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469 Cards in this Set

  • Front
  • Back

Classic ECG finding in atrial flutter

“Sawtooth” P waves
Definition of unstable angina
Angina is new, is worsening, or occurs at rest
Antihypertensive for a diabetic patient with proteinuria
ACEI
Beck’s triad for cardiac tamponade
Hypotension, distant heart sounds, and JVD
Drugs that slow AV node transmission
β-blockers, digoxin, calcium channel blockers
Hypercholesterolemia treatment that → flushing and pruritis
Niacin
Treatment for atrial fibrillation
Anticoagulation, rate control, cardioversion
Treatment for ventricular fibrillation
Immediate cardioversion
Autoimmune complication occurring 2–4 weeks post-MI
Dressler’s syndrome: fever, pericarditis, ↑ ESR
IV drug use with JVD and holosystolic murmur at the left sternal border. Treatment?
Treat existing heart failure and replace the tricuspid valve
Diagnostic test for hypertrophic cardiomyopathy
Echocardiogram (showing thickened left ventricular wall and outflow obstruction)
A fall in systolic BP of > 10 mmHg with inspiration
Pulsus paradoxus (seen in cardiac tamponade)
Classic ECG findings in pericarditis
Low-voltage, diffuse ST-segment elevation
Definition of hypertension
BP > 140/90 on three separate occasions two weeks apart
Eight surgically correctable causes of hypertension
Renal artery stenosis, coarctation of the aorta, pheochromocytoma, Conn’s syndrome, Cushing’s syndrome, unilateral renal parenchymal disease, hyperthyroidism, hyperparathyroidism
Evaluation of a pulsatile abdominal mass and bruit
Abdominal ultrasound and CT
Indications for surgical repair of abdominal aortic aneurysm
> 5
Treatment for acute coronary syndrome
Morphine, O2, sublingual nitroglycerin, ASA, IV β-blockers, heparin
What is the metabolic syndrome?
Abdominal obesity, high triglycerides, low HDL, hypertension, insulin resistance, prothrombotic or proinflammatory states
50-year-old male with angina can exercise to 85% of maximum predicted heart rate. What test?
Exercise stress treadmill with ECG
65-year-old woman with left bundle branch block and sever osteoarthritis has unstable angina. What test?
Pharmacologic stress test (e.g. , dobutamine echo)
Target LDL in a patient with diabetes
< 70
Signs of active ischemia during stress testing
Angina, ST-segment changes on ECG, or ↓ BP
ECG findings suggesting MI
ST-segment elevation (depression means ischemia), flattened T waves, and Q waves
A young patient has angina at rest with ST-segment elevation. Cardiac enzymes are normal
Prinzmetal’s angina
Common symptoms associated with silent MIs
CHF, shock, and altered mental status
The diagnostic test for pulmonary embolism
V/Q scan
An agent that reverses the effects of heparin
Protamine
The coagulation parameter affected by warfarin
PT
A young patient with a family history of sudden death collapses and dies while exercising
Hypertrophic cardiomyopathy
Endocarditis prophylaxis regimens
Oral surgery—amoxicillin; GI or GU procedures—ampicillin and gentamicin before and amoxicillin after
The 6 P’s of ischemia due to peripheral vascular disease
Pain, pallor, pulselessness, paralysis, paresthesia, poikilothermia
Virchow’s triad
Stasis, hypercoagulability, endothelial damage
The most common cause of hypertension in young women
OCPs
The most common cause of hypertension in young men
Excessive EtOH
“Stuck-on” appearance
Seborrheic keratosis
Red plaques with silvery-white scales and sharp margins
Psoriasis
The most common type of skin cancer; the lesion is a pearly-colored papule with a translucent surface and telangiectasias
Basal cell carcinoma
Honey-crusted lesions
Impetigo
A febrile patient with a history of diabetes presents with a red, swollen, painful lower extremity
Cellulitis
(+) Nikolsky’s sign
Pemphigus vulgaris
(-) Nikolsky’s sign
Bullous pemphigoid
A 55-year-old obese patient presents with dirty, velvety patches on the back of the neck
Acanthosis nigricans. Check fasting blood sugar to rule out diabetes
Dermatomal distribution
Varicella zoster
Flat-topped papules
Lichen planus
Iris-like target lesions
Erythema multiforme
A lesion characteristically occurring in a linear pattern in areas where skin comes into contact with clothing or jewelry
Contact dermatitis
Presents with a herald patch, Christmas-tree pattern
Pityriasis rosea
A 16-year-old presents with an annular patch of alopecia with broken-off, stubby hairs
Alopecia areata (autoimmune process)
Pinkish, scaling, flat lesions on the chest and back. KOH prep has a “spaghetti-and-meatballs” appearance
Pityriasis versicolor
Four characteristics of a nevus suggestive of melanoma
Asymmetry, border irregularity, color variation, large diameter
Premalignant lesion from sun exposure that can → squamous cell carcinoma
Actinic keratosis
“Dewdrop on a rose petal"
Lesions of 1° varicella
“Cradle cap"
Seborrheic dermatitis. Treat with antifungals
Associated with Propionibacterium acnes and changes in androgen levels
Acne vulgaris
A painful, recurrent vesicular eruption of mucocutaneous surfaces
Herpes simplex
Inflammation and epithelial thinning of the anogenital area, predominantly in postmenopausal women
Lichen sclerosus
Exophytic nodules on the skin with varying degrees of scaling or ulceration; the second most common type of skin cancer
Squamous cell carcinoma
The most common cause of hypothyroidism
Hashimoto’s thyroiditis
Lab findings in Hashimoto’s thyroiditis
High TSH, low T4, antimicrosomal antibodies
Exophthalmos, pretibial myxedema, and ↓ TSH
Graves’ disease
The most common cause of Cushing’s syndrome
Iatrogenic steroid administration. The second most common cause is Cushing’s disease
A patient presents with signs of hypocalcemia, high phosphorus, and low PTH
Hypoparathyroidism
“Stones, bones, groans, psychiatric overtones"
Signs and symptoms of hypercalcemia
A patient complains of headache, weakness, and polyuria; exam reveals hypertension and tetany. Labs reveals hypernatremia, hypokalemia, and metabolic alkalosis
1° hyperaldosteronism (due to Conn’s syndrome or bilateral adrenal hyperplasia)
A patient presents with tachycardia, wild swings in BP, headache, diaphoresis, altered mental status, and a sense of panic
Pheochromocytoma
Should α- or β-antagonists be used first in treating pheochromocytoma?
