Usmle Step 1 Pharmacy Drug Rxns

Front 1

Coronary Vasospasm

Back 1

1. COCAINE
2. SUMATRIPTAN
3. ERGOT

Front 2

Cutaneous Flushing

Back 2

1. Vancomycin
2. Adenosine
3. Niacin
4. Calcium Channel Blockers

Hint 2

VANC

Front 3

Dilated Cardiomyopathy

Back 3

1. Doxorubicin
2. Daunorubicin

Front 4

Torsades de Pointes

Back 4

1. Sotalol Class III
2. Quinidine Class IA
3. Macrolide Anitbiotics
4. Antipsychotics
5. TCA's: [ssri nsri]

Front 5

Adrenocortical Insufficiency

Back 5

HPA suppression secondary to glucocorticoid withdrawal

Front 6

Hot Flashes

Back 6

1. Tamoxifen
2. Clomiphene: [induce ovulation]

Front 7

Hyperglycemia

Back 7

1. Tacrolimus
2. Protease Inhibitors: [Antiviral for HIV and Hep C]
3. Niacin
4. HCTZ
5. Beta Blockers
6. Corticosteroids

Hint 7

Taking Pills Necessitates Having Blood Checks

Front 8

Hypothyroidism

Back 8

1. Lithium
2. amioderone: [anti arrhythmic]
3. sulfonamides

Front 9

Acute Cholestatic Hepatitis, Jaundice

Back 9

Erythromycin: [Macrolide Antibiotic]

Front 10

Diarrhea

Back 10

1. Metformin
2. Erythromycin
3. Colchicine: [Gout-binds microtubules]
4. Orlistat: [Obesity-Pancreatic Lipase Inhibitor]
5. Acarbose: [DM II-alpha glucosidase inhibitor]

Hint 10

Might Excite Colon On Accident

Front 11

Focal To Massive Hepatic Necrosis

Back 11

1. Halothane: [Inhaled General Anesthetic]
2. Amanita Phalloides: [death cap mushroom]
3. Valproic Acid: [General Myoclonic seizure]
4. Acetaminophen

Hint 11

Liver HAVAc

Front 12

Hepatitis

Back 12

INH

Front 13

Pancreatitis

Back 13

1. Didanosine: [HIV-reverse transcriptase inhibitor]
2. Cortiscosteroids
3. Alcahol
4. Valproic Acid: [General Myoclonic Siezure]
5. Azathioprine: [Organ Transplant mercaptopurine pro-drug]
6. Diuretics: [Furosimide, HCTZ]

Hint 13

Drugs Causing A Violent Abdominal Distress

Front 14

Pseudomembranous Colitis

Back 14

1. Clindamycin
2. Ampicillin
3. Cephalosporins

Front 15

Agranulocytosis

Back 15

1. Dapsone: [Antibacterial]
2. Clozapine: [Schizophrenia]
3. Carbamazepine: [Partial Siezures+ Tonic Clonic]
4. Colchicine: [Gout, Med Fever- binds microtubules]
5. Methimazole: [Hypothyroid Graves]
6. Propylthiouricil: [Hypothyroid Graves]

Hint 15

Drugs CCCrush Meylobalsts and Premyelocites

Presents: Low White Count

Front 16

Aplastic Anemia

Back 16

1. Carbamazepine: [Partial siezure + Tonic Clonic]
2. Methimazole: [Hyperthyroid Graves]
3. NSAIDS
4. Benzene
5. Chloramphenicol: [Antibacterial gram- gram+ anaerobic]
6. Propylthiouracil: [Hypothyroid Graves]

Hint 16

Can't Make New Blood Cells Properly

Presents: Deficiency in all three blood cell types: Red(anemia), Platelets(Thrombocytopenia), White(Leukopenia)

Front 17

Gray Baby Syndrome

Back 17

Chloramphenicol: [Antibacterial]

