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220 Cards in this Set
- Front
- Back
Lactose formers
|
“CEEK”
Citrobacter Enterobacter E.Coli (K1 capsule most important) Klebsiella |
|
Non lactose formers
|
SHYPS”
Shigella Yersinia enterolytica (AKA Pestis) Proteus Salmonella |
|
May lack color
|
“These rascals may microscopically lack color”:
Treponema Mycobacterium Mycoplasma Legionella Chlamydia |
|
increased cAMP
|
“CAPE”
Cholera Anthracis (Poly D glutamate capsule) Pertusis (via Gi) E.coli (LT enterotoxin) |
|
Have Capsules [ie… are Quellung Reaction (+)]
|
“Some killers have pretty nice capsules”
Strep. Pneumoniae Klebsiella HiB Pseudamona Aeroginosa Neisseria meningitis Cryptococcus neoformans (only encapsulated fungal pathogen) |
|
Dimorphic Fungi
|
"Can Also Have Both Shapes”
Cocciodes Aspergillus Histolpasma Blastomyces Sprothrix schenkii |
|
Have Beta Prophage
|
OBED
O = Salmonella B = Botulinum E = Erythrogenic strep D = Diptheria |
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Spore Forming Bacteria
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Bacilus & Clostridium (have calcium di-picolinate)
|
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IgA Proteases
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Neisseria, Haemophilus, S. pneumoniae
|
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Widal Test
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Salmonella (Salmonella begins in the ileocecal region) agglutination indicates Abs to O, H, Vi Salmunella Ags
|
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Wayson’s Stain
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Yersinia
|
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Pneumonic Plaque Transmission
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Person to person cf w/ Bubonic plaque that was via infected flea
|
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Splenectomy
|
Predisposes to septicemia
|
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Invasins
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Yersinia pseudotuberculosis
|
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Fusiform
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Vincent’s trench mouth
|
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Strep viridans
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Dextran mediated adherence
alpha hemolytic, no capsule, optochin resistant, not bile soluble S. mutans: dental caries S. sanguis: subacute endocarditis |
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Obligate Anaerobes
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Clostridium, Actinomyces, Bacteroides
|
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Obligate Aerobes
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Pseudomonas & Mycobacterium
|
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Staph aureus
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A Protein, Catalase +/ Coagulase +
|
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Spirochetes
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Treponema, Borrelia, Leptospira
|
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Non Motile Gram (+) Rods
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Corenybacterium D & Nocardia
|
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Acid Fast Organisms
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Mycobacterium; Cryptosporidium; Nocardia (partially); Legionella micdadei; Isospora
|
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Pigment Producing Bacteria
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Serratia – red (can cause pseudohemoptysis)
Pseudomonas A – piocyanin blue/green Staph Aureus – yellow – Protein A Mycobacteria – photo/scoto chromogenic – caritinoid – yellow/orange Corneybacterium D – black/gray – pseudomembrane plaque in throat Bacteroides (Porphyromonas) melaninogenicus – black (heme) E. coli – irredescent green sheen |
|
Bacterial Morphology
|
Pneumococci – lancet shaped diplococci
Neisseria – kidney bean shaped diplococci Camphylobacter – gulls’ wings/comas Vibrio Cholera – coma shaped Corneybacterium D – club shaped (nonmotile, G+Rod) Yersinia – safety pin seen in Wayson’s stain |
|
Inclusion Bodies
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Rabies – Negri bodies – intracytoplasmic
Pox virus – Guarnieri – intracytoplasmic & acidophilic CMV – Owl’s eyes – intracytoplasmic & intranuclear HSV – Cowdry bodies – intranuclear |
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Schistosoma Japonicum Monsoni
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Intestinal – contact w/ bad water
|
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Schistosoma Haematolium
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Vesicular – contact w/ bad water
|
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Non Human Schistosom
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Swimmer’s itch – contact w/ bad water
|
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Clonorchichis
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Chinese liver fluke – eating raw fish. Txt: Praziquantel
|
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Fasciola Hepatica
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Sheep – eating raw fish. Txt: Praziquantel
|
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Fasciola Biski
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Giant intestinal flukes – eating raw fish. Txt: Praziquantel
|
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Paragonimus Westermani
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Lung fluke – eating raw fish. Txt: Praziquantel
|
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Oxidase (+)
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Neiserria and most Gram (-)s
|
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Micro Aerophilic
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Camphylobacter & Helicobacter
|
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Urease (+)
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All Proteus – can cause Staghorn/Struvite calculi (NH4- Mg2- stones): alkaline urine
Ureaplasma Campylobacter pylori (Helicobacter) Cryptococcus Nocardia |
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Coagulase (+)
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Staph A & Yersenia pestis
|
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Obligate Intracellular Bacteria
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Treponema palidum & Pneumocystis Carinii (cannot be cultured on inert media but can be found extra cellularly in the body)
|
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Haemophilus Factors
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Haemophilus Factors
|
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All cocci are
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Gram (+) except for Neisseria & Moraxella
|
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“Eaton Fried Eggs”
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Mycoplasma pneumoniae has fried egg colonies on Eaton agar (needs cholesterol)
|
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Mycoplasma
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No cell wall. Membrane has cholesterol. Smallest living bacteria.