α-antagonists (phentolamine and phenoxybenzamine)
A patient with a history of lithium use presents with copious amounts of dilute urine
Nephrogenic diabetes insipidus (DI)
Treatment of central DI
Administration of DDAVP ↓ serum osmolality and free water restriction
A postoperative patient with significant pain presents with hyponatremia and normal volume status
SIADH due to stress
An antidiabetic agent associated with lactic acidosis
Metformin
A patient presents with weakness, nausea, vomiting, weight loss, and new skin pigmentation hyponatremia and hyperkalemia. Treatment?
1° adrenal insufficiency (Addison’s disease). Treat with replacement glucocorticoids, mineralocorticoids, and IV fluids
Goal hemoglobin A1c for a patient with DM
< 7.0
Treatment of DKA
Fluids, insulin, and aggressive replacement of electrolytes (e.g. K+)
Why are β-blockers contraindicated in diabetics?
They can mask symptoms of hypoglycemia
Bias introduced into a study when a clinician is aware of the patient's treatment type
Observational bias
Bias introduced when screening detects a disease earlier and thus lengthens the time from diagnosis to death
Lead-time bias
If you want to know if race affects infant mortality rate but most of the variation in infant mortality is predicted by socioeconomic status, then socioeconomic status is a _____.
Confounding variable
The number of true positives divided by the number of patients with the disease is _____.
Sensitivity
Sensitive tests have few false negatives and are used to rule _____ a disease.
Out
PPD reactivity is used as a screening test because most people with TB (except those who are anergic) will have a + PPD. Highly sensitive or specific?
Highly sensitive for TB
Chronic diseases such as SLE—higher prevalence or incidence?
Higher prevalence
Epidemics such as influenza—higher prevalence or incidence?
Higher incidence
Cross-sectional survey—incidence or prevalence?
Prevalence
Cohort study—incidence or prevalence?
Incidence and prevalence
Case-control study—incidence or prevalence?
Neither
Describe a test that consistently gives identical results, but the results are wrong
High reliability, low validity
Difference between a cohort and a case-control study
Cohort studies can be used to calculate relative risk (RR), incidence, and/or odds ratio (OR). Case-control studies can be used to calculate an OR
Attributable risk?
The incidence rate (IR) of a disease in exposed − the IR of a disease in unexposed
Relative risk?
The IR of a disease in a population exposed to a particular factor ÷ the IR of those not exposed
Odds ratio?
The likelihood of a disease among individuals exposed to a risk factor compared to those who have not been exposed
Number needed to treat?
1 ÷ (rate in untreated group − rate in treated group)
In which patients do you initiate colorectal cancer screening early?
Patients with IBD; those with familial adenomatous polyposis (FAP)/hereditary nonpolyposis colorectal cancer (HNPCC); and those who have first-degree relatives with adenomatous polyps (< 60 years of age) or colorectal cancer
The most common cancer in men and the most common cause of death from cancer in men
Prostate cancer is the most common cancer in men, but lung cancer causes more deaths
The percentage of cases within one SD of the mean? Two SDs? Three SDs?
68%, 95.5%, 99.7%
Birth rate?
Number of live births per 1000 population
Fertility rate?
Number of live births per 1000 women 15–44 years of age
Mortality rate?
Number of deaths per 1000 population
Neonatal mortality?
Number of deaths from birth to 28 days per 1000 live births
Postnatal mortality?
Number of deaths from 28 days to one year per 1000 live births
Infant mortality?
Number of deaths from birth to one year of age per 1000 live births (neonatal + postnatal mortality)
Fetal mortality?
Number of deaths from 20 weeks’ gestation to birth per 1000 total births
Perinatal mortality?
Number of deaths from 20 weeks’ gestation to one month of life per 1000 total births
Maternal mortality?
Number of deaths during pregnancy to 90 days postpartum per 100,000 live births
True or false: Once patients sign a statement giving consent, they must continue treatment
False. Patients may change their minds at any time. Exceptions to the requirement of informed consent include emergency situations and patients without decision-making capacity
A 15-year-old pregnant girl requires hospitalization for preeclampsia. Should her parents be informed?
No. Parental consent is not necessary for the medical treatment of pregnant minors
A doctor refers a patient for an MRI at a facility he/she owns
Conflict of interest
Involuntary psychiatric hospitalization can be undertaken for which three reasons?
The patient is a danger to self, a danger to others, or gravely disabled (unable to provide for basic needs)
True or false: Withdrawing life-sustaining care is ethically distinct from withholding sustaining care
False. Withdrawing and withholding life are the same from an ethical standpoint
When can a physician refuse to continue treating a patient on the grounds of futility?
When there is no rationale for treatment, maximal intervention is failing, a given intervention has already failed, and treatment will not achieve the goals of care
An eight-year-old child is in a serious accident. She requires emergent transfusion, but her parents are not present.
Treat immediately. Consent is implied in emergency situations.
Conditions in which confidentiality must be overridden
Real threat of harm to third parties; suicidal intentions; certain contagious diseases; elder and child abuse
Involuntary commitment or isolation for medical treatment may be undertaken for what reason?
When treatment noncompliance represents a serious danger to public health (e.g., active TB)
A 10-year-old child presents in status epilepticus, but her parents refuse treatment on religious grounds
Treat because the disease represents an immediate threat to the child’s life. Then seek a court order.
A son asks that his mother not be told about her recently discovered cancer
A patient’s family cannot require that a doctor withhold information from the patient
Patient presents with sudden onset of severe, diffuse abdominal pain. Exam reveals peritoneal signs and AXR reveals free air under the diaphragm. Management?
