Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
12 Cards in this Set
- Front
- Back
|
What are examples of uncoupling agents?
|
1) Dinitrophenol
2) ASA (if overdose) 3) thermogenin (in brown fat) |
|
|
What is the test for chronic granulomatous disease?
|
Nitroblue tetrazolium (negative)
NADPH Oxidase deficiency → no ROS's in PMN's |
|
|
What are the catalase positive organisms that are dangerous to people w/ CGD?
|
S. aureus
E. coli Aspergillus |
|
|
What are causes of achalasia?
|
1) Congenital
2) Chagas disease (Trypanosoma cruzi) if C./S. American - amastigotes release neurotoxin and destroy myenteric plexus |
|
|
What is the vector of chagas disease? The Tx?
|
Vector = Reduviid bug
Tx = Nifurtimox |
|
|
What is the chromosomal abnormality that occurs in 2 types of AML?
|
1) M2 = AML w/ maturation t(8;21)
2) M3 = t(15;17) → PML/RARα which prevents differentiation of myeloblasts - Tx = Vit A (all-trans retinoic acid) |
|
|
What lower extremity nerve is likely damaged d/t severe knee trauma? What are the deficits?
|
Tibial nerve (L4-S2)
Motor = Calcaneovalgocavus position: - dorsiflexion - eversion Sensory = Sole - plantar nerves (medial and lateral damaged) |
|
|
What is Trousseau's syndrome?
|
Migratory thrombophlebitis.
Hypercoagulability of adenocarcinoma (pancreas, colon, lung). d/t release of thromboplastin-like substnace |
|
|
What are the signs of hypoparathyroidism?
|
1) Chvostek's sign = Cheek contraction d/t tapping CNVII
2) Trousseau's sign = Tighten cuff → carpal spasm (occusion of brachial artery) |
|
|
What is Waterhouse-Friderichsen Syndrome?
|
Constellation of:
- Meningococcemia (n.meningitidis) - DIC - adrenal hemorrhage (acute 1º AI) See a petechial rash. |
|
|
What are the receptors of the SANS and what are their effects?
|
α1 = Gq (IP3)
- peripheral constriction (skin/viscera) α2 = Gi (↓cAMP) - ↓ secretion (INS, NE) ß1 = Gs (↑cAMP) - ↑ heart - ↑ fat burn - kidneys (↑renin) ß2 = Gs (↑cAMP) - ↑ heart - ↑ fat burn - lungs (bronchodilate) - uterus (relax) - ↑ secretion (INS) |
|
|
What receptors does NE work on and what is the result?
|
Both α > ß1
- α1 → vasodilation - α2 → ↓ secretion (NE/INS) - ß1 → ↑contractility (heart) |