P1 protein inhs ciliary action Fried egg colonies Atypical pneumonia – young adults |
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Sabrands
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Fungal media
|
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Malassazia furfur
|
Spaghetti & meat ball
|
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Measles’ 3C’s
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Cough – Coryza – Conjunctivitis. Can also have photophobia
May lead to subacute Sclerosing Panencephalitis |
|
Non Motile Bacilli & Clostridium
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B. Anthracis & C. Perfringens
|
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Bloody diarrhea agents
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EIEC – EHEC – Shigella - Yersenia enterocolitica – Entaemeba histolytica – Salmonella – Campylobacter jejuni
|
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YW-135CA
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N. meningitidis vaccine capsualr polysaccharide strains
|
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Indian Ink
|
Cryptococcus neoformans
|
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Naegleria causes
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Colonization in the nasal passages after swimming
|
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Need Cysteine for growth
|
“Ella likes cysteine”:
Francisella Brucella Legionella Pasturella |
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Osteoporosis
|
465. Heparin
466. Corticosteroids |
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Protozoa
|
89. Plasmodium; Toxoplasma ghondi; Babesin; Leishmania; Trypanosoma Cruzi
|
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Obligate Non Intracellular Parasites
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90. Treponema palidum & Pneumocystis Carinii (cannot be cultured on inert media but can be found extra cellularly in the body)
|
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Endotoxins, G(+) or G(-)
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Gram (-): N. meningitidis
|
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Ecthyma Gangrenosum, seen w/
|
Pseudomonas aeroginosa. Target shaped skin lesions w/ a black center and red ring surrounding the lesion
|
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Endospores G(+)
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Gram (+): Bacillus & Clostridium – made up of dipicolinate & Keratin
|
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Multi Brain Abscess
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Nocardia
|
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Single Brain Abscess
|
Actinomyces israelli
|
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↑ risk for Strep pneum Infection
|
Asplenic; Sickle cell anemia; immunocompromising illness
|
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α Hemolysis/Optochin Sensitive
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Strep. Pneumoniae
|
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α Hemolysis/Optochin Resistant
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Strep. Viridans (Subacute Endocarditis)
|
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Staph. Saprophyticus
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Novobiocin Resistant (UTIs)
|
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Staph. Epidermidis
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Novobiocin sensitive (Endocarditis in IVDUs)
|
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β Hemolysis/Bacitracin Sensitive
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Strep. Pyogenes (pharyngitis; Scarlet fever; cellulitis; impetigo; Rheumatic fever))
Hyaluronic capsule; non-motile; M proteins; Endotoxin A |
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β Hemolysis/Bacitracin Resistant
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Strep. Agalactiae (Diabetes predisposes to infection)
|
|
EFII Ribosylation
|
Diphtheria toxin & Pseudomonas exotoxon A
|
|
Bacillus Anthracis: 3 toxins
(work via adenylate cyclase) |
Protective Antigen (PA)
Lethal Factor = toxic to macrophages Edema Factor = ↑ cAMP |
|
Woolsorter’s Disease
|
Bacillus anthracis. DOC: Penicillin
|
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Grows in Rice
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Bacillus Cereus
|
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Clostridium Perfringens
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Double Zone β Hemolysis (test)
Lecithinase: α toxin = lyses RBCs 80% of gas gangrene (myonecrosis) cases |
|
Clostridium Difficile
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2 Toxins: Enterotoxin (Exotoxin A) & Cytotoxin (Exotoxin B)
Pseudomembranous colitis (can be precipitated by clindamycin/ampicillin) |
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Spastic Paralysis toxin
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Clostridium Tetani toxin
|
|
Clostridium Botulinum
|
Bad canned foods have neurotoxin = flaccid paralysis (block Ach release)
|
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Infant Botulinum
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Floppy Baby Syndrome. Pre formed toxin in honey
|
|
Thayer Martin Agar
|
Neisseria ID
|
|
DOC for N. gonorrhoeae
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Ceftriazone
|
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K1 E. Coli Capsular Ag
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Related w/ neonateal meningitis
|
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The A’s of Klebsiella
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Alcoholics
Aspiration pneumonia Abscesses in the lungs |
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Rice H2O Diarrhea
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Vibrio Cholera: metabolic acidosis
|
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Raw seafood intoxication
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Vibrio parahemolyticus and Vibrio vulnificus
|
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Helicobacter Txt
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Bismuth salts; Metronidazole; Tetracycline (or amoxicillin)
|
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↑ risk of P. aeroginosa infection
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Burn patients & Cystic fibrosis
|
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Contact lens’ infection
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Pseudomonas aeroginosa
|
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Cat Bites
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Pasteurella multocida
|
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Undulant Fever
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Brucella
|
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Bordet Gengou Agar
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Bordetella pertusis ID
|
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Lowenstein-Jensen medium
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M. tuberculosis ID
|
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Cat Scratch Disease
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Bartonella henselae. Lesion can resemble Kaposi’s sarcoma.