Emergent laparotomy to repair perforated viscus, likely stomach
The most likely cause of acute lower GI bleed in patients > 40 years old
Diverticulosis
Diagnostic modality used when ultrasound is equivocal for cholecystitis
HIDA scan
Sentinel loop on AXR
Acute pancreatitis
Risk factors for cholelithiasis
Fat, female, fertile, forty, flatulent
Inspiratory arrest during palpation of the RUQ
Murphy’s sign, seen in acute cholecystitis
Most common organism
Campylobacter
Recent antibiotic use
Clostridium difficile
Camping
Giardia
Traveler’s diarrhea
ETEC
Church picnics/mayonnaise
S. aureus
Uncooked hamburgers
E. coli O157:H7
Fried rice
Bacillus cereus
Poultry/eggs
Salmonella
Raw seafood
Vibrio, HAV
AIDS
Isospora, Cryptosporidium, Mycobacterium avium complex (MAC)
Pseudoappendicitis
Yersinia
A 25-year-old Jewish male presents with pain and watery diarrhea after meals. Exam shows fistulas between the bowel and skin and nodular lesions on his tibias.
Crohn’s disease
Inflammatory disease of the colon with ↑ risk of colon cancer
Ulcerative colitis
Extraintestinal manifestations of IBD
Uveitis, ankylosing spondylitis, pyoderma gangrenosum, erythema nodosum, 1° sclerosing cholangitis
Medical treatment for IBD
5-aminosalicylic acid agents and steroids during acute exacerbations
Difference between Mallory-Weiss and Boerhaave tears
Mallory-Weiss—superficial tear in the esophageal mucosa; Boerhaave—full-thickness esophageal rupture
Charcot’s triad
RUQ pain, jaundice, and fever/chills in the setting of ascending cholangitis
Reynolds’ pentad
Charcot’s triad plus shock and mental status changes, with suppurative ascending cholangitis
Medical treatment for hepatic encephalopathy
↓ protein intake, lactulose, neomycin
First step in the management of a patient with acute GI bleed
Establish the ABCs
A four-year-old child presents with oliguria, petechiae, and jaundice following an illness with bloody diarrhea. Most likely diagnosis and cause?
Hemolytic-uremic syndrome (HUS) due to E. coli O157:H7
Post-HBV exposure treatment
HBV immunoglobulin
Classic causes of drug-induced hepatitis
TB medications (INH, rifampin, pyrazinamide), acetaminophen, and tetracycline
A 40-year-old obese female with elevated alkaline phosphatase, elevated bilirubin, pruritus, dark urine, and clay-colored stools
Biliary tract obstruction
Hernia with highest risk of incarceration—indirect, direct, or femoral?
Femoral hernia
A 50-year-old man with a history of alcohol abuse presents with boring epigastric pain that radiates to the back and is relieved by sitting forward. Management?
Confirm the diagnosis of acute pancreatitis with elevated amylase and lipase. Make the patient NPO and give IV fluids, O2, analgesia, and “tincture of time”
Four causes of microcytic anemia
TICS—Thalassemia, Iron deficiency, anemia of Chronic disease, and Sideroblastic anemia
An elderly male with hypochromic, microcytic anemia is asymptomatic. Diagnostic tests?
Fecal occult blood test and sigmoidoscopy; suspect colorectal cancer
Precipitants of hemolytic crisis in patients with G6PD deficiency
Sulfonamides, antimalarial drugs, fava beans
The most common inherited cause of hypercoagulability
Factor V Leiden mutation
The most common inherited hemolytic anemia
Hereditary spherocytosis
Diagnostic test for hereditary spherocytosis
Osmotic fragility test
Pure RBC aplasia
Diamond-Blackfan anemia
Anemia associated with absent radii and thumbs, diffuse hyperpigmentation, café-au-lait spots, microcephaly, and pancytopenia
Fanconi’s anemia
Medications and viruses that → aplastic anemia
Chloramphenicol, sulfonamides, radiation, HIV, chemotherapeutic agents, hepatitis, parvovirus B19, EBV
How to distinguish polycythemia vera from 2° polycythemia
Both have ↑ hematocrit and RBC mass, but polycythemia vera should have normal O2 saturation and low erythropoietin levels
Thrombotic thrombocytopenic purpura (TTP) pentad?
Pentad of TTP—“FAT RN”: Fever, Anemia, Thrombocytopenia, Renal dysfunction, Neurologic abnormalities
HUS triad?
Anemia, thrombocytopenia, and acute renal failure
Treatment for TTP
Emergent large-volume plasmapheresis, corticosteroids, antiplatelet drugs
Treatment for idiopathic thrombocytopenic purpura (ITP) in children
Usually resolves spontaneously; may require IVIG and/or corticosteroids
Which of the following are ↑ in DIC: fibrin split products, D-dimer, fibrinogen, platelets, and hematocrit
Fibrin split products and D-dimer are elevated; platelets, fibrinogen, and hematocrit are ↓
An eight-year-old boy presents with hemarthrosis and ↑ PTT with normal PT and bleeding time. Diagnosis? Treatment?
Hemophilia A or B; consider desmopressin (for hemophilia A) or factor VIII or IX supplements
A 14-year-old girl presents with prolonged bleeding after
von Willebrand’s disease; treat with desmopressin, FFP, or cryoprecipitate
A 60-year-old African-American male presents with bone pain. Workup for multiple myeloma might reveal?
Monoclonal gammopathy, Bence Jones proteinuria, “punched-out” lesions on x-ray of the skull and long bones
Reed-Sternberg cells
Hodgkin’s lymphoma
A 10-year-old boy presents with fever, weight loss, and night sweats. Examination shows anterior mediastinal mass. Suspected diagnosis?
Non-Hodgkin’s lymphoma
Microcytic anemia with ↓ serum iron, ↓ total iron-binding capacity (TIBC), and normal or ↑ ferritin
Anemia of chronic disease
Microcytic anemia with ↓ serum iron, ↓ ferritin, and ↑ TIBC
Iron deficiency anemia
An 80-year-old man presents with fatigue, lymphadenopathy, splenomegaly, and isolated lymphocytosis. Suspected diagnosis?
