Veterinary Pathology Journal

Front 1

Key histologic features of epithelioid variant of hemangioma and hemangiosarcoma?

Back 1

- plump epithelioid neoplastic endothelial cells
- occasional cytoplasmic vacuolation (if large: 'signet ring')
- rarely a single erythrocyte in a vacuole

Hint 1

Vet Pathol 44:15-24 (2007)

Front 2

Immunohistochemical staining pattern of epithelioid variant of hemangioma and hemangiosarcoma?

Back 2

Von Willebrand Factor + (reduced as nuclear atypia and mitotic rate increased)
CD31 +
cytokeratin -

Hint 2

Vet Pathol 44:15-24 (2007)

Front 3

What is different in the immunohistochemical phenotype of endothelial cells from lower vertebrates (trout, Xenopus frog) compared to mammals?

Back 3

They normally coexpress keratin and vimentin.

Hint 3

Vet Pathol 44:15-24 (2007)

Front 4

Myofasciitis in the domestic ferret: gross lesions?

Back 4

- atrophy of skeletal muscle
- red and white mottling and dilatation of the esophagus
- splenomegaly
- tongue: mild atrophy, some hyperkeratosis.

Hint 4

Vet Pathol 44:25-338 (2007)

Front 5

Myofasciitis in the domestic ferret: histologic and ultrastructural lesions?

Back 5

- suppurative to pyogranulomatous inflammation in skeletal muscle and fascia of esophagus, heart, limbs, body wall, head, lumbar regions
- myeloid hyperplasia of spleen and/or bone marrow
- esophagus: inflammation was circumferential.
- suppurative inflammation also in the smooth muscle tunics and associated submucosa of small intestine, stomach and urinary bladder.
- neutrophils were well-preserved.
- E.M.: mitochondrial swelling, intracellular edema, disruption of myofibrils and Z bands.

Hint 5

Vet Pathol 44:25-338 (2007)

Front 6

Name three differences between myofasciitis and megaesophagus (age, type of inflammation, gross lesions).

Back 6

Myofasciitis: young, suppurative to pyogranulomatous inflammation, no esophageal luminal dilatation (confusing, as esophageal dilatation is described as a gross feature in some ferrets with MF in this very paper).
Megaesophagus: generally older animals, minor inflammation with different distribution and cellular contents, esophageal dilatation.

Hint 6

Vet Pathol 44:25-338 (2007)

Front 7

Pancreatitis in cats:
1- prevalence in healthy cats?
2- does occurrence of chronic pancreatitis (CP) correlate with age?
3- is CP found more often in cats with GI disease ?

Back 7

1- 45 %
2- yes
3- yes, in the left limb

Hint 7

Vet Pathol 44:39-49 (2007)

Front 8

Chronic pancreatitis in cats:
Histo?

Back 8

- fibrosis
- inflammation (mild compared to fibrous response), mainly lymphocytes
- cysts, cystic dilation of acini
- atrophy
- prominent lobulation: normal looking lobules and pale basophilic lobules with less zymogen
- atypical pancreatic nodules, 2 types:
1. basophilic/vacuolated type
2. eosinophilic type
- ducts: changes were generally minimal
- islets: amyloidosis in 30% of the pancreases
- NO preneoplastic changes

Hint 8

Vet Pathol 44:25-338 (2007)

Front 9

Acute pancreatitis in cats:
Histo?

Back 9

- necrosis
- neutrophilic inflammation
- edema and necrosis of mesenteric fat

Hint 9

Vet Pathol 44:25-338 (2007)

Front 10

CNS hypomyelination in rat terrier dogs:
- associated extracerebral lesions?

Back 10

- congenital goiter
- hypothyroidism
- kidney: narrow cortex; cortical tubules appeared reduced in number (glomeruli close to eachother)

Hint 10

Vet Pathol 44:50-56 (2007)

Front 11

CNS hypomyelination in rat terrier dogs:
- CNS lesions?

