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65 Cards in this Set
- Front
- Back
What is atherosclerosis?
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A diffuse disease process in arteries; artheromas containing cholesterol and lipid form within the intima and inner media, often accompanied by ulcerations and smooth muscle hyperplasia
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What is the common theory of how atherosclerosis is initiated?
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Endothelial injury --> platelets adhere --> growth factors released --> smooth muscle hyperplasia/plaque deposition
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What are the risk factors for atherosclerosis?
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HTN, smoking, diabetes mellitus, family history, hypercholesterolemia, high LDL, obesity, and sedentary lifestyle
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What are the common sites of plaque formation in arteries?
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Branch points (carotid bifurcation), tethered sites (superficial femoral artery [SFA] in Hunter's canal in the leg)
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What must be present for a successful arterial bypass operation?
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1. Inflow (e.g. patent aorta)
2. Outflow (e.g. open distal popliteal artery) 3. Run off (e.g. patent trifurcation vessels down to the foot) |
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What is the major principle of safe vascular surgery?
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Get proximal and distal control of the vessel to be worked on
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What does it mean to "POTTS" a vessel?
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Place a vessel loop twice around a vessel so that if you put tension on the vessel loop, it will occlude the vessel
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What is the suture needle orientation through graft versus diseased artery in a graft to artery anastomosis?
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Needle "in to out" of the lumen in diseased artery to help tack down the plaque and the needle "out-to-in" on the graft
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What are the layers of an artery?
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1. Intima
2. Media 3. Adventitia |
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Which arteries supply the blood vessel itself?
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Vasovasorum
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What is a true aneurysm?
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Dilation (> 2X nL diameter) of all three layers of a vessel
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What is a false (pseudo) aneurysm?
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Dilation of artery not involving all three layers (e.g. hematoma with fibrous covering)
Often connects with vessel lumen and blood swirls inside to the false aneurysm |
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What is "ENDOVASCULAR" repair?
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Placement of a catheter in artery and then deployment of a graft intraluminally
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How can you remember the orientation of the lower exterior arteries below the knee on A-gram?
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"L.A.M.P"
Lateral Anterior tibial Medial Posterior tibial |
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What is peripheral vascular disease (PVD)?
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Occlusive atherosclerotic disease in the lower extremities
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What is the most common site of arterial atherosclerotic occlusion in the lower extremities?
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Occlusion of the SFA in Hunter's canal
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What are the symptoms of PVD?
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Intermittent claudication, rest pain, erectile dysfunction, sensorimotor impairment, tissue loss
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What is Intermittent claudication?
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Pain, cramping, or both of the lower extremity, usually the calf muscle, after walking a specific distance, then the pain/cramping resolves after stopping for a specific amount of time while standing; this pattern is reproducible
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What is rest pain?
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Pain the foot, usually over the distal metatarsals; this pain arises at rest (classically at night, awakening the patient)
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What classically resolves rest pain?
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Hanging the foot over the side of the bed or standing; gravity affords some extra-flow to the ischemic area
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How can vascular causes of claudication be differentiated from nonvascular causes, such as neurogenic claudication or arthritis?
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History (in the vast majority of pts) and noninvasive tests; remember vascular claudication appears after a specific distance and resolves after a specific time of rest while standing (not so with most other forms of claudication)
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What is the DDx of lower extremity claudication?
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Neurogenic (e.g. nerve entrapment/discs)
Arthritis Coarctation of the aorta Popliteal artery syndrome Chronic compartment syndrome Neuromas Anemia Diabetic neuropathy pain |
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What are the signs of PVD?
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Absent pulse, bruits, muscular atrophy, decreased hair growth, thick toenails, tissue necrosis/ulcers/infection
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What is the site of a PVD ulcer vs. a venous stasis ulcer?
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PVD arterial insufficiency uler - usually on the toes/foot
Venous stasis ulcer - medial malleolus (ankle) |
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What is the ABI?
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The Ankle to Brachial Index (ABI): simply the ratio of the systolic blood pressure at the ankle to the systolic blood pressure at the arm (brachial artery) A:B; ankle pressure taken with Doppler; the ABI is noninvasive
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What ABIs are associated with normals, claudicators, and rest pain?
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Normal ABI = >1.0
Claudicator ABI = <0.6 Rest pain ABI = <0.4 |
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Who gets false ABI readings?
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Pts with calcified arteries, especially those with diabetes
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What are PVRs?
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Pulse Volume Recodings; pulse wave forms are recorded from lower extremities representing volume of blood per heart beat at sequential sites down leg
A large wave form means good collateral blood flow (noninvasive using pressure cuffs) |
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Prior to surgery for chronic PVD, what diagnostic test will every patient receive?
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A-gram (arteriogram: dye in vessel and x-rays) maps disease and allows for best treatment option (i.e. angioplasty vs. surgical bypass vs. endarterectomy)
Gold standard for diagnosing PVD |
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What is the bedside management of a patient with PVD?
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1. Sheep skin (easy on heels)
2. Foot cradle (keeps sheets/blankets off the feet) 3. Skin lotion to avoid further cracks in the skin that can go on to form a fissure and then an ulcer |
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What are the indications for surgical treatment in PVD?
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"S.T.I.R"
- Severe claudication refractory to conservative treatment that affects quality of life/livelihood (e.g. can't work b/c of the claudication) - Tissue necrosis - Infection - Rest pain |
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What is the treatment of claudication?