Chronic lymphocytic leukemia (CLL)
A late, life-threatening complication of chronic myelogenous leukemia (CML)
Blast crisis (fever, bone pain, splenomegaly, pancytopenia)
Auer rods on blood smear
Acute myelogenous leukemia (AML)
AML subtype associated with DIC
M3
Electrolyte changes in tumor lysis syndrome
↓ Ca2+, ↑ K+, ↑ phosphate, ↑ uric acid
Treatment for AML M3
Retinoic acid
A 50-year-old male presents with early satiety, splenomegaly, and bleeding. Cytogenetics show t(9,22). Diagnosis?
CML
Heinz bodies?
Intracellular inclusions seen in thalassemia, G6PD deficiency, and postsplenectomy
An autosomal-recessive disorder with a defect in the GPIIbIIIa platelet receptor and ↓ platelet aggregation
Glanzmann’s thrombasthenia
Virus associated with aplastic anemia in patients with sickle cell anemia
Parvovirus B19
A 25-year-old African-American male with sickle cell anemia has sudden onset of bone pain. Management of pain crisis?
O2, analgesia, hydration, and, if severe, transfusion
A significant cause of morbidity in thalassemia patients. Treatment?
Iron overload; use deferoxamine
The three most common causes of fever of unknown origin (FUO)
Infection, cancer, and autoimmune disease
Four signs and symptoms of streptococcal pharyngitis
Fever, pharyngeal erythema, tonsillar exudate, lack of cough
A nonsuppurative complication of streptococcal infection that is not altered by treatment of 1° infection
Postinfectious glomerulonephritis
Asplenic patients are particularly susceptible to these organisms
Encapsulated organisms––pneumococcus, meningococcus, Haemophilus influenzae, Klebsiella
The number of bacteria on a clean-catch specimen to diagnose a UTI
10^5 bacteria/mL
Which healthy population is susceptible to UTIs?
Pregnant women. Treat this group aggressively because of potential complications
A patient from California or Arizona presents with fever, malaise, cough, and night sweats. Diagnosis? Treatment?
Coccidioidomycosis. Amphotericin B
Nonpainful chancre
1° syphilis
A “blueberry muffin” rash is characteristic of what congenital infection?
Rubella
Meningitis in neonates. Causes? Treatment?
Group B strep, E. coli, Listeria. Treat with gentamicin and ampicillin
Meningitis in infants. Causes? Treatment?
Pneumococcus, meningococcus, H. Influenzae. Treat with cefotaxime and vancomycin
What should always be done prior to LP?
Check for ↑ ICP; look for papilledema
CSF findings: Low glucose, PMN predominance
Bacterial meningitis
CSF findings: Normal glucose, lymphocytic predominance
Aseptic (viral) meningitis
CSF findings: Numerous RBCs in serial CSF samples
Subarachnoid hemorrhage (SAH)
CSF findings: gamma globulins
MS
Initially presents with a pruritic papule with regional lymphadenopathy and evolves into a black eschar after 7-10 days. Treatment?
Cutaneous anthrax. Treat with penicillin G or ciprofloxacin
Findings in 3° syphilis
Tabes dorsalis, general paresis, gummas, Argyll Robertson pupil, aortitis, aortic root aneurysms
Characteristics of 2° Lyme disease
Arthralgias, migratory polyarthropathies, Bell’s palsy, myocarditis
Cold agglutinins
Mycoplasma
A 24-year-old male presents with soft white plaques on his tongue and the back of his throat. Diagnosis? Workup? Treatment?
Candidal thrush. Workup should include an HIV test. Treat with nystatin oral suspension
Begin Pneumocystis carinii pneumonia (PCP) prophylaxis in an HIV-positive patient at what CD4 count? Mycobacterium avium-intracellulare (MAI) prophylaxis?
≤ 200 for PCP (with TMP-SMX); ≤ 50–100 for MAI (with clarithromycin/azithromycin)
Risk factors for pyelonephritis
Pregnancy, vesicoureteral reflux, anatomic anomalies, indwelling catheters, kidney stones
Neutropenic nadir postchemotherapy
7–10 days
Erythema migrans
Lesion of 1° Lyme disease
Classic physical findings for endocarditis
Fever, heart murmur, Osler’s nodes, splinter hemorrhages, Janeway lesions, Roth’s spots
Aplastic crisis in sickle cell disease
Parvovirus B19
Ring-enhancing brain lesion on CT with seizures
Taenia solium (cysticercosis)
Name the organism: Branching rods in oral infection
Actinomyces israelii
Name the organism: Painful chancroid
Haemophilus ducreyi
Name the organism: Dog or cat bite
Pasteurella multocida
Name the organism: Gardener
Sporothrix schenckii
Name the organism: Pregnant women with pets
Toxoplasma gondii
Name the organism: Meningitis in adults
Neisseria meningitidis
Name the organism: Meningitis in elderly
Streptococcus pneumoniae
Name the organism: Alcoholic with pneumonia
Klebsiella
Name the organism: “Currant jelly” sputum
Klebsiella
Name the organism: Infection in burn victims
Pseudomonas
Name the organism: Osteomyelitis from foot wound puncture
Pseudomonas
Name the organism: Osteomyelitis in a sickle cell patient
Salmonella
A 55-year-old man who is a smoker and a heavy drinker presents with a new cough and flulike symptoms. Gram stain shows no organisms; silver stain of sputum shows gram-negative rods. What is the diagnosis?
Legionella pneumonia
A middle-aged man presents with acute-onset monoarticular joint pain and bilateral Bell’s palsy. What is the likely diagnosis, and how did he get it? Treatment?
Lyme disease, Ixodes tick, doxycycline
A patient develops endocarditis three weeks after receiving a prosthetic heart valve a prosthetic heart valve. What organism is suspected?
S. aureus or S. Epidermidis
A patient presents with pain on passive movement, pallor, poikilothermia, paresthesias, paralysis, and pulselessness. Treatment?
All-compartment fasciotomy for suspected compartment syndrome
Back pain that is exacerbated by standing and walking and relieved with sitting and hyperflexion of the hips
Spinal stenosis
Joints in the hand affected in rheumatoid arthritis
MCP and PIP joints; DIP joints are spared
Joint pain and stiffness that worsen over the course of the day and are relieved by rest
Osteoarthritis
Genetic disorder associated with multiple fractures and commonly mistaken for child abuse
Osteogenesis imperfecta
Hip and back pain along with stiffness that improves with activity over the course of the day and worsens at rest. Diagnostic test?
