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65 Cards in this Set

  • Front
  • Back
What is atherosclerosis?
A diffuse disease process in arteries; artheromas containing cholesterol and lipid form within the intima and inner media, often accompanied by ulcerations and smooth muscle hyperplasia
What is the common theory of how atherosclerosis is initiated?
Endothelial injury --> platelets adhere --> growth factors released --> smooth muscle hyperplasia/plaque deposition
What are the risk factors for atherosclerosis?
HTN, smoking, diabetes mellitus, family history, hypercholesterolemia, high LDL, obesity, and sedentary lifestyle
What are the common sites of plaque formation in arteries?
Branch points (carotid bifurcation), tethered sites (superficial femoral artery [SFA] in Hunter's canal in the leg)
What must be present for a successful arterial bypass operation?
1. Inflow (e.g. patent aorta)
2. Outflow (e.g. open distal popliteal artery)
3. Run off (e.g. patent trifurcation vessels down to the foot)
What is the major principle of safe vascular surgery?
Get proximal and distal control of the vessel to be worked on
What does it mean to "POTTS" a vessel?
Place a vessel loop twice around a vessel so that if you put tension on the vessel loop, it will occlude the vessel
What is the suture needle orientation through graft versus diseased artery in a graft to artery anastomosis?
Needle "in to out" of the lumen in diseased artery to help tack down the plaque and the needle "out-to-in" on the graft
What are the layers of an artery?
1. Intima
2. Media
3. Adventitia
Which arteries supply the blood vessel itself?
Vasovasorum
What is a true aneurysm?
Dilation (> 2X nL diameter) of all three layers of a vessel
What is a false (pseudo) aneurysm?
Dilation of artery not involving all three layers (e.g. hematoma with fibrous covering)
Often connects with vessel lumen and blood swirls inside to the false aneurysm
What is "ENDOVASCULAR" repair?
Placement of a catheter in artery and then deployment of a graft intraluminally
How can you remember the orientation of the lower exterior arteries below the knee on A-gram?
"L.A.M.P"
Lateral Anterior tibial
Medial Posterior tibial
What is peripheral vascular disease (PVD)?
Occlusive atherosclerotic disease in the lower extremities
What is the most common site of arterial atherosclerotic occlusion in the lower extremities?
Occlusion of the SFA in Hunter's canal
What are the symptoms of PVD?
Intermittent claudication, rest pain, erectile dysfunction, sensorimotor impairment, tissue loss
What is Intermittent claudication?
Pain, cramping, or both of the lower extremity, usually the calf muscle, after walking a specific distance, then the pain/cramping resolves after stopping for a specific amount of time while standing; this pattern is reproducible
What is rest pain?
Pain the foot, usually over the distal metatarsals; this pain arises at rest (classically at night, awakening the patient)
What classically resolves rest pain?
Hanging the foot over the side of the bed or standing; gravity affords some extra-flow to the ischemic area
How can vascular causes of claudication be differentiated from nonvascular causes, such as neurogenic claudication or arthritis?
History (in the vast majority of pts) and noninvasive tests; remember vascular claudication appears after a specific distance and resolves after a specific time of rest while standing (not so with most other forms of claudication)
What is the DDx of lower extremity claudication?
Neurogenic (e.g. nerve entrapment/discs)
Arthritis
Coarctation of the aorta
Popliteal artery syndrome
Chronic compartment syndrome
Neuromas
Anemia
Diabetic neuropathy pain
What are the signs of PVD?
Absent pulse, bruits, muscular atrophy, decreased hair growth, thick toenails, tissue necrosis/ulcers/infection
What is the site of a PVD ulcer vs. a venous stasis ulcer?
PVD arterial insufficiency uler - usually on the toes/foot
Venous stasis ulcer - medial malleolus (ankle)
What is the ABI?
The Ankle to Brachial Index (ABI): simply the ratio of the systolic blood pressure at the ankle to the systolic blood pressure at the arm (brachial artery) A:B; ankle pressure taken with Doppler; the ABI is noninvasive
What ABIs are associated with normals, claudicators, and rest pain?
Normal ABI = >1.0
Claudicator ABI = <0.6
Rest pain ABI = <0.4
Who gets false ABI readings?
Pts with calcified arteries, especially those with diabetes
What are PVRs?
Pulse Volume Recodings; pulse wave forms are recorded from lower extremities representing volume of blood per heart beat at sequential sites down leg
A large wave form means good collateral blood flow
(noninvasive using pressure cuffs)
Prior to surgery for chronic PVD, what diagnostic test will every patient receive?
A-gram (arteriogram: dye in vessel and x-rays) maps disease and allows for best treatment option (i.e. angioplasty vs. surgical bypass vs. endarterectomy)
Gold standard for diagnosing PVD
What is the bedside management of a patient with PVD?
1. Sheep skin (easy on heels)
2. Foot cradle (keeps sheets/blankets off the feet)
3. Skin lotion to avoid further cracks in the skin that can go on to form a fissure and then an ulcer
What are the indications for surgical treatment in PVD?
"S.T.I.R"
- Severe claudication refractory to conservative treatment that affects quality of life/livelihood (e.g. can't work b/c of the claudication)
- Tissue necrosis
- Infection
- Rest pain
What is the treatment of claudication?
