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22 Cards in this Set

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Key histologic features of epithelioid variant of hemangioma and hemangiosarcoma?
- plump epithelioid neoplastic endothelial cells
- occasional cytoplasmic vacuolation (if large: 'signet ring')
- rarely a single erythrocyte in a vacuole
Vet Pathol 44:15-24 (2007)
Immunohistochemical staining pattern of epithelioid variant of hemangioma and hemangiosarcoma?
Von Willebrand Factor + (reduced as nuclear atypia and mitotic rate increased)
CD31 +
cytokeratin -
Vet Pathol 44:15-24 (2007)
What is different in the immunohistochemical phenotype of endothelial cells from lower vertebrates (trout, Xenopus frog) compared to mammals?
They normally coexpress keratin and vimentin.
Vet Pathol 44:15-24 (2007)
Myofasciitis in the domestic ferret: gross lesions?
- atrophy of skeletal muscle
- red and white mottling and dilatation of the esophagus
- splenomegaly
- tongue: mild atrophy, some hyperkeratosis.
Vet Pathol 44:25-338 (2007)
Myofasciitis in the domestic ferret: histologic and ultrastructural lesions?
- suppurative to pyogranulomatous inflammation in skeletal muscle and fascia of esophagus, heart, limbs, body wall, head, lumbar regions
- myeloid hyperplasia of spleen and/or bone marrow
- esophagus: inflammation was circumferential.
- suppurative inflammation also in the smooth muscle tunics and associated submucosa of small intestine, stomach and urinary bladder.
- neutrophils were well-preserved.
- E.M.: mitochondrial swelling, intracellular edema, disruption of myofibrils and Z bands.
Vet Pathol 44:25-338 (2007)
Name three differences between myofasciitis and megaesophagus (age, type of inflammation, gross lesions).
Myofasciitis: young, suppurative to pyogranulomatous inflammation, no esophageal luminal dilatation (confusing, as esophageal dilatation is described as a gross feature in some ferrets with MF in this very paper).
Megaesophagus: generally older animals, minor inflammation with different distribution and cellular contents, esophageal dilatation.
Vet Pathol 44:25-338 (2007)
Pancreatitis in cats:
1- prevalence in healthy cats?
2- does occurrence of chronic pancreatitis (CP) correlate with age?
3- is CP found more often in cats with GI disease ?
1- 45 %
2- yes
3- yes, in the left limb
Vet Pathol 44:39-49 (2007)
Chronic pancreatitis in cats:
- fibrosis
- inflammation (mild compared to fibrous response), mainly lymphocytes
- cysts, cystic dilation of acini
- atrophy
- prominent lobulation: normal looking lobules and pale basophilic lobules with less zymogen
- atypical pancreatic nodules, 2 types:
1. basophilic/vacuolated type
2. eosinophilic type
- ducts: changes were generally minimal
- islets: amyloidosis in 30% of the pancreases
- NO preneoplastic changes
Vet Pathol 44:25-338 (2007)
Acute pancreatitis in cats:
- necrosis
- neutrophilic inflammation
- edema and necrosis of mesenteric fat
Vet Pathol 44:25-338 (2007)
CNS hypomyelination in rat terrier dogs:
- associated extracerebral lesions?
- congenital goiter
- hypothyroidism
- kidney: narrow cortex; cortical tubules appeared reduced in number (glomeruli close to eachother)
Vet Pathol 44:50-56 (2007)
CNS hypomyelination in rat terrier dogs:
- CNS lesions?
- myelin deficiency, most evident in corpus callosum and to a lesser extent corona radiata, pons, pyramids, lateral funiculi of spinal cord
- paralleled by axon reduction (suggesting hypomyelination was a consequence of reduced axonal formation)
Vet Pathol 44:50-56 (2007)
CNS hypomyelination in rat terrier dogs:
- Genetic defect?
- other breed affected?
- homozygous nonsense mutation in thyroid peroxidase gene; simple autosomal recessive inheritance.
- Toy Fox Terrier
Vet Pathol 44:50-56 (2007)
Differences in symptoms and(distribution of) lesions between hypothyroidism of adult onset versus congenital hypothyroidism?
Adult onset:
- dermatologic
- neuropathic
- reproductive
- cardiovascular
Inherited congenital:
- epiphysial dysplasia
- lethargy or stupor
- failure of haircoat maturation
Vet Pathol 44:50-56 (2007)
Borna disease in horses:
- Histo retina?
- Brain: Joest-Degen inclusion bodies
- Eye: neuron-to-Müller cell ration in retina smaller in diseased animals compared to controls
Vet Pathol 44:57-63
Borna disease in horses:
- Etiology?
- Characteristics of the agent?
- Primarily affects which species?
- Borna Disease Virus
- neurotropic, nonsegmented negative-strand RNA virus; BDV is the prototype of the Bornaviridae
- primarily horses and sheep (but host range is wide)
Vet Pathol 44:57-63
Canine epitheliotropic T-cell lymphoma:
Immunohistochemical phenotype?
CD3 +
CD8 +
8 out of 14 PGP 9.5 + (mainly cytoplasmic)
Vet Pathol 44:74-79 (2007)
Canine epitheliotropic T-cell lymphoma, PGP 9.5 immunoreactivity:
- correlation with disease outcome?
- what is PGP 9.5?
- no correlation with disease outcome
- protein gene product 9.5: a ubiquitin COOH-terminal hydrolase; forms part of the ubiquitin-proteasome system; this pathway is involved in cancer-related deregulation. Was originally considered specific for neural and neuroendocrine tissues (but now found in nonneuroendocrine tumor!)
Vet Pathol 44:74-79 (2007)
Feline plasmacytic pododermatitis: PCR results on: Bartonella spp, Ehrlichia spp, Anaplasma phagocytophilum, Chlamydophila felis, Mycoplasma spp, Toxoplasma gondii, Feline Herpesvirus 1 ?
All negative.
Vet Pathol 44:80-83 (2007)
Juvenile onset renal disease in Rottweiler dogs:
- expansion of Bowman's space
- diffuse b.m. mineralization
- tubular atrophy
- interstitial fibrosis
- hypercellular glomerular tufts
- occasional glomerular crescents with synechia
Vet Pathol 44:96-100 (2007)
Juvenile onset renal disease in Rottweiler dogs:
- E.M.?
- What is the major structural component of the glomerular basement membrane?
- glomerular b.m. of variable thickness, with extensive splitting or lamellation of the lamina densa.
- type IV collagen
Vet Pathol 44:96-100 (2007)
- etiology?
- vector?
- hosts?
- which cells are infected and how?
- Anaplasma marginale
- arthropod (ixodid ticks)
- cattle and other ruminants
- enters red blood cells by endocytosis after which is divides by binary fission. This study: also ENDOTHELIAL CELLS!
Vet Pathol 44:116-118 (2007)
Chronic Wasting Disease can be transmitted by which of the following fluids/excreta?
- saliva
- blood
- urine
- feces
saliva and blood. NOT by urine and feces.
Science 314(5796):133-136, 2006 (Vet Pathol 44:127 2007 "Noteworthy")