Suspect ankylosing spondylitis. Check HLA-B27
Arthritis, conjunctivitis, and urethritis in young men. Associated organisms?
Reactive (Reiter’s) arthritis. Associated with Campylobacter, Shigella, Salmonella, Chlamydia, and Ureaplasma
A 55-year-old man has sudden, excruciating first MTP joint pain after a night of drinking red wine. Diagnosis, workup, and chronic treatment?
Gout. Needle-shaped, negatively birefringent crystals are seen on joint fluid aspirate. Chronic treatment with allopurinol or probenecid.
Rhomboid-shaped, positively birefringent crystals on joint fluid aspirate
Pseudogout
An elderly female presents with pain and stiffness of the shoulders and hips; she cannot lift her arms above her head. Labs show anemia and ↑ ESR
Polymyalgia rheumatica
An active 13-year-old boy has anterior knee pain. Diagnosis?
Osgood-Schlatter disease
Bone is fractured in fall on outstretched hand
Distal radius (Colles’ fracture)
Complication of scaphoid fracture
Avascular necrosis
Signs suggesting radial nerve damage with humeral fracture
Wrist drop, loss of thumb abduction
A young child presents with proximal muscle weakness, waddling gait, and pronounced calf muscles
Duchenne muscular dystrophy
A first-born female who was born in breech position is found to have asymmetric skin folds on her newborn exam. Diagnosis? Treatment?
Developmental dysplasia of the hip. If severe, consider a Pavlik harness to maintain abduction
An 11-year-old obese, African-American boy presents with sudden onset of limp. Diagnosis? Workup?
Slipped capital femoral epiphyses. AP and frog-leg lateral view
The most common 1° malignant tumor of bone
Multiple myeloma
Unilateral, severe periorbital headache with tearing and conjunctival erythema
Cluster headache
Prophylactic treatment for migraine
β-blockers, Ca2+ channel blockers, TCAs
The most common pituitary tumor. Treatment?
Prolactinoma. Dopamine agonists (e.g., bromocriptine)
A 55-year-old patient presents with acute “broken speech." What type of aphasia? What lobe and vascular distribution?
Broca’s aphasia. Frontal lobe, left MCA distribution
The most common cause of SAH
Trauma; the second most common is berry aneurysm
A crescent-shaped hyperdensity on CT that does not cross the midline
Subdural hematoma—bridging veins torn
A history significant for initial altered mental status with an intervening lucid interval. Diagnosis? Most likely etiology? Treatment?
Epidural hematoma. Middle meningeal artery. Neurosurgical evacuation
CSF findings with SAH
Elevated ICP, RBCs, xanthochromia
Albuminocytologic dissociation
Guillain-Barré (↑ protein in CSF with only a modest ↑ in cell count)
Cold water is flushed into a patient’s ear, and the fast phase of the nystagmus is toward the opposite side. Normal or pathological?
Normal
The most common 1° sources of metastases to the brain
Lung, breast, skin (melanoma), kidney, GI tract
May be seen in children who are accused of inattention in class and confused with ADHD
Absence seizures
The most frequent presentation of intracranial neoplasm
Headache
The most common cause of seizures in children (2–10 years)
Infection, febrile seizures, trauma, idiopathic
The most common cause of seizures in young adults (18–35 years)
Trauma, alcohol withdrawal, brain tumor
First-line medication for status epilepticus
IV benzodiazepine
Confusion, confabulation, ophthalmoplegia, ataxia
Wernicke’s encephalopathy due to a deficiency of thiamine
What % lesion is an indication for carotid endarterectomy?
Seventy percent if the stenosis is symptomatic
The most common causes of dementia
Alzheimer’s and multi-infarct
Combined UMN and LMN disorder
ALS
Rigidity and stiffness with resting tremor and masked facies
Parkinson’s disease
The mainstay of Parkinson’s therapy
Levodopa/carbidopa
Treatment for Guillain-Barré syndrome
IVIG or plasmapheresis
Rigidity and stiffness that progress to choreiform movements, accompanied by moodiness and altered behavior
Huntington’s disease
A six-year-old girl presents with a port-wine stain in the V2 distribution as well as with mental retardation, seizures, and leptomeningeal angioma
Sturge-Weber syndrome. Treat symptomatically. Possible focal cerebral resection of affected lobe
Café-au-lait spots on skin
Neurofibromatosis 1
Hyperphagia, hypersexuality, hyperorality, and hyperdocility
Klüver-Bucy syndrome (amygdala)
Administer to a symptomatic patient to diagnose myasthenia gravis
Edrophonium
1° causes of third-trimester bleeding
Placental abruption and placenta previa
Classic ultrasound and gross appearance of complete hydatidiform mole
Snowstorm on ultrasound. “Cluster-of-grapes” appearance on gross examination
Chromosomal pattern of a complete mole
46,XX
Molar pregnancy containing fetal tissue
Partial mole
Symptoms of placental abruption
Continuous, painful vaginal bleeding
Symptoms of placenta previa
Self-limited, painless vaginal bleeding
When should a vaginal exam be performed with suspected placenta previa?
Never
Antibiotics with teratogenic effects
Tetracycline, fluoroquinolones, aminoglycosides, sulfonamides
Shortest AP diameter of the pelvis
Obstetric conjugate: between the sacral promontory and the midpoint of the symphysis pubis
Medication given to accelerate fetal lung maturity
Betamethasone or dexamethasone × 48 hours
The most common cause of postpartum hemorrhage
Uterine atony
Treatment for postpartum hemorrhage
Uterine massage; if that fails, give oxytocin
Typical antibiotics for group B streptococcus (GBS) prophylaxis
IV penicillin or ampicillin
A patient fails to lactate after an emergency C-section with marked blood loss
Sheehan’s syndrome (postpartum pituitary necrosis)
Uterine bleeding at 18 weeks’ gestation; no products expelled; membranes ruptured; cervical os open
Inevitable abortion
Uterine bleeding at 18 weeks’ gestation; no products expelled; cervical os closed
Threatened abortion
Indications for medical treatment of ectopic pregnancy
Stable, unruptured ectopic pregnancy of < 3.5 cm at < 6 weeks’ gestation
Medical options for endometriosis
OCPs, danazol, GnRH agonists
Laparoscopic findings in endometriosis
“Chocolate cysts,” powder burns
The most common location for an ectopic pregnancy
Ampulla of the oviduct
How to diagnose and follow a leiomyoma
Ultrasound
Natural history of a leiomyoma
Regresses after menopause
A patient has ↑ vaginal discharge and petechial patches in the upper vagina and cervix
Trichomonas vaginitis
Treatment for bacterial vaginosis
Oral or topical metronidazole
The most common cause of bloody nipple discharge
Intraductal papilloma
Contraceptive methods that protect against PID
OCP and barrier contraception
Unopposed estrogen is contraindicated in which cancers?
