomatous lymphadentitis with lymphoid depletion. Every system affected: Resp, Hepatic, GIT, Renal, Cardiac, Reproductive (gilts).

Front 7

List major clinical signs of PCV Dz

Back 7

Wasting, respiratory, diarrhea, icterus, pallor

Front 8

How is PCV Dz diffinately diagnosed?

Back 8

IHC or In Situ Hybridization
NOT serology or PCR because ubiquitous in the environmnent of pig barns

Front 9

How can PCV Dz be controlled?

Back 9

Good Biosecurity: cleaning, decrease mixing, good air quality, vaccination (sows and/or pigs)

Front 10

Describe what PBFD (Psittacine Beak and Feather Dz) would look like.

Back 10

Loss and abnormal growth of feathers, abnormal beak growth
Immunosuppression
Secondary Infections (decrease immunity)

Front 11

How is PBFD Diagnosed?

Back 11

Skin/Feather Biopseys (ok)
PCR (on blood sample),(good for enviro too!)
If +, sample again 60-90 days later

Front 12

Describe Chicken Anemia Virus dz:
Transmission
Clinical Signs
Diagnosis

Back 12

Horizontal and verticle trans.
Acute immunosuppression:
*anorexia
*depression
*anemia
*wasting
Dx: serology, virus demonstration in tissue

Front 13

T or F: Parvoviruses as naked, therefore hard to decontaminated eniro.

Back 13

True

Front 14

From what virus did the Canine Parvovirus evolve?

Back 14

Feline Panleukopenia Virus and the Mink Parvo virus

Front 15

Describe the pathogenesis of Parvovirus infections

Back 15

Fecal-Oral-lymph nodes(primary replication)-viremia-spread to heart, GIT, brain, fetuses.

Front 16

What type of cells do Parvoviruses replicate in? What enzyme is required?
List important replication sites.

Back 16

Actively dividing cells (S-phase).
Need cellular DNA Polymerase
*Crypt cells of intestine
*Peyer's Patches
*Cardiac Myocytes
*Cerebellum (granular cells)

Front 17

Describe the sequelae of in utero infections with Parvovirus for dogs and cats.

Back 17

Kittens: cerebellar hypoplasia (hypermetric gate)
Puppies: myocarditis leads to fibrosis and heartfailure.

Front 18

Discuss the clinical signs of postnatal infections with parvovirus.

Back 18

Depression
Bloody diarrhea,vomiting (dehydration and shock)
fever
leukopenia, neutropenia
Secondary Bacterial infection

Front 19

How is parvovirus diagnosed?

Back 19

Capture ELISA (less sensitive, but ok for practice)
EM
Virus Isolation
Hemagglutination

Front 20

How can parvovirus be controlled?

Back 20

Disinfection
Vaccination: must overcome maternal AB (biweekly or 'hot' vaccines)

Front 21

Describe what effect Procine Parvo has on the herd

Back 21

Reproductive Problems!
SMEDI
Stillbirth
Mummification
Embryonic Death
Infertility