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For the vast majority, conservative treatment, including exercise, smoking cessation, treatment of HTN, diet, aspirin, with or without Trental (pentoxifylline)
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How can you remember the medical conservative treatment for claudication?
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P.A.C.E
- Pentoxifylline - Aspirin - Cessation of smoking - Exercise |
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How does aspirin work?
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Inhibits platelets (inhibits cyclooxygenase and platelet aggregation)
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How does Trental (pentoxifylline) work?
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Results in increased RBC deformity and flexibility
think: pentoXifylline = RBC fleXibility |
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What is the risk of limb loss with claudication?
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Five percent limb loss at 5 years (think: 5 in 5), 10% at 10 years (think: 10 in 10)
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What is the risk of limb loss with rest pain?
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More than 50% of pts will have amputation of the limb at some point
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In the pt with PVD, what is the main postoperative concern?
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Cardiac status, b/c most pts with PVD have coronary artery disease; about 20% have an AAA
MI is the most common cause of postoperative death after a PVD operation |
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What is Leriche's syndrome?
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Impotence, buttock claudication, and leg muscle atrophy from occlusive disease of the iliacs/distal aorta
Think: "C.I.A." - Claudication - Impotence - Atrophy (think: CIA spy Leriche) |
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What are the treatment options for severe PVD?
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1. Surgical graft bypass
2. Angioplasty - balloon dilation 3. Endarterectomy - remove diseased intima and media 4. Surgical patch angioplasty (place patch over stenosis) |
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What is a FEM-POP bypass?
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Bypass SFA occlusion with a graft from the femoral artery to the popliteal artery
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What is a FEM-DISTAL bypass?
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Bypass from the femoral artery to a distal artery (peroneal artery, anterior tibilal artery, or posterior tibilal artery)
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What graft material has the longest patency rate?
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Autologous vein graft
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What is an "in situ" vein graft?
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Saphrenous vein is more less left in place, all branches are ligated, and the vein valves are broken with a small hook or cut out. A vein can also be used if reversed so that the valves do not cause a problem
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What type of graft is used for above-the-knee FEM-POP bypass?
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Either vein or Gortex graft; vein still has better patency
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What type of graft is used for below-the-knee FEM-POP or FEM-DISTAL bypass?
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Must use vein graft; prostethic grafts have a prohibitive thrombosis rate
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What is DRY gangrene?
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Dry necrosis of tissue without signs of infection ("mummified tissue")
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What is WET gangrene?
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Moist necrotic tissue with signs of infection
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What is blue toe syndrome?
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Intermittent painful blue toes (or fingers) due to microemboli from a proximal arterial plaque
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What are the indications for lower extremity amputations?
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Irreversible tissue ischemia (no hope for revascularization bypass) and necrotic tissue, severe infection, severe pain with no bypassable vessels, or if pt is not interested in a bypass procedure
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What is a Ray amputation?
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Removal of toe and head of metatarsal
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What is acute arterial occlusion?
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Acute occlusion of an artery, usually by embolization; other causes include acute thrombosis of an atheromatous lesion, vascular trauma
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What are the classic signs/symptoms of acute arterial occlusion?
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The "six P's"
- Pain - Paralysis - Pallor - Parasthesia - Polor (Poikilothermia) - Pulselessness |
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What is the classic timing of pain with acute arterial occlusion from an embolus?
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Acute onset; the patient can classically tell you when and where it happened
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What is the immediate preoperative management of acute arterial occlusion?
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1. Anticoagulate with IV heparin (bolus followed by constant infusion)
2. A-gram |
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What are the sources of emboli in acute arterial occlusion?
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1. Heart - 85% (e.g. clot from AFib, clot forming on dead muscle after MI, endocarditis, myxoma)
2. Aneurysms 3. Atheromatous plaque (atheroembolism) |
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What is the most common cause of embolus from the heart in acute arterial occlusion?
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AFib
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What is the most common site of arterial occlusion by an embolus?
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Common femoral artery (SFA is the most common site of arterial occlusion from atherosclerosis)
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What diagnostic studies are in order for acute arterial occlusion?
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1. A-gram
2. ECG (looking for MI, AFib) 3. Echocardiogram (+/-) looking for clot, MI, valve vegetation |
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What is the treatment of acute arterial occlusion?
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Surgical embolectomy via cutdown and Fogarty balloon (bypass is reserved for embolectomy failure)
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What is a Fogarty?
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Fogarty balloon catheter - catheter with a balloon tip that can be inflated with saline; used for embolectomy
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How do you use a Fogarty catheter?
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Insinuate the catheter with the balloon deflated past the embolus and then inflate the balloon and pull the catheter out; the balloon brings the embolus with it
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How many mm in diameter is a 12 French Fogarty catheter?
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Simple; to get mm from French measurements, divide the French number by pi, or 3.14; thus, a 12 French catheter is 12/3 = 4 mm in diameter
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What must you look for postoperatively after reperfusion of a limb?
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Compartment syndrome, hyperkalemia, renal failure from myoglobinuria, MI
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What is compartment syndrome?
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The leg (calf) is separated into compartments by very unyielding fascia; tissue swelling from reperfusion can increase the intracompartmental pressure, resulting in decreased capillary flow, ischemia, and myonecrosis; myonecrosis may occur after the intracompartment pressure reaches only 30 mmHg
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