Front 18

Hemolysis in G6PD deficiency

Back 18

1. INH
2. Sulfonamides
3. Dapsone: [Antibacerial]
4. Primaquine: [Malaria, Pneumocystic Pneumonia]
5. Aspirin
6. Ibuprofen
7. Nitrofurantoin: [Antibacterial]

Hint 18

Hemolysis IS D PAIN

Non-Autoimmune Hemolytic Anemia during
Increased oxidative stress[decreased glutathione] X-Linked recessive

Front 19

Megalobastic Anemia

Back 19

1. Phenytoin: [ General Tonic Clonic Seizure
2. Methotrexate: [Cancer Rheumatoid Artheritis]
3. Sulfa Drugs

Hint 19

Having a blast with PMS

Front 20

Thrombocytopenia

Back 20

1. Heparin
2. Cimetidine: [Peptic Ulcer Histamine H2 receptor antagonist]

Front 21

Thrombotic Complications

Back 21

OCP's e.g. Estrogens

Front 22

Fat Redistribution

Back 22

1. Protease Inhibitors: [HIV Hep C Antiviral]
2. Glucocorticoids: [Cushings]

Hint 22

Fat PiG

Front 23

Gingival Hyperplasia

Back 23

1. Phenytoin: [General Tonic Clonic Siezure]
2. Verapamil: [Calcium Channel Blocker]
3. Cyclopsorine: [Organ transplant immunosepressant]
4. Nifedipine: [Calcium Channel Blocker]

Front 24

Hyperuricemia (gout)

Back 24

1. Pyrazinamide: [TB]
2. Thiazides
3. Furosemide
4. Niacin
5. Cyclosporine: [Organ transplant Immunosuppresant]

Hint 24

Painful Tophi and Feet Need Care

Front 25

Myopathy

Back 25

1. Fibrates
2. Niacin
3. Colchicine
4. Hydroxychloroquine
5. Inteferon Alpha
6. Penicillamine
7. Satins
8. Glucocorticoids

Hint 25

FINCH PeGS

Front 26

Osteoperosis

Back 26

1. Corticosteroids
2. Heparin

Front 27

Photosensitivity

Back 27

1. Sulfonamides
2. Amioderone: [Arrhythmias]
3. Tetracyclines: [Antibacterial]
4. 5-FU: [Inhibit thymidilate synthase]

Hint 27

SAT For Photo

Front 28

Direct Coombs- Positive Hemolytic Anemia

Back 28

1. Methyldopa
2. Penicillin

Hint 28

HAMP
Autoimmune: Anitbodies Against Red Blood Cells Lyse them

Front 29

Rash (Stevens-Johnson Syndrome)

Back 29

1. Anti-epileptic (ethosuximide, carbamazepine, lamotrigine, Phenytoin, Phenobarbital)
2. Allopurinol
3. Sulfa Drugs
4. Penicillin

Hint 29

Steven Johnson has EPILEPTIC ALLergy to SULFA DRUGS and PENICILLIN

Milder form of Toxic Epidermal Necrolysis epidermis seperates from dermis. Weave-basket patttern on histology

Front 30

SLE-like syndrome

Back 30

1. Sulfa Drugs
2. Haydralazine: [HTN/HF vasodilator]
3. INH
4. Procainamide: [Ia anti-arrhythmic]
5. Phenytoin
6. Etanercept: [autoimmune diseases TNF Inhibitor]

Hint 30

Having Lupus is "SHIPP-E"

Front 31

Teeth Discoloration

Back 31

Tetracylcines

Front 32

Tendonitis, Tendon Rupture, and Cartilage Damage

Back 32

1. Fluoroquinolones: [antibiotic]

Front 33

Cinchonism

Back 33

1. Quinidine: [arrythmia/malaria]
2. Quinine: [Malaria]

Hint 33

skin rashes, deafness (reversible), somnolence, diminished visual acuity or blindness, anaphylactic shock, cardiotoxicity

