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52 Cards in this Set
- Front
- Back
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Tx for prolactinoma?
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Bromocryptine
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What is Bromocriptine?
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dopamine analogue
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What does dopamine do to prolactin?
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inhibits prolactin
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What inhibits prolactin?
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dopamine
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What drugs enhance ADH?
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chlorpropamide
cyclophosphamide morphine |
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What happens in SiADH?
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you secrete too much ADH
so you retain water -Si (yes) to ADH lot's of ADH |
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What happens in DI?
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- you pee a lot
- just like in diabetes (polyuria) |
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Tx of SiADH?
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demeclocycline
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Why does it make sense to Tx SiADH w/ demeclocycline?
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Because it causes DI which is the opposite of SiADH
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What is the best Tx of SiADH?
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Restrict Water
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MCC death for acromegaly patients? (GH excess)
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Heart Failure
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What causes all the changes in acromegaly?
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IGF-1
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Where is IGF-1 secreted?
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Liver
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How do bones grow in acromegaly?
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lateral growth (not linear)
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What is the MC lab result in patients w/ GH excess?
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hyperglycemia
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What are other causes of prolactinemia besides prolactinoma?
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1) O.C.'s
2) hydralazine 3) H2 Blockers 4) 1ry hypothyroidism |
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Is it a normal finding to see galactorrhea in a newborn girl?
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Yes, due to maternal estrogen
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What cancer is associated with SiADH?
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Small Cell CA of the lung
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How is the Urinary OSM in SiADH?
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increased
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How is the plasma OSM in SiADH?
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decreased
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What drug causes aplastic anemia?
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Chloramphenicol
Indomethacine phenylbutazone thyroid related drug |
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What diseases infection causes aplastic anemia?
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Hepatitis C
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Aplasia of RBC, what virus?
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Parvovirus
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What other cause of aplastic anemia?
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Radiation
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What drug is used to decrease vaso-oclussive crisis?
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Hydroxy urea
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MC organism to cause osteomyeltitis in Sickle Cell?
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Salmonella
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G6PD is what inheritance?
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X-linked recessive
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Lesch-Nyhann Sx is what inheritance?
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X-linked recessive
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What two drugs used for HT for pregnancy?
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1) Hydralazine, Methyl-Dopa
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Hydralazine causes?
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SLE-lupus like
Drug-induced lupus |
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Patient on Penicillin and develops rash, HS type?
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Hyerpsensitivity Type I
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Pat. on Penicillin and develops hemolytic anemia, HS type?
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Hypersensitivity Type II
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What is the MCC of Autoimmune Hemolytic Anemia?
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Lupus
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Family w/ Autoimmune Dz: Best Screening Test
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HLA Relationships
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What 2 drugs induce hemolysis w/ G6PD?
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1) Primaquine
2) Dapsone |
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What is the tx for Lead poisoning?
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Succimer
EDTA Dimercarprol |
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What enzymes are irreversibly inhibited by Lead?
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1) Ferrochelatase
2) ALA dehydrase |
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What accumulates in Lead Poisoning?
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1) Protoporphyrin IX
2) dela-ALA (acid) |
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What are the three causes of sideroblastic anemia?
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1) Alcoholism (MC)
2) Pyridoxine (B6)def. 3) Lead (Pb) poisoning |
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What enzyme does vit. B6 deficiency inhibit?
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ALA synthase
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What are the physical diagnostic findings of Lead poisoning?
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Abdominal Pain Colic
Diarrhea Encephalopathy (accumul. of toxic ALA acid) Cerebral Edema Growth Retardation (lead deposits in epiphysis) demyelination (ALA Acid damage) Peripheral Neuropathy foot drop, wrist drop, claw hand Lead line on gums |
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What does Lead (Pb) cause at Renal level?
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nephrotoxic to proximal tubules
Fanconi Syndrome (Acidosis, loss of HCO3) |
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Why does Lead cause gout?
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decreases renal excretionn of uric acid
because of renal toxicity and increase in ALA acid filtration |
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What type of anemia does Pb cause?
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microcytic anemia
Causes Iron Overload increased serum Iron,% Saturation, ferritin Decreased TIBC |
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Tx for Lead (Pb) poisoning?
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Succimer
Sucks the Lead away from your body! |
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What drug is used to decrease vaso-oclussive crisis?
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Hydroxy urea
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What are two X-linked recessive?
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Lesch-Nyhan Sx
G6PD |
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What is characteristic of Lesch-Nyhan Sx?
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purine metabolism
metally retarded self mutilation increase in uric acid HGPRT deficient |
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What is the co-factor vitamine in G6PD?
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B2 Riboflavin
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What co-factor/trace element needed in G6PD?
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Selenium (Se)
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What 2 drugs induce hemolysis w/ G6PD?
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1) Primaquine
2) Dapsone |
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What is the MCC of Autoimmune Hemolytic Anemia?
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Warm IgG Lupus
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