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109 Cards in this Set
- Front
- Back
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DA uses
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Anti depression
Anti psychotic Fatigue suppression Appetite suppression Enhanced attention Motor dysfunction Pressor effects |
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Indatraline and Cocaine
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Reuptake inhibitor for DAT, NET, and SET
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Buproprion (antidepressant welbutrin)
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Reuptake inhibitor for DAT and NET
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Duloxetine (Cymbolta)
nomifensine (meritol) |
Reuptake inhibitor for DAT
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Amphetamine and analogs
dexadrine meth amphetamine methylphenidate (ritalin) |
Reuptake inhibitor for DAT
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Dihydrexadine
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D1 and D5 agonist
G protein:Gs |
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apopmorphine (anti parkinson)
lisuride (anti parkinson & migrane) |
DA agonist D1-D5 receptors
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DA specific neurotoxin
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MPTP-->MPP+
6OHDA |
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fenoldapam (BP effects)
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DA agonist D1 receptos
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Duloxetine (Cymbolta)
nomifensine (meritol) Amphetamine and analogs dexadrine meth amphetamine methylphenidate (ritalin) |
Reuptake inhibitor for DAT
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Pergolide
Bromocriptine |
DA agonist D 2,3,4
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Resirpine
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From the DA lecture
VDAT inhibitor (blocks vesicular filling of all biogenic amines) |
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Oubain
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Na/K atpase inhibitor indirectly inhibits Synaptic DAT which is Na and Cl dependent cotransporter
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Ropinerole (requip)
pramipexole (mirapex) Quinpirole |
DA agonist D2,3
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Spiperone
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DA antagonist D1-5
5HT1a |
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Ecopipam
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DA antagonist D1
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Domperidone
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DA antagonist D2,3,4
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Amilsulpride
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DA antagonist D2,3
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Narcoleptics
Chlorpramazine (thorazine) Trifluoperazine Piperazine Risperidone |
DA antagonistD2,3,4
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Clozapine
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DA antagonist D4
5HT 4 like antagonist the 6 and 7 but not 4 |
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NE uses
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Anti depressant
OCD ADHD Decongestant Bronchial dialation Cariac rhythm V and rate Hypertension |
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Venlafexine
clomipramine |
NET and SET reuptake inhibitor
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Imipramine
Amitriptyline Viloxazine Atomoxetine (strettera) |
NET reuptake Inhibitor
Tricyclic Atypical |
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Befloxatone
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MAO A reversible NE and 5HT
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Clorgyline
harmiline |
MAO A irreversible
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Iprodiazid
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MAO Non specific irreversible
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Selegiline/deprenyl
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MAO B irreversible
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Tolcapone
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COMTI irreversible
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G protein
a1 a2 B |
A1=Gq
A2=Gi B=Gs |
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DA
NE Epi Phenylephrine Ephedrine |
a1 selective agonists
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Tetrahydrazine
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a1A Agonist
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nigoldipine
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a1A antagonist
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Cyclazosin
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a1B antagonist
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phentolamine
prazosin |
a1 and a2 antagonist
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phenoxybenzamine
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a1 suicide antagonist
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NE
Epi Clonidine |
non selective a2 agonist
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oxymetazoline
ephedrine LSD 25 |
a2A partial agonist
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Imiloxan
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NE alpha 2b antagonist
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Rauwolscine
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NE alpha 2c antagonist
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phentolomine
prazosin yohimbine |
NE alpha 2 antagonist
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a2 beta gamma subunit activity
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inactivate VDCCs and activate CDKCs
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NE
Epi isoproterenol ephedrine psudophedrine |
NE beta receptor agonists
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albuterol
salmeterol |
b2 agonist
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atenolol
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b1 antagonist
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Butoxamine
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b2 antagonist
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Bupranolol
alprenolol |
NE beta receptor non selective antagonist
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Gs
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NE b receptor,
DA D1 and D5 receptors 5HT 4 like receptors |
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Gi
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DA D2,D3,D4 receptors
NE Alpha 2 receptors opiod receptors Canabinoid receptors 5HT 1 receptors (5HT is also Go) |
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Biogenic amine degradative pathways
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COMT then MAO to HVA
or MAO+aldehyde deoh then COMT to HVA |
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TH is used
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To make tyrosine into L-DOPA
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AAADC is used and blocked by
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to turn l DOPA into DA
to turn l tryptamine into 5HT blocked by CARBIDOPA |
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DBH is used
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DA to NE
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PNMT
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NE to Epi
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Tryptophan hydroxylase