Front 34

Parkinson-like syndrome

Back 34

1. Antypsychotics
2. Reserpine
3. Metoclopramide

Hint 34

Cogwheel rigidity of ARM

Front 35

Siezures

Back 35

1. INH (vitamin B6 deficinecy)
2. Bupropion: [Antidepressant/Smoking aid]
3. Imipenem/Cilastatin: [Beta Lactam Antibiotic]
4. Tramadol: [Analgesic Opiod]
5. Enflurane: [Anesthesia]
6. Metoclopramide: [GERD antiemetic]

Hint 35

with siezures, I BITE My tongue

Front 36

Tardive Dyskanesia

Back 36

1. Antipsychotics
2. Metoclopramide

Front 37

Diabetes Insipidus

Back 37

1. Lithium
2. Demeclyocycline

Front 38

Fanconi Syndrome

Back 38

1. Expired Tetraclycline

Hint 38

Disease of the proximal renal tubules of the kidney where glucose, amino acids, uric acid, phosphate and bicarbonate pass into urine, instead of being reabsorbed. Drug induced or Genetic

Front 39

Hemorrhagic cystitis

Back 39

1. Cyclophosphamide: [Cancer Autoimmune]
2. Ifosfomide: [Sex Cancers]

Hint 39

Prevent by co-administering with mensa

lower urinary tract symptoms that include dysuria, hematuria, and hemorrhage originating from Urinary Bladder

Front 40

Interstitial Nephritis

Back 40

1. Methicillin
2. NSAIDS
3. Furosamide

Front 41

SIADH

Back 41

1. Carbamazepine
2. Cyclophosphamide: [Cancer Anutoimmune]
3. SSRI's

Hint 41

Can't Concentrate Serum Sodium

Front 42

Dry Cough

Back 42

1. ACE Inhibitors

Front 43

Pulmonary Fibrosis

Back 43

1. Bleomycin
2. Amioderone: [Annti-Arrythmic]
3. Busulfan: [Leukemia]
4. Methotrexate: [Cancer Autoimmune]

Hint 43

Breathing Air Badly from Medications

Front 44

Toxin: Acetominophen

Back 44

Antidote: N-acetylcystiene (replenishes glutathione)

Hint 44

Front 45

Toxin: AChE inhibitors, Organophosphates

Back 45

Antidote: Atropine followed by pralidoxime

Hint 45

1. Atropine blocks achetylcholine action at nerve junction but is not an actual antidote.

2. AChE normally binds ACh at 2 sites. The toxin binds at only 1 of these sites and inhibits the enzyme. Praladoxine binds at the other end, attaches to the toxin, changes its conformation, and then toxin-antidote both leave the enzymatic site together.

Front 46

Toxin: Amphetamines (basic)

Back 46

Antidote: NH4Cl (acidify urine)

Front 47

Toxin: Antimuscarinic, Anticholinergic Agents

i.e Atropine, Scopalamine, Hyoscyamine

Back 47

Antidote: Physostigmine Salicylate, Control Hypothermia

Hint 47

Acetylcholinesterase Inhibitor indirectly increases the amount of acetylcholine in cleft.

Front 48

Toxin: Benzodiazepines

Back 48

Antidote: Flumazenil

Hint 48

Most patients with pure benzodiazepine overdose will usually only exhibit these mild CNS symptoms

Can reverse CNS depression but not Respiratory depression. Only indicated in 10% of cases becasue of side effects

Front 49

Toxin: B-Blockers

Back 49

Antidote: Glucagon

Front 50

Toxin: Carbon Monoxide

Back 50

Antidote: 100% O2, Hyperbaric O2

Front 51

Toxin: Copper, Arsenic, Gold

Back 51

Antidote: Penicillamine

Hint 51

Chelating Agent: Binds to copper, arsenic and gold and eliminates it through urine.

