Uvm Pathophysiology - Cancer

Front 1

NEOPLASIA MEANS

Back 1

CELLS GROW UNREGULATED
GROW W/O SIGNAL THAT THEY ARE NEEDED
IGNORES SIGNAL TO STOP
DON'T DIE
DO NOT MATURE NORMALLY

Front 2

PROTO-ONONGENES

Back 2

ANYTHING INVOLVED IN THE REGULATION OF CELL DIVISION WHICH IS NORMAL

Front 3

ONCOGENES

Back 3

MUTATED PROTO-ONCOGENES

Front 4

TO STOP A CELL FROM DIVIDING YOU CAN DO

Back 4

1. GIVE A DRUG THAT STOPS OTHER CELLS FROM MAKING GROWTH FACTOR
2. GIVE A DRUG THAT BLOS THE GROWTH FACTOR RECEPTORS
3. GIVE A DRUG THAT INACTIVATES GROWTH FACTORS IN EXTRACELLULAR FLUID

Front 5

CANCER CAN BE INTRACELLULAR OR EXTRACELLULAR

Back 5

THAT IS WHY EXTRACELLULAR TX DOESN'T ALWAYS WORK

Front 6

DIFFERENTIATED CELLS TYPICALLY PRODUCE

Back 6

BENIGN TUMORS

Front 7

UNDIFFERENTIATED RAPIDLY DIVIDING CELLS PRODUCE

Back 7

MALIGNANT TUMORS

Front 8

BENIGN TUMORS

Back 8

1. CONTAIN CELLS THAT LOOK NORMAL TISSUE
2. MAY LEAD TO OVERSECRETION OF HORMONES
3. ENCAPSULATED
4. GENERALLY DON'T INVADE NEIGHBORS
5. CAN CAUSE DMAGE NEARBY ORGANS BY COMPRESSING

Front 9

MALIGNANT TUMORS

Back 9

1.CELLS DON'T LOOK LIKE NORMAL ADULT CELLS
2. RAPID DIVISION
3.INVADES NEIGHBORING TISSUE
4. SECRETES HORMONES ASSOCIATED WITH OTHER TISSUES
5.COMPRESS SURROUNDING TISSUE

Front 10

METASTASIS

Back 10

GENERALLY OCCURS IN LOW FLOW BLOOD AREAS, BONES, BRAIN, LUNGS LIVER

Front 11

LOCAL EFFECTS OF TUMOR GROWTH INCLUDE

Back 11

1.BLEEDING - ANGIOGENESIS (MAKE NEW BLOOD VESSELS)
2. COMPRESS LYMPH VESSELS
3.COMPRESSION OF HOLLOW ORGANS
4. COMPRESSION OF NERVES

Front 12

MANIFESTATIONS OF CA

Back 12

1. CHANGES IN ORGAN FUNCTION
2.LOCAL EFFECTS OF TUMORS
3.ECTOPIC HORMONES SECRETED BY TUMOR CELL
4.TISSUE BREAKDOWN - PROTEIN WASTING, BONE BREAKDOWN

Front 13

EFFECTS OF CA

Back 13

WEIGHT LOSS
MUSCLE WASTING
WEAKNESS
ANOREXIA
ANEMIA