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7 Cards in this Set
- Front
- Back
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what are the solubilites of the different vasodilators
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Hydralazine is water soluble
Minoxidil is insoluble Sodium Nitroprusside is water soluble |
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What is the metabolism for Hydralazine
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N-acetylation with cyclization than hydroxylation, N-formylation with cyclization
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what is the other form of metabolism for Hydralazine?
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Oxidative loss of hydrazinyl group to 1-hydroxyl
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What is necessary for Minoxidil activity?
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N-Oxide, inhibit camp phosphodiesterase
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what is necessary for activity of Sodium Nitroprusside?
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NO group
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How is Sodium Nitroprusside rapidly converted and metabolized in the liver?
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-CN+R-SH to CN-S-H (Thiocyanate)
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What is unstable in solution to light and why?
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Sodium Nitroprusside b/c of FE+3 to FE+2
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