Usyd Block 7 (Endo) - Drug Quiz

Front 1

Dobutamine

Back 1

- (Beta1 agonist)

Front 2

metoprolol

Back 2

- (beta 1 selective antagonist)

Front 3

carbimazole

Back 3

thyrotoxicosis - (block peroxidase activity, prevents organification of iodide, stops couping of molecules that form T3)

Front 4

propyl-thiouracil (PTU)

Back 4

thyrotoxicosis - (block peroxidase activity, prevents organification of iodide, stops couping of molecules that form T3)

Front 5

neomercazole

Back 5

thyrotoxicosis - (trade name of preferred carbimazole. Except in first trimester of pregnancy)

Front 6

thyroxine

Back 6

hypothyroidism - (acts as endogenous thyroid hormones.)

Front 7

Syntocinon

Back 7

induce labour - (synthetic oxytocin)

Front 8

Atosiban

Back 8

Halt labour - (oxytocin Rc anatgonist)

Front 9

Cabergoline

Back 9

DA agonist - Prolactinoma,
PD - initial therapy option

Front 10

Octreotide

Back 10

GH secreting tumours - (analogue of somatostatin, decreases GH lvls and tumour size)

Front 11

Ketoconazole

Back 11

Cushing's disease - (anti-fungal which inhibits steroidogenesis)

Front 12

melatonin

Back 12

sleep disorders, blind persons - (light dark cycle regulation)

Front 13

Leptin

Back 13

congenital leptin deficiency - (acts as endogenous leptin, sub cut administration --> not effective in common obesity)

Front 14

budesonide, ciclesonide

Back 14

long term asthma - (GCS)

Front 15

fluticasone

Back 15

long term asthma - (action of GCS)

Front 16

Dexamethasone, betamethasone

Back 16

- (action of GCS, preferred in the treatment of cerebral oedema in pts with brain tumours (dex))

Front 17

hydrocortisone

Back 17

addisons, anaphylaxis - (endogenous glucocorticoid activity)

Front 18

fludrocortisone

Back 18

addisons - (mineralocorticoid actions)

Front 19

metyrapone

Back 19

Dx of adrenal insufficiency, sometimes Tx of cushings - (inhibits cortisol synthesis via 11 β hydroxylase)

Front 20

9-α fluorinated corticosteroids

Back 20

- (worse for steroid myopathy --> changing to prednisone produces improvement)

Front 21

Sulphonylureas

Back 21

Diabetes type 2 - (closes K⁺ channel on β islet cells --> membrane potential lost, Ca²⁺ influx --> insulin release)

Front 22

Statins

Back 22

Diabetes - (HMG-CoA reductase inhibtor)

Front 23

Insulin

Back 23

Diabetes - (Works as endogenous insulin.)

Front 24

imidazoles

Back 24

anti-fungal - ( -zole suffix, topical usually poorly absorbed and used for mild - moderate infevtion, can be given orally or IV)

Front 25

amphotericin

Back 25

anti-fungal - (possible use topically, most often IV administration)

Front 26

Metformin

Back 26

Diabetes type 2 - (increase glucose uptake in muscle and fat, suppresses appetite, decreases glucose absorption from gut, decreased gluconeogenesis)

Front 27

Arcarbose

Back 27

- (decreased glucose uptake from gut via inhibition of enzyme which breaks down carbohydrate)

Front 28

Rosiglitazone, pioglitazone (Glitazones)

Back 28

- (Act on PPARg in fat cells, reduces insulin resistance)

Front 29

sitagliptin

Back 29

DPP-4 inhibitor - (prevent GLP-1 proteolysis)

Front 30

Prostaglandin synthetase inhibitors

Back 30

Abnormal uterine bleeding - (inhibit synthesis of prostaglandin, also interfere with myometrial prostaglandin E2 binding)

Front 31

Norethisterone

Back 31

Abnormal uterine bleeding - (Is a progesterone, can be used in combo or stand alone)

Front 32

Dydrogesterone

Back 32

Abnormal uterine bleeding - ()

Front 33

Depo Provera

Back 33

Abnormal uterine bleeding/contraception - (progesterone only contraceptive)

Front 34

Implanon

Back 34

abnormal bleedin', contraception - (inhibit ovulation)
contains etonogestrel (a progestin)

Front 35

Danazol

Back 35

abnormal uterine bleeding - (inhibits endometrial proliferation causing endometrial atrophy)

Front 36

Goserelin, Nafarelin

Back 36

GnRH agonist - (initial agonist of pituitary, followed by 'exhaustion' --> hypogonadotrophic hypogonadism))

Front 37

Tranexamic acid

Back 37

Abnormal uterine bleeding - (antifibrinolytic - inhibit plasminogen activator)