Back 11

- myelin deficiency, most evident in corpus callosum and to a lesser extent corona radiata, pons, pyramids, lateral funiculi of spinal cord
- paralleled by axon reduction (suggesting hypomyelination was a consequence of reduced axonal formation)

Hint 11

Vet Pathol 44:50-56 (2007)

Front 12

CNS hypomyelination in rat terrier dogs:
- Genetic defect?
- other breed affected?

Back 12

- homozygous nonsense mutation in thyroid peroxidase gene; simple autosomal recessive inheritance.
- Toy Fox Terrier

Hint 12

Vet Pathol 44:50-56 (2007)

Front 13

Differences in symptoms and(distribution of) lesions between hypothyroidism of adult onset versus congenital hypothyroidism?

Back 13

Adult onset:
- dermatologic
- neuropathic
- reproductive
- cardiovascular
Inherited congenital:
- epiphysial dysplasia
- lethargy or stupor
- failure of haircoat maturation

Hint 13

Vet Pathol 44:50-56 (2007)

Front 14

Borna disease in horses:
- Histo retina?

Back 14

- Brain: Joest-Degen inclusion bodies
- Eye: neuron-to-Müller cell ration in retina smaller in diseased animals compared to controls

Hint 14

Vet Pathol 44:57-63

Front 15

Borna disease in horses:
- Etiology?
- Characteristics of the agent?
- Primarily affects which species?

Back 15

- Borna Disease Virus
- neurotropic, nonsegmented negative-strand RNA virus; BDV is the prototype of the Bornaviridae
- primarily horses and sheep (but host range is wide)

Hint 15

Vet Pathol 44:57-63

Front 16

Canine epitheliotropic T-cell lymphoma:
Immunohistochemical phenotype?

Back 16

CD3 +
CD8 +
8 out of 14 PGP 9.5 + (mainly cytoplasmic)

Hint 16

Vet Pathol 44:74-79 (2007)

Front 17

Canine epitheliotropic T-cell lymphoma, PGP 9.5 immunoreactivity:
- correlation with disease outcome?
- what is PGP 9.5?

Back 17

- no correlation with disease outcome
- protein gene product 9.5: a ubiquitin COOH-terminal hydrolase; forms part of the ubiquitin-proteasome system; this pathway is involved in cancer-related deregulation. Was originally considered specific for neural and neuroendocrine tissues (but now found in nonneuroendocrine tumor!)

Hint 17

Vet Pathol 44:74-79 (2007)

Front 18

Feline plasmacytic pododermatitis: PCR results on: Bartonella spp, Ehrlichia spp, Anaplasma phagocytophilum, Chlamydophila felis, Mycoplasma spp, Toxoplasma gondii, Feline Herpesvirus 1 ?

Back 18

All negative.

Hint 18

Vet Pathol 44:80-83 (2007)

Front 19

Juvenile onset renal disease in Rottweiler dogs:
Histo?

Back 19

- expansion of Bowman's space
- diffuse b.m. mineralization
- tubular atrophy
- interstitial fibrosis
- hypercellular glomerular tufts
- occasional glomerular crescents with synechia

Hint 19

Vet Pathol 44:96-100 (2007)

Front 20

Juvenile onset renal disease in Rottweiler dogs:
- E.M.?
- What is the major structural component of the glomerular basement membrane?

Back 20

- glomerular b.m. of variable thickness, with extensive splitting or lamellation of the lamina densa.
- type IV collagen

Hint 20

Vet Pathol 44:96-100 (2007)

Front 21

Anaplasmosis:
- etiology?
- vector?
- hosts?
- which cells are infected and how?

Back 21

- Anaplasma marginale
- arthropod (ixodid ticks)
- cattle and other ruminants
- enters red blood cells by endocytosis after which is divides by binary fission. This study: also ENDOTHELIAL CELLS!

Hint 21

Vet Pathol 44:116-118 (2007)

Front 22

Chronic Wasting Disease can be transmitted by which of the following fluids/excreta?
- saliva
- blood
- urine
- feces

Back 22

saliva and blood. NOT by urine and feces.

Hint 22

Science 314(5796):133-136, 2006 (Vet Pathol 44:127 2007 "Noteworthy")