Toxoplasmosis |
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Pink Eye
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Adenovirus (type 8)
|
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True Hemaphrodite
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Testes & Ovaries are present
|
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Pseudo Hemaphrodite
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External genitalia does not coincide w/ gonads
|
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Male Pseudo Hemaphrodite
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Testicular Feminization
|
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HLA Genes Location
|
6p
|
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Parvovirus B19
|
Fifth Disease: Erythema Infectiosum (ssDNA). Linked w/ sicle cell anemia
|
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Interferon MOA
|
Inhibits viral replication (translation or transcription)
|
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Acute Hemorrhagic Conjunctivitis
|
Seen w/ infections from Enterovirus & Coxsackie A
|
|
Parainfluenza Causes…
|
Croup (Laryngotracheobronchitis)
|
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Swimming Pool Conjunctivitis
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Adenovirus (types 3 & 4)
|
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RSV
|
Bronchiolitis in infants
|
|
Removed tonsils, find what virus
|
In 80%, Adenovirus. In the immunosuppressed, activation can occur
|
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Bone Fever
|
Dengue: Group B Togavirus, from the Arbovirus, transmitted by mosquitos
|
|
HbsAg
|
Appears in blood soon after infection, before onset of acute illness
Disappears w/in 4-6 months after the start of clinical illness |
|
HbeAg
|
Appears early acute phase, indicates higher risk of transmitting the disease
Disappears before HbsAg is gone |
|
Anti-Hbc
|
1. Present in beginning of clinical illness
2. Seen in the “window phase” |
|
Filamentous Bacteria
|
Actinomycetes = Nocardia; Actinomyces; Streptomyces
|
|
Listeria contaminates
|
Unpasteurized Milk, cheese, vegetables (coleslaw) in recent infections.
or by vaginal transmission during birth (granulomatosis infantiseptica) |
|
Shiga like Toxin
|
E. Coli 0157/H7: Hemorrhagic colitis & Hemorrhagic uremic syndrome
|
|
Necrotizing Fasciitis
|
Group A Streptococci
|
|
Relapsing Fever
|
Borrelia recurrentis
|
|
Loffler’s Medium
|
Corneybacterium diphtheriae
|
|
Chlamydiae Developmental Cycle
|
1. Elementary Body: infeccious particle that Enters the cell
2. Reticulate Body: made from elementary body. Replicates, differentiates and releases elementary bodies to infect other cells 3. W/ infection you will see Glycogen containing inclusions 4. Cell wall lacks muramic acid |
|
Trench Fever
|
Rochalimaea quintana
|
|
“Spotted Fever” Members
|
1. Rickettssia rickettsii (RMSF) & R. akari (rickettsial pox) in the U.S.
2. R. sibirica (tick typhus in China) & R. australis (typhus in Australia) |
|
Thrush Txt
|
Nystatin txts candidiasis of the mouth
|
|
Rose Bush Thorns
|
Have Sporothrix schenckii
|
|
Contact lens solution infection
|
Acanthamoeba
|
|
Filiariasis Causant
|
Wucheria bancrofti (infection aka elephantitis & wucheriasis
|
|
Freshwater lake infection
|
Causes amebic meningoencephalitis due to Naegleria fowleri
|
|
Reduviid bug bite
|
Transmits Trypanoma cruzi (Chagas’ disease): Romana’s Sign
|
|
Schistosoma Haematobium causes
|
Bladder calcificaiton & cancer
|
|
Schistosoma Mansoni causes
|
Presinusoidal HTN, splenomagaly, esophageal varices
|
|
Snail, intermediate host of…
|
Schistosomiasis
|
|
Ixodes scapularis transmits
|
Babesia (clinically rembles malaria) & Borelia burgdorferi
|
|
Nantucket Protozoa
|
Babesia microt
|
|
Infection by Reduviid Bug
|
Trypansoma cruzi: Chagas’ Disease
|
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Infection by TseTse Fly
|
Trypansoma brucei gambiense & rhodiense: African Sleeping Sickness
|
|
Infection by Sandfly
|
Leishmaniasis: Mucocutaneous Diseases by L. braziliensis & Visceral Disease by L. donovani & Dermal Leishman by L. tropica, mexicana, peruviana
|
|
Infection by Ixodes Tick
|
Babesia microti: Babesiosis & Borrelia burgdorferi: Lyme Disease
|
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Infection by Anopheles Mosquito
|
Malaria
|
|
Trophozoites w/ “Face-Like” Appearance
|
Giardia lamblia
|
|
Nonseptate Hyphae
|
Zygomycosis: Rhizopus & Mucor. Only mycosis w/o septate. Infect Ketoacidotic Diabetics.
