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12 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Large Vessel Vasculitides
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Giant cell temporal arteritis
Takayasu arteritis |
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Medium vessel vasculitides
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Polyarteritis nodosa
Kawasaki disease |
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Small vessel vasculitides
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Wegeners granulomatosis
churg-strauss syn microscopic polyangiitis |
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giant cell temporal arteritis
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MC, chronic
affects head vessels- temporal, opthalmic--blindness, vertebral, AORTA- giant cell aortitis t-cell mediated MHC II - granuloma NODULAR INTIMAL THICKENING GRANULOMA ON INTERNAL ELASTIC LAMINA WITH MØ AND T CELLS ENDS IN SCAR FEVER, PAIN, FATIGUE, DIPLOPIA GIVE CORTICOSTEROIDS |
granulomatos inflammation
affects the temporal artery causes polymyalgia rheumatica affects the over 50 |
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takayasu arteritis
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granulomatous
affects the below 50 |
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polyarteritis nodosa
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necrotizing inflam
involves the renal artery but not the pulmonary vessels |
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kawasaki disease
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arteritis with mucocutaneous lymph node syndrome
in kids coronary arteries can be involved in aneurysm formation or thrombosis anti endothelial cell antibodies can predispose to kawasaki |
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wegeners granulomatosis
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granulomatous inflame effects the respiratory system vessels
AND necrotizing to small vessels involves c-ANCAs assoc with asthma and blood eosinophilia |
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churg strauss
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eosinophil rich and granulomatous effecting resp. system
necrotizing effecting small vessels p-ANCAs |
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microscopic polyangiitis
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necrotizing on small vessels
no immune complex deposition can cause necrotising glomerulonephritis and pulmonary capillaries |
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cytoplasmic anti neutrophil cytoplasmic antibody
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target proteinase-3
in neutrophil granules activates the neutrophils to continue inflammation- ROS and proteolytic enzymes |
both show the degree of inflammatory activity
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perinuclear anti neutrophil cytoplasmic antibody
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targets the myeloperoxidase
activates the neutrophils to continue inflammation- ROS and proteolytic enzymes |
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