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12 Cards in this Set
- Front
- Back
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DRUG REGIMEN
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*ROUTE
*DOSAGE *FREQUENCY *DURATION |
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ROUTES OF DRUG ADMINISTRATION
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*PARENTERAL (AROUND THE DIGESTIVE TRACT)
IV, IM, SQ AND INHALATION *ORAL *TOPICAL *RECTAL |
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DOSAGE
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QUANTITY OF DRUG TO BE GIVEN AT ONCE (ONE DOSE) OR AT SPECIFIED INTERVALS
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LOADING DOSE VS MAINTENANCE DOSE
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LOADING DOSE - RAISE PLASMA CONCENTRATION LEVELS TO THERAPEUTIC RANGE RAPIDLY (GIVE HIGHER 1ST DOSE AND FUTURE DOSES WILL BE LOWER TO MAINTAIN)
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STEPS OF DRUG MOVEMENT IN BODY
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*ABSORPTION
*DISTRIBUTION *BIOTRANSFORMATION/ METABOLISM *EXCRETION/ELIMINATION |
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ABSORPTION
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THE RATE AND EXTENT TO WHICH A DRUG LEAVES IT'S SITE OF ADMINISTRATION
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FACTORS AFFECTING ABSORPTION
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*ROUTE OF ADMINISTRATION
*LIPID SOLUBILITY *PH = (ACIDITY OR ALKALINITY) OF DRUG ENVIRONMENT |
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BIOAVAILABILITY
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ACTUAL QUANTITY OF DRUG THAT ENTERS SYSTEMIC CIRCULATION
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DISTRIBUTION
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THE MOVEMENT OF DRUGS FROM SYSTEMIC CIRCULATION AND INTO TISSUES WHERE THEY EXERT THEIR EFFECT
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FACTORS AFFECTING DISTRIBUTION
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*ANATOMICAL BARRIERS - BLOOD: BRAIN BARRIER, PLACENTA, HEPATIC PORTAL SYSTEM
*BLOOD FLOW TO TISSUES - LIVER, KIDNES AND BRAIN TO VITAL ORGANS *PLASMA PROTEIN BINDING |
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ELIMINATION/EXCRETION
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REMOVAL OF DRUG FROM BODY
ROUTES: KIDNEY (RENAL), LIVER (HEPATIC), LUNGS, SWEAT, MILK, SALIVA |
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BIOTRANSFORMATION/
METABOLISM |
THE BODY'S ABILITY TO CHANGE A DRUG INTO A FORM THAT CAN BE ELIMINATED
-OCCURS MOSTLY IN THE LIVER -ALSO OCCURS IN THE KIDNEYS |
