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14 Cards in this Set
- Front
- Back
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Gastrin
Release: Stimulus, Location |
G-cells in the Antrum
Released in response to: 1. DISTENTION of STOMACH 2. Increased acid 3. Presence of AA |
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Secretin
Release: Stimulus, Location |
S cells in duodenum
Released in response to: Duodenal acidity to increase bicarbonate secretion from pancreas |
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Cholecystokinin
Release: Stimulus, Location |
CCK, I cells in the duodenum
Released in response to: Fat and protein digestion in duodenum Contracts gall bladder, increases enzyme secretion from acinar cells, has similar effects to Gastrin |
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Glucose-dependent insulinotropic peptide (GIP) (also called gastric inhibitory peptide)
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Released from Duodenum
Primes insulin release in anticipation of the nutrient absorption |
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Motilin
Release: Stimulus, Location |
(M cells in the lower stomach and duodenum)
Involved in fasting contractions in the stomach and intestines |
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Vasoactive intestinal polypeptide (VIP)
Release: Stimulus, Location |
Shares some effects with Secretin and increases bicarbonate secretion from pancreatic duct
NT in ENS acting to increase intestinal secretion and inhibit smooth muscle contraction |
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Neurotensin and polypeptide Y (PYY)
Release: Stimulus, Location |
Released from the ileum in response to fat to slow intestinal motility (ileal break)
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Gastrin-releasing peptide (GRP)
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Present in vagal terminal cells that innervate G-Cells. Increases Gastrin release from G-cells
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Somatostatin
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Released from D cells in the stomach
Diffuse through the extracellular space to target cells (paracrine effect) Inhibits the release of Gastrin from G cells |
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Peptide Family:
Gastrin Family Members: Shared Sequence Second Messenger |
Peptide Family:
Gastrin Family Gastrin and CCK Share a common polypeptide sequence at carboxy terminal of chain Calcium is the secondary messenger |
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Peptide Family:
Secretin Family Members: Second Messenger |
Secretin Family
VIP, pancreatic glucagon, GIP cAMP is the secondary messenger |
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Peptides released from Antrum of Stomach
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Gastin
VIP Substance P Somatostatin Gastric-releasing peptide (GRP) |
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Peptides released from Duodenum
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Glucagon
Secretin CCK GIP Motilin |
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Peptides released from Jujenum/Ileum?
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Neurotensin
(in response to fat to slow intestinal motility - ileal break) |
