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15 Cards in this Set

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what is transformation zone and why is it sampled in a pap smear
the area between the orginial squamocloumnar jnxtn and the new squamocolumnar jnxtn (which is the area between endocerv epi and extocervi squamos cells)
it is lined by metaplastic squamous epithelium, not precancerous, but it is the location where dysplasia which is precancerous often arises
what are histologic features of HPV
exophytic mass, endophytic ulcer, or inflitrative mass
cells grow beyond BM and infiltrate stroma
what is a koiolocyte
A squamous cell, often binucleated, showing a perinuclear halo; characteristic of condyloma acuminatum.
what is a condyloma
Condyloma acuminatum, a papilloma with a central core of connective tissue in a treelike structure covered with epithelium, usually occurring on the mucous membrane or skin of the external genitals or in the perianal region
what is the difference between HPV 8, 11, and 16, 18 and why do some have a greater propensity to progress to incasive carcinoma
8, 11 low risk
16, 18, 31, 33 high risk
high risk types are able to insert their genome into the host DNA and have genes that interfere with cell cycling
histologic features of low grade squamos dysplasia
level of basal squamous cell proliferation and mitotic activity stays in lower third of the squamouss cells epitthelium thickness
histologic features of high grade squamous dysplasia
level of basal cell squamous cell proliferation and mitotic activity rises to the middle or upper third of squamous cell epi thickness
risk factors for HPV and developing dysplasia
early age of first sex intercourse, numberous partners, smoking makes it harder to get rid of virus
what is lichen sclerosis and typical presentation
a common cause of white changes of the vulva
can affect any age, most ly postmenopausal
lesions can be painful
white plaques that give a parchment paper like look
micro: thin, atrophic epithlium with stromal band infiltrate
older lesions have dense fibrosis
small risk of SSC, NONHPV SSC!!!
hist presentation of herpes
nonpainful vesicles and shallow excruciatingly painful ulcerations
histo: early glasssy nuclei, then prominent nuclear inclusions.
histo: later 3M: multinucleation, margination of chromatin, molding of nuclei. also see inclusions
hist presentation of HPV
low grade dysp regress or persist, those from low grade HPV never progress
high grade may regress, persist, or progress 70% go to SSC in 1-20 yrs if untreated
hist presentation of chlamydia
infectious cervicitis
mucopurulent discharge, urethritis
histo: follicular cervicitis only semi specific must confirm by culture
complications endometritis and salpingitis, PID
what are the features of endocervical polyp,
polyp is from external os, usually asymptomatic, can ulcerate and bleed, overgrowth of benign stroma and epi
how do you distinguish endocervical polyp from adenocarcinoma of endocervix
AIS is in glandular component of cervix, in transformation zone, strong association with HPV, and characterized by loss of cyto mucin, nuclear enlargement, hyperchromatic and mitotic active nuclei
who gets paget's disease, whats its presentation and what are the hist features
older post menopausal women
red and eczematous with irregular borders, intrapeithelial proliferation of malignant glandular like cells (ie only occasional invasion of stroma)
margins not clearly circumscribed which makes it hard to excise
slowly progressive, prx depends on invasion
15% have malignancy elsewhere