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17 Cards in this Set

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Vancomycin mechanism
Inhibition of bacterial cell wall cross-linking by binding to D-ala-D-ala

Bacteriocidal
Intermediate resistance to vancomycin
Overproduction of PBP2, PBP2a

Overproduction of peptidoglycan precursors: thicker cell walls; drugs can't get to site of wall synthesis
High level resistance to vancomycin transfer means
Transposon encoded from enterococcus
High level resistance to vancomycin mechanism
5 proteins essential:
-Removing terminal D-ala
-Attaching of D-lac

Results in D-ala-D-lac which can't be bound by vancomycin, dancomycin
Vancomycin absorption
Not absorbed in GI tract

IV administration
Vancomycin distribution
Well distribution

CSF penetration poor unless meninges are inflamed
Vancomycin metabolism
Little metabolism.

T1/2 = 6 hr.
Vancomycin excretion
Renal (glomerular) filtration

Excreted unchanged in urine
Vancomycin therapeutic uses
Used to treat SERIOUS INFECTIONS:
- HA - MRSA
- Clostridium difficile (antibiotic induced colitis)
Vancomycin adverse effects
Hypersensitivity

High dose ototoxicity, nephrotoxicity

"Red man" syndrome; flushing in neck, upper body in first after high dose administration due to histamine release
Daptomycin mechanism of action
Penetrates membrane

Pore created that depolarizes the bacteria
Daptomycin resistance mechanism
Alteration of membrane polarity that changes membrane charge

Alteration of 3 component regulatory system involved in the response of bacteria to antimicrobials
Daptomycin absorption
IV
Daptomycin distribution
Penetrates plasma and interstitial fluid

Doesn't penetrate CSF
Daptomycin metabolism
Isn't metabolized

T1/2 = 8.1 hr.
Daptomycin clinical uses
Complicated skin, soft tissue infections

VISA, VRSA infections
Daptomycin adverse effects
GI irritation

Increases in creatine kinase (only dose 1x/day)

Contraindicated with statins; increased chance of muscle injury