Endometrial or estrogen receptor (+) breast cancer
A patient presents with recent PID with RUQ pain
Consider Fitz-Hugh–Curtis syndrome
Breast malignancy presenting as itching, burning, and erosion of the nipple
Paget’s disease
Annual screening for women with a strong family history of ovarian cancer
CA-125 and transvaginal ultrasound
A 50-year-old woman leaks urine when laughing or coughing. Nonsurgical options?
Kegel exercises, estrogen, pessaries for stress incontinence
A 30-year-old woman has unpredictable urine loss. Examination is normal. Medical options?
Anticholinergics (oxybutynin) or β-adrenergics (metaproterenol) for urge incontinence
Lab values suggestive of menopause
↑ serum FSH
The most common cause of female infertility
Endometriosis
Two consecutive findings of atypical squamous cells of undetermined significance (ASCUS) on Pap smear. Follow-up evaluation?
Colposcopy and endocervical curettage
Breast cancer type that ↑ the future risk of invasive carcinoma in both breasts
Lobular carcinoma in situ
Nontender abdominal mass associated with elevated VMA and HVA
Neuroblastoma
The most common type of tracheoesophageal fistula (TEF). Diagnosis?
Esophageal atresia with distal TEF (85%). Unable to pass NG tube
Not contraindications to vaccination
Mild illness and/or low-grade fever, current antibiotic therapy, and prematurity
Tests to rule out shaken baby syndrome
Ophthalmologic exam, CT, and MRI
A neonate has meconium ileus
CF or Hirschsprung’s disease
Bilious emesis within hours after the first feeding
Duodenal atresia
A two-month-old presents with nonbilious projectile emesis. What are the appropriate steps in management?
Correct metabolic abnormalities. Then correct pyloric stenosis with pyloromyotomy
The most common 1° immunodeficiency
Selective IgA deficiency
An infant has a high fever and onset of rash as fever breaks. What is he at risk for?
Febrile seizures (roseola infantum)
What is the immunodeficiency? A boy has chronic respiratory infections. Nitroblue tetrazolium test is (-)
Chronic granulomatous disease
What is the immunodeficiency? A child has eczema, thrombocytopenia, and high levels of IgA
Wiskott-Aldrich syndrome
What is the immunodeficiency? A four-month-old boy has life-threatening Pseudomonas infection
Bruton’s X-linked agammaglobulinemia
Acute-phase treatment for Kawasaki disease
High-dose aspirin for inflammation and fever; IVIG to prevent coronary artery aneurysms
Treatment for mild and severe unconjugated hyperbilirubinemia
Phototherapy (mild) or exchange transfusion (severe)
Sudden onset of mental status changes, emesis, and liver dysfunction after taking aspirin
Reye’s syndrome
A child has loss of red light reflex. Diagnosis?
Suspect retinoblastoma
Vaccinations at a six-month well-child visit
HBV, DTaP, Hib, IPV, PCV
Tanner stage 3 in a six-year-old female
Precocious puberty
Infection of small airways with epidemics in winter and spring
RSV bronchiolitis
Cause of neonatal RDS
Surfactant deficiency
A condition associated with red “currant-jelly” stools
Intussusception
A congenital heart disease that cause 2° hypertension
Coarctation of the aorta
First-line treatment for otitis media
Amoxicillin × 10 days
The most common pathogen causing croup
Parainfluenza virus type 1
A homeless child is small for his age and has peeling skin and a swollen belly
Kwashiorkor (protein malnutrition)
Defect in an X-linked syndrome with mental retardation, gout, self-mutilation, and choreoathetosis
Lesch-Nyhan syndrome (purine salvage problem with HGPRTase deficiency)
A newborn female has continuous “machinery murmur"
Patent ductus arteriosus (PDA)
First-line pharmacotherapy for depression
SSRIs
Antidepressants associated with hypertensive crisis
MAOIs
Galactorrhea, impotence, menstrual dysfunction, and ↓ libido
Patient on dopamine antagonist
A 17-year-old female has left arm paralysis after her boyfriend dies in a car crash. No medical cause is found
Conversion disorder
Name the defense mechanism: A mother who is angry at her husband yells at her child
Displacement
Name the defense mechanism: A pedophile enters a monastery
Reaction formation
Name the defense mechanism: A woman calmly describes a grisly murder
Isolation
Name the defense mechanism: A hospitalized 10-year-old begins to wet his bed
Regression
Life-threatening muscle rigidity, fever, and rhabdomyolysis
Neuroleptic malignant syndrome
Amenorrhea, bradycardia, and abnormal body image in a young female
Anorexia
A 35-year-old male has recurrent episodes of palpitations, diaphoresis, and fear of going crazy
Panic disorder
The most serious side effect of clozapine
Agranulocytosis
A 21-year-old male has three months of social withdrawal, worsening grades, flattened affect, and concrete thinking
Schizophreniform disorder (diagnosis of schizophrenia requires ≥ 6 months of symptoms)
Key side effects of atypical antipsychotics
Weight gain, type 2 DM, QT prolongation
A young weight lifter receives IV haloperidol and complains that his eyes are deviated sideways. Diagnosis? Treatment?
