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12 Cards in this Set
- Front
- Back
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Tumor supressors
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Loss of function
both alleles must be affected |
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Gene
Rb |
Chromosome: 13q
Tumor: Retinoblastoma, Osteosarcoma |
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|
Gene
BRCA1 |
Chromosome: 17q
Tumor: Breast, Ovarian |
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Gene
BRCA2 |
Chromosome: 13q
Tumor: Breast |
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|
Gene
p53 |
Chromosome: 17p
Tumor: Most human cancers, Li-Fraumeni syndrome |
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Gene
p16 |
Chromosome: 9p
Tumor: Melanoma |
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Gene
APC |
Chromosome: 5q
Tumor: Colorectal Cancer (associated with FAP) |
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Gene
WT1 |
Chromosome: 11p
Tumor: Wilm's tumor |
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|
Gene
NF1 |
Chromosome: 17q
Tumor: Neurofibromatosis Type 1 |
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Gene
NF2 |
Chromosome: 22q
Tumor: Neurofibromatosis Type 2 |
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Gene
DPC |
Chromosome: 18q
Tumor: Pancreatic cancer |
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|
Gene
DCC |
Chromosome: 18q
Tumor: Colon Cancer |