Front 52

Toxin: Cyanide

Back 52

Antidote: Nitrite+thiosulfate, Hydroxocobalamin

Hint 52

1. Hydroxocobalamin reacts with cyanide to form cyanocobalamin, which can be safely eliminated by the kidneys.
2. The nitrites oxidize hemoglobin to methemoglobin, which competes with cytochrome oxidase for cyanide ion. Cyanmethemoglobin is formed and the cytochrome oxidase enzyme is restored. The major mechanism to remove the cyanide from the body is by enzymatic conversion to thiocyanate by the mitochondrial enzyme rhodanese. Thiocyanate is a relatively non-toxic molecule and is excreted by the kidneys

Front 53

Toxin: Digitalis

Back 53

Antidote: Anti-Dig Fab Fragments

Hint 53

Front 54

Toxin: Heparin

Back 54

Antidote: Protamine sulfate

Front 55

Toxin: Iron

Back 55

Antidote: Deferoxamine, deferasirox

Front 56

Toxin: Lead

Back 56

Antidote: EDTA, dimercaprol, succimer, penicillamine

Front 57

Toxin: Mercury, Arsenic, Gold

Back 57

Antidote: Dimercaprol (BAL), succimer

Front 58

Toxin: Methanol, Ethylene Glycol

Back 58

Antidote: Fomepizole > Alcahol, Dialysis

Front 59

Toxin: Methemoglobin

Back 59

Antidote: Methylene Blue, Vitamin C

Front 60

Toxin: Opioids

Back 60

Antidote: Naloxone

Front 61

Toxin: Salicylates

Back 61

Antidote: NaHCO3 (alkalinize urine), Dialysis

Front 62

Toxin: TCA's

Back 62

Antidote: NaHCO3 (plasma alkalinization)

Front 63

Toxin: tPA, Streptokinase, Urokinase

Back 63

Antidote: Aminocaproic Acid

Front 64

Toxin: Warfarin

Back 64

Anitdote: Vitamin K, Plasma (if active bleeding)

Front 65

Anti-muscarinic

Back 65

1. Atropine
2. TCA
3. Anit-psychotics
4. H1 Blockers

Front 66

Disulfiram Like Reaction

Back 66

1. Metronidazole
2. Cephalosporins
3. Griseofulvin
4. Procarbazine
5. 1st Generation Sulfonyureas

Front 67

Nephrotoxicity/Ototoxicity

Back 67

1. Vancomycin
2. Aminoglycosides
3. Furosimide-Loop Diuretics
4. Cisplatin

Front 68

Cytochrome p450 Inducers +

Back 68

1. Chronic Alcohol Use
2. Modafinil
3. St. Johns Wart
4. Phenytoin
5. Phenobarbitol
6. Nevirapine NNRTI
7. Rifampin
8. Grisofulvan
9. Carbamazipine

Hint 68

Chronic Alcaholic Mona Steals Phen-Phen and Never Refuses Greasy Carbs

Front 69

Substrates

Back 69

1. Anti-epileptics
2. Anti depressants
3. Antipsychotics
4. Anesthetics
5. Theophyline
6. Warfarin
7. Statins
8. OCPs

Hint 69

Always Always Always Always Think When Starting Others

Front 70

Cytochrome P450 Inhibitors -

Back 70

1. Acute Alcahol abuse
2. Gemfibrozil
3. Ciprofloxacin
4. Isoniazid
5. Grapefruit Juice
6. Quinidine
7. Amioderone
8. Ketoconazole
9. Macrolides
10. Sulfonamides
11. Cimetidine
12. Ritanovir

Hint 70

A Cute Gentleman Cippied Iced Grapefruit Juice Quickly And Kept Munching on Soft Cinnamon Rolls

Front 71

Sulfa Drugs

Back 71

1. Probenecid
2. Furosimide
3. Acetazolamide
4. Celecoxib
5. Thiazides
6. Sulfonamide Antibiotics
7. Sulfsalazine
8. Sulfonylureas

Hint 71

Popular FACTSSS