Acute dystonia (oculogyric crisis). Treat with benztropine or diphenhydramine
Psychiatric medication to avoid in patients with a history of alcohol withdrawal seizures
Neuroleptics
A 13-year-old male has a history of theft, vandalism, and violence toward family pets
Conduct disorder
A five-month-old girl has ↓ head growth, truncal dyscoordination, and ↓ social interaction
Rett’s disorder
A patient hasn’t slept for days, lost $20,000 gambling, is agitated, and has pressured speech. Diagnosis? Treatment?
Acute mania. Start a mood stabilizer (e.g., lithium)
After a minor fender bender, a man wears a neck brace and requests permanent disability
Malingering
A nurse presents with severe hypoglycemia; blood analysis reveals no elevation in C peptide
Factitious disorder (Munchausen syndrome)
A patient continues to use cocaine after being in jail, losing his job, and not paying child support
Substance abuse
A violent patient has vertical and horizontal nystagmus
Phencyclidine hydrochloride (PCP) intoxication
A woman who was abused as a child frequently feels outside of or detached from her body
Depersonalization disorder
A man has repeated, intense urges to rub his body against unsuspecting passengers on a bus
Frotteurism (a paraphilia)
A schizophrenic patient takes haloperidol for one year and develops uncontrollable tongue movements. Diagnosis? Treatment?
Tardive dyskinesia. ↓ or discontinue haloperidol and consider another antipsychotic (e.g., risperidone, clozapine)
A man unexpectedly flies across the country, takes a new name, and has no memory of his prior life
Dissociative fugue
Risk factors for DVT
Stasis, endothelial injury, and hypercoagulability (Virchow’s triad)
Criteria for exudative effusion
Pleural/serum protein > 0.5; pleural/serum LDH > 0.6
Causes of exudative effusion
Think of leaky capillaries. Malignancy, TB, bacterial or viral infection, pulmonary embolism with infarct, and pancreatitis
Causes of transudative effusion
Think of intact capillaries. CHF, liver or kidney disease, and protein-losing enteropathy
Normalizing PCO2 in a patient having an asthma exacerbation may indicate?
Fatigue and impending respiratory failure
Dyspnea, lateral hilar lymphodenopathy on CXR, noncaseating granulomas, increased ACE, and hypercalcemia
Sarcoidosis
PFT showing ↓ FEV1/FVC
Obstructive pulmonary disease (e.g., asthma)
PFT showing ↑ FEV1/FVC
Restrictive pulmonary disease
Honeycomb pattern on CXR. Diagnosis? Treatment?
Diffuse interstitial pulmonary fibrosis. Supportive care. Steroids may help
Treatment for SVC syndrome
Radiation
Treatment for mild, persistent asthma
Inhaled β-agonists and inhaled corticosteroids
Acid-base disorder in pulmonary embolism
Hypoxia and hypocarbia (respiratory alkalosis)
Non–small cell lung cancer (NSCLC) associated with hypercalcemia
Squamous cell carcinoma
Lung cancer associated with SIADH
Small cell lung cancer (SCLC)
Lung cancer highly related to cigarette exposure
SCLC
A tall white male presents with acute shortness of breath. Diagnosis? Treatment?
Spontaneous pneumothorax. Spontaneous regression. Supplemental O2 may be helpful
Treatment of tension pneumothorax
Immediate needle thoracostomy
Characteristics favoring carcinoma in an isolated pulmonary nodule
Age > 45–50 years; lesions new or larger in comparison to old films; absence of calcification or irregular calcification; size > 2 cm; irregular margins
Hypoxemia and pulmonary edema with normal pulmonary capillary wedge pressure
ARDS
↑ risk of what infection with silicosis?
Mycobacterium tuberculosis
Causes of hypoxemia
Right-to-left shunt, hypoventilation, low inspired O2 tension, diffusion defect, V/Q mismatch
Classic CXR findings for pulmonary edema
Cardiomegaly, prominent pulmonary vessels, Kerley B lines, “bat’s-wing” appearance of hilar shadows, and perivascular and peribronchial cuffing
Renal tubular acidosis (RTA) associated with abnormal H+ secretion and nephrolithiasis
Type I (distal) RTA
RTA associated with abnormal HCO3− and rickets
Type II (proximal) RTA
RTA associated with aldosterone defect
Type IV (distal) RTA
“Doughy skin"
Hypernatremia
Differential of hypervolemic hyponatremia
Cirrhosis, CHF, nephritic syndrome
Chvostek’s and Trousseau’s signs
Hypocalcemia
The most common causes of hypercalcemia
Malignancy and hyperparathyroidism
T-wave flattening and U waves
Hypokalemia
Peaked T waves and widened QRS
Hyperkalemia
First-line treatment for moderate hypercalcemia
IV hydration and loop diuretics (furosemide)
Type of ARF in a patient with FeNa < 1%
Prerenal
A 49-year-old male presents with acute-onset flank pain and hematuria
Nephrolithiasis
The most common type of nephrolithiasis
Calcium oxalate
A 20-year-old man presents with a palpable flank mass and hematuria. Ultrasound shows bilateral enlarged kidneys with cysts. Associated brain anomaly?
Cerebral berry aneurysms (autosomal-dominant PCKD)
Hematuria, hypertension, and oliguria
Nephritic syndrome
Proteinuria, hypoalbuminemia, hyperlipidemia, hyperlipiduria, edema
Nephrotic syndrome
The most common form of nephritic syndrome
Membranous glomerulonephritis
The most common form of glomerulonephritis
IgA nephropathy (Berger’s disease)
Glomerulonephritis with deafness
Alport’s syndrome
Glomerulonephritis with hemoptysis
Wegener’s granulomatosis and Goodpasture’s syndrome
Presence of red cell casts in urine sediment
Glomerulonephritis/nephritic syndrome
Eosinophils in urine sediment
Allergic interstitial nephritis
Waxy casts in urine sediment and Maltese crosses (seen with lipiduria)
Nephrotic syndrome
Drowsiness, asterixis, nausea, and a pericardial friction rub
Uremic syndrome seen in patients with renal failure
A 55-year-old man is diagnosed with prostate cancerTreatment options?
Wait, surgical resection, radiation and/or androgen suppression
Low urine specific gravity in the presence of high serum osmolality
DI
Treatment of SIADH?
