Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
15 Cards in this Set
- Front
- Back
|
What species is vancomycin used against?
|
MRSA & enterococcal infections
|
|
|
What mechanism does vancomycin use? How does resistance develop?
|
prevents elongation of peptidoglycan and cross linking
resistance develops if d-ala binding site modified |
|
|
Coverage of vancomycin
|
gram + only
useful against methicillin & penicillin resistant s. aureus, and for people with penicillin allergies |
|
|
how is vancomycin administered?
|
IV for systemic infections or orally for GI infections caused by staph or c. diff
|
|
|
What are side effects of vancomycin?
|
ototoxic
nephrotoxic red man |
|
|
What mechanism does fosfomycin use?
|
inhibits NAG to NAM reduction
|
|
|
coverage of fosfomycin
|
gram +
gram - |
|
|
How is fosfomycin administered & excreted?
|
orally
kidney excretion |
|
|
What is a clinical use for fosfomycin?
|
megadose for uncomplicated UTIs
|
|
|
What mechanism does bacitracin use?
|
inhibits cell wall synthesis by interfering with final dephosphorylation step
|
|
|
bacitracin coverage
|
gram + bacteria
can be combined with neomycin & polymyxin which have gram - activity |
|
|
How is bacitracin excreted?
|
kidney
|
|
|
What mechanism does cycloserine use?
|
inhibits cell wall synthesis by inhibiting attachment of peptide chain to peptidoglycan unit
*bactericidal or bacteriostatic |
|
|
What is the clinical use for cycloserine?
|
2nd line, broad spectrum treatment of extrapulmonary TB & UTIs
|
|
|
What side effects are associated with cycloserine?
|
serious CNS
|