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Tryptophan to L tryptamine
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MAO -As degrade
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NE and 5HT
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MAO- Bs degrade
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DA and HA
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AD (aldehyde dehydrogenase)dose and
is blocked by?? |
blocked by disulfiram
SERITONIN 5 indolacetaldehyde to 5 indolacetic acid ALCOHOL acetealdehyde to acetic acid |
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Fenfluramine
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blocks tryptophan OHase and both synaptic and vesicular 5HT transporters
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Fluoxetine (prozac)
Sertraline (zoloft) Citalopram (celexa) Paroxetine (Paxil) Fluvoxamine (luvox) |
SET reuptake inhibitors
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5HT
Quipazine |
5HT1, 2, 3, and 4 agonists
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LSD-25
psilocybin psilocin |
5HT1 partial agonist
5HT 2 A and C |
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Buspirone (anxiolytic)
DPAT bufotenin DMT |
5HT1A full agonist
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Ergotamine
methysergide Sumatriptan |
5HT1B ful agonist
anti migrane |
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Spiperone
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5HT1A antagonist
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Isamoltane
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5HT1B and D antagonist
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Methiothepin
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5HT1E and F antagonist
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Pindolol
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non selective 5HT1 antagonist
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5HT 1 G protein
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Gi/o
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5HT
a-me-5-HT quipazine |
5HT 2 non selective agonists
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LSD-25
psilocin psilocybin psychedelic phenylethylamines |
5HT2A and C partial agonists
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Psychedelic phenylethylamines
(not super important) |
naming a few mentioned in class:
cathine ephedrine LSD-25 5HT yohimbine mescaline elimicin MDMA |
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DMT
DOI DOB DOM |
5HT2A full agonists
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agomelatine
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5HT 2c agonist
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Ketanserin
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5HT2A antagonist
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Metergoline
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5HT2B antagonists
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Ritanserin
methysergide |
5HT2C antagonist
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mesulsergin
dibenzyline |
5HT2 non selective antagonist
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5HT2 g protein
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Gq
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Idolominergic psychodelics and if you block this receptor you block the psychedelic effect
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DMT 5HT
bufotenin psilocybin LSD 25 5HT2A |
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5HT uses
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antischizophrenics (5HT 2A antagonist)
satiety stimulants (5HT2C agonist) |
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CBG
2-me-5-HT |
5HT3 agonist
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ondansetron
zacopride |
5HT3 antagonist
antiemetics nootropics |
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pentameric cation ch with weak selectivity for Na
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5HT3 receptors
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LSD 25
methysergide |
5HT6 partial agonist
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8oh DPAT
psilocin psilocybin methysergide |
5HT7 partial agonist
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EMDT
CTST |
5HT6 full agonist
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COAT
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5HT7 full agonist
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amoxipine
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5HT6 antagonist
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5HT4 like (4,6,7) mechanism
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Gs
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5HT
LSD25 Coat |
5HT5 A and B agonist
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5HT neurotoxin
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PCPA
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melotonin
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serotonin to n acetyl 5HT to meletonin
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Leu and met enkephalin
Deltorphins THP |
Delta
op1 dop 1 and 2 endogenous agonist |
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Dynorphin A
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Kappa
OP2 KOP1 KOP2 endogenous agonist |
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Brandorphin
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Mu
OP3 MOP1 MOP2 endogenous agonist |
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Nociceptin (orphanin)
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ORL
OP4 NOP endogenous agonist |
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Naloxone
Diprenorphine naltrexone |
opioate Antagonist
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Opiate g protein mechanism
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Gi/o OpIOd
same as 5HT1 |
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narcotine
codeine Papaverin thebaine morphine |
exogenous organic opium alkaloids
Did he give a receptor??? |
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hydromorphone (dilaudid)
Diacetyl morphine (heroin) oxycodone (percodan, oxycontin) Hydrocodone (vicodin) |
modified opiates
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fentanyl
meperdine (demerol) Propoxyphene (darvon) methadone (dolophine) buprenorphine (buprenox) (partial) |
synthetic opiates
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Salicylates: asprin
Traditional : acetaminophen ibuprofen naproxen Cox1 gastric and inflammatory cox2 inflammatory and cardiac |
NSAID's
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celebrex (celecoxib)
Vioxx (rofecoxib) Bextre (caldecoxib) |
dangerous Cox 2 inhibitors
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Anandamide
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endogenous cannabinoid CB1 and 2 agonist
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THC
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cannabinoid CB1 and 2 agonist
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canibinoid G protein
alpha and beta gamma |
Gi
decrease N and Q VDCC and increase KIR VDKC (not important anomalous inward rectifier) |
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LSD-25
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partial agonist for:
NE alpha 2 5HT1 partial 5HT2a/c partial 5HT6 Partial |
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Psilocybin
psilocin |
partial agonist for:
NE alpha 2 5HT1 partial 5HT2a/c partial 5HT7 Partial |
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Methysergide
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5HT 1B agonist
5HT2c antagonist 5HT 6/7 partial agonist |