Fluid restriction, demeclocycline
Hematuria, flank pain, and palpable flank mass
Renal cell carcinoma (RCC)
Testicular cancer associated with β-hCG, AFP
Choriocarcinoma
The most common type of testicular cancer
Seminoma—a type of germ cell tumor
The most common histology of bladder cancer
Transitional cell carcinoma
Complication of overly rapid correction of hyponatremia
Central pontine myelinolysis
Salicylate ingestion → in what type of acid-base disorder?
Anion gap acidosis and 1° respiratory alkalosis due to central respiratory stimulation
Acid-base disturbance commonly seen in pregnant women
Respiratory alkalosis
Three systemic diseases → nephrotic syndrome
DM, SLE, and amyloidosis
Elevated erythropoietin level, elevated hematocrit, and normal O2 saturation suggest?
RCC or other erythropoietin-producing tumor; evaluate with CT scan
A 55-year-old man presents with irritative and obstructive urinary symptoms. Treatment options?
Likely BPH. Options include no treatment, terazosin, finasteride, or surgical intervention (TURP)
Class of drugs that may cause syndrome of muscle rigidity, hyperthermia, autonomic instability, and extrapyramidal symptoms
Antipsychotics (neuroleptic malignant syndrome)
Side effects of corticosteroids
Acute mania, immunosuppression, thin skin, osteoporosis, easy bruising, myopathies
Treatment for DTs
Benzodiazepines
Treatment for acetaminophen overdose
N-acetylcysteine
Treatment for opioid overdose
Naloxone
Treatment for benzodiazepine overdose
Flumazenil
Treatment for neuroleptic malignant syndrome
Dantrolene or bromocriptine
Treatment for malignant hypertension
Nitroprusside
Treatment of AF
Rate control, rhythm conversion, and anticoagulation
Treatment of supraventricular tachycardia (SVT)
If stable, rate control with carotid massage or other vagal stimulation; if unsuccessful, consider adenosine
Causes of drug-induced SLE
INH, penicillamine, hydralazine, procainamide, chlorpromazine, methyldopa, quinidine
Macrocytic, megaloblastic anemia with neurologic symptoms
B12 deficiency
Macrocytic, megaloblastic anemia without neurologic symptoms
Folate deficiency
A burn patient presents with cherry-red flushed skin and coma. SaO2 is normal, but carboxyhemoglobin is elevated. Treatment?
Treat CO poisoning with 100% O2 or with hyperbaric O2 if severe poisoning or pregnant
Blood in the urethral meatus or high-riding prostate
Bladder rupture or urethral injury
Test to rule out urethral injury
Retrograde cystourethrogram
Radiographic evidence of aortic disruption or dissection
Widened mediastinum (> 8 cm), loss of aortic knob, pleural cap, tracheal deviation to the right, depression of left main stem bronchus
Radiographic indications for surgery in patients with acute abdomen
Free air under the diaphragm, extravasation of contrast, severe bowel distention, space-occupying lesion (CT), mesenteric occlusion (angiography)
The most common organism in burn-related infections
Pseudomonas
Method of calculating fluid repletion in burn patients
Parkland formula
Acceptable urine output in a trauma patient
50 cc/hour
Acceptable urine output in a stable patient
30 cc/hour
Cannon “a” waves
Third-degree heart block
Signs of neurogenic shock
Hypotension and bradycardia
Signs of ↑ ICP (Cushing’s triad)
Hypertension, bradycardia, and abnormal respirations
↓ CO, ↓ pulmonary capillary wedge pressure (PCWP), ↑ peripheral vascular resistance (PVR)
Hypovolemic shock
↓ CO, ↑ PCWP, ↑ PVR
Cardiogenic shock
↑ CO, ↓ PCWP, ↓ PVR
Septic or anaphylactic shock
Treatment of septic shock
Fluids and antibiotics
Treatment of cardiogenic shock
Identify cause; pressors (e.g., dopamine)
Treatment of hypovolemic shock
Identify cause; fluid and blood repletion
Treatment of anaphylactic shock
Diphenhydramine or epinephrine 1:1000
Supportive treatment for ARDS
Continuous positive airway pressure
Signs of air embolism
A patient with chest trauma who was previously stable suddenly dies
Trauma series
AP chest, AP/lateral C-spine, AP pelvis
What vitamin deficiency? Night blindness, dry skin
Vitamin A
What vitamin deficiency? Beriberi (polyneuritis, dilated cardiomyopathy, high-output CHF, edema), Wernicke-Korsakoff syndrome
Vitamin B1 (thiamine)
What vitamin deficiency? Angular stomatitis, cheilosis, corneal vascularization
Vitamin B2 (riboflavin)
What vitamin deficiency? Pellagra (diarrhea, dermatitis, dementia)
Vitamin B3 (niacin)
What vitamin deficiency? Dermatitis, enteritis, alopecia, adrenal insufficiency
Vitamin B5 (pantothenate)
What vitamin deficiency? Convulsions, hyperirritability; required during administration of INH
Vitamin B6 (pyridoxine)
What vitamin deficiency? Macrocytic, megaloblastic anemia; neurologic symptoms (e.g., optic neuropathy, subacute combined degeneration, paresthesias); glossitis
Vitamin B12 (cobalamin)
What vitamin deficiency? Scurvy (e.g., swollen gums, bruising, anemia, poor wound healing)
Vitamin C
What vitamin deficiency? Rickets in children (bending bones), osteomalacia in adults (soft bones), hypocalcemic tetany
Vitamin D
What vitamin deficiency? ↑ fragility of RBCs
Vitamin E
What vitamin deficiency? Neonatal hemorrhage; ↑ PT and aPTT, normal BT
Vitamin K
What vitamin deficiency? Dermatitis, enteritis. Can be caused by ingestion of raw eggs or antibiotic use
Biotin
What vitamin deficiency? The most common vitamin deficiency in the United States. Sprue; macrocytic, megaloblastic anemia without neurologic symptoms
Folic acid
What vitamin deficiency? Weakness, muscle cramps, exacerbation of hypocalcemic tetany, CNS hyperirritability → tremors, choreoathetoid movement
Magnesium
What vitamin deficiency? Keshan disease (cardiomyopathy)
Selenium