For the vast majority, conservative treatment, including exercise, smoking cessation, treatment of HTN, diet, aspirin, with or without Trental (pentoxifylline)
How can you remember the medical conservative treatment for claudication?
P.A.C.E
- Pentoxifylline
- Aspirin
- Cessation of smoking
- Exercise
How does aspirin work?
Inhibits platelets (inhibits cyclooxygenase and platelet aggregation)
How does Trental (pentoxifylline) work?
Results in increased RBC deformity and flexibility

think: pentoXifylline = RBC fleXibility
What is the risk of limb loss with claudication?
Five percent limb loss at 5 years (think: 5 in 5), 10% at 10 years (think: 10 in 10)
What is the risk of limb loss with rest pain?
More than 50% of pts will have amputation of the limb at some point
In the pt with PVD, what is the main postoperative concern?
Cardiac status, b/c most pts with PVD have coronary artery disease; about 20% have an AAA
MI is the most common cause of postoperative death after a PVD operation
What is Leriche's syndrome?
Impotence, buttock claudication, and leg muscle atrophy from occlusive disease of the iliacs/distal aorta
Think: "C.I.A."
- Claudication
- Impotence
- Atrophy
(think: CIA spy Leriche)
What are the treatment options for severe PVD?
1. Surgical graft bypass
2. Angioplasty - balloon dilation
3. Endarterectomy - remove diseased intima and media
4. Surgical patch angioplasty (place patch over stenosis)
What is a FEM-POP bypass?
Bypass SFA occlusion with a graft from the femoral artery to the popliteal artery
What is a FEM-DISTAL bypass?
Bypass from the femoral artery to a distal artery (peroneal artery, anterior tibilal artery, or posterior tibilal artery)
What graft material has the longest patency rate?
Autologous vein graft
What is an "in situ" vein graft?
Saphrenous vein is more less left in place, all branches are ligated, and the vein valves are broken with a small hook or cut out. A vein can also be used if reversed so that the valves do not cause a problem
What type of graft is used for above-the-knee FEM-POP bypass?
Either vein or Gortex graft; vein still has better patency
What type of graft is used for below-the-knee FEM-POP or FEM-DISTAL bypass?
Must use vein graft; prostethic grafts have a prohibitive thrombosis rate
What is DRY gangrene?
Dry necrosis of tissue without signs of infection ("mummified tissue")
What is WET gangrene?
Moist necrotic tissue with signs of infection
What is blue toe syndrome?
Intermittent painful blue toes (or fingers) due to microemboli from a proximal arterial plaque
What are the indications for lower extremity amputations?
Irreversible tissue ischemia (no hope for revascularization bypass) and necrotic tissue, severe infection, severe pain with no bypassable vessels, or if pt is not interested in a bypass procedure
What is a Ray amputation?
Removal of toe and head of metatarsal
What is acute arterial occlusion?
Acute occlusion of an artery, usually by embolization; other causes include acute thrombosis of an atheromatous lesion, vascular trauma
What are the classic signs/symptoms of acute arterial occlusion?
The "six P's"
- Pain
- Paralysis
- Pallor
- Parasthesia
- Polor (Poikilothermia)
- Pulselessness
What is the classic timing of pain with acute arterial occlusion from an embolus?
Acute onset; the patient can classically tell you when and where it happened
What is the immediate preoperative management of acute arterial occlusion?
1. Anticoagulate with IV heparin (bolus followed by constant infusion)
2. A-gram
What are the sources of emboli in acute arterial occlusion?
1. Heart - 85% (e.g. clot from AFib, clot forming on dead muscle after MI, endocarditis, myxoma)
2. Aneurysms
3. Atheromatous plaque (atheroembolism)
What is the most common cause of embolus from the heart in acute arterial occlusion?
AFib
What is the most common site of arterial occlusion by an embolus?
Common femoral artery (SFA is the most common site of arterial occlusion from atherosclerosis)
What diagnostic studies are in order for acute arterial occlusion?
1. A-gram
2. ECG (looking for MI, AFib)
3. Echocardiogram (+/-) looking for clot, MI, valve vegetation
What is the treatment of acute arterial occlusion?
Surgical embolectomy via cutdown and Fogarty balloon (bypass is reserved for embolectomy failure)
What is a Fogarty?
Fogarty balloon catheter - catheter with a balloon tip that can be inflated with saline; used for embolectomy
How do you use a Fogarty catheter?
Insinuate the catheter with the balloon deflated past the embolus and then inflate the balloon and pull the catheter out; the balloon brings the embolus with it
How many mm in diameter is a 12 French Fogarty catheter?
Simple; to get mm from French measurements, divide the French number by pi, or 3.14; thus, a 12 French catheter is 12/3 = 4 mm in diameter
What must you look for postoperatively after reperfusion of a limb?
Compartment syndrome, hyperkalemia, renal failure from myoglobinuria, MI
What is compartment syndrome?
The leg (calf) is separated into compartments by very unyielding fascia; tissue swelling from reperfusion can increase the intracompartmental pressure, resulting in decreased capillary flow, ischemia, and myonecrosis; myonecrosis may occur after the intracompartment pressure reaches only 30 mmHg