|
|
Histoplasmosis Geography
|
Ohio, Mississippi, Misouri River valleys
|
|
Coocidioidomycosis Geography
|
Southwestern deserts, California
|
|
Blastomycosis Geography
|
States east of Mississippi River
|
|
Paracoccidioidomycosis Geography
|
Latin America
|
|
Roseola Infection, aka
|
Exanthema Subitum: “Sixth Disease” (Human Herpes Virus-6 dsDNA, enveloped)
|
|
Herpangina
|
“Hand-Foot-and-Mouth” Disease: Coxsackie A (Picornavirus +ssRNA)
|
|
Orthomyxovirus
|
1. –ssRNA, enveloped virus.
2. Spike Glycoproteins (peplomeres): HA = Hemagluttinin & NA = Neuraminidase. These peplomeres are what give the virus antigenis variation 3. Influenza A & B |
|
Paramyxovirus
|
1. –RNA, enveloped. Most common cause of respiratory infections in kids
2. Mumps 3. Croup(Parainfluenza virus) 4. Rubeola(Measles virus) 5. RSV |
|
Togavirus
|
1. +ssRNA, enveloped
2. 3 Day Measles: German Measles: Rubella/ Rubivirus 3. Encephalitis viruses: Alphaviruses: Eastern (more severe) and Western Equine Encephalitis |
|
Flaviviris
|
1. Dengue Fever – icterus & hemorrhage w/ blac vomit
2. Yellow fever 3. St. Louis Encephalitis – no hepatitis or hemorrhage |
|
Bunyavirus
|
1. –ssRNA, enveloped
2. California Encephalitis – severe bifrontal headaches 3. Hantavirus – hemorrhagic fever w/ acute resp. distress syndrome |
|
IgA Protease Activity
|
1. H. Influenzae (needs factors V & X for growth)
2. Strep. Pneumoniae 3. N. meningitidis 4. N. gonnorhoae 5. W/ this activity these bugs are able to colonize the oral mucosa. |
|
Diphtheria: ABCDEFG
|
1. Adenopathy
2. β Prophage encodes the exotoxin 3. Corneybacteria is Club shaped 4. Diphtheria 5. Elongation Factor II 6. Granules (metachromatic) |
|
Only ssDNA
|
Parvovirus: “Part of a virus”
|
|
Only dsRNA
|
Reovirus, “RepeatOvirus”
|
|
Naked RNA
|
“Naked for CPR”: Calcivirus; Picornovirus; Reovirus
|
|
2 circular DNAs
|
Papovavirus & Hepadnavirus
|
|
BK
|
Papovavirus. Seen in kidney transplant patients (causes renal disease)
|
|
Hepadna, Retrovirus?
|
No, but has reverse transcriptase
|
|
Picornovirus: “PERCH”
|
Poiliovirus; Echo; Rhino; Coxsackie; Hep A
|
|
Hemorrhagic Fevers
|
Filovirus & Bunyavirus (Hantavirus)
|
|
Segmented viruses
|
All are RNA: Orthomyxo; Arena; Bunya; Reo
|
|
Eclipse Phase
|
No internal virus. 1 total virus per cell
|
|
Latent Phase
|
No external virus. Extracellular virus found
|
|
Naked Capsid Virus
|
Nucleocapsid. DNA or RNA + Structural proteins
|
|
Enveloped Virus
|
Membrane. Nucleocapsid + Glycoprotein
|
|
Interferon
|
Non virus specific. Works by RNA endonuclease = digests viral DNA + inh viral prot synth
|
|
AIDS structural prots
|
Env: gp120, gp21
gag: p24 (capsid protein) Pol: reverse transcriptase |
|
AIDS regulatory prots
|
Tat, rev, nef
|
|
AIDS gp41 env prot
|
Transmembrane
|
|
AIDS gp120 env prot
|
Surface
|
|
AIDS p17 gag prot
|
Matrix
|
|
AIDS p24 gag prot
|
Capsid
|
|
AIDS p7p9 gag prot
|
Nucleocapsid
|
|
DNA Viruses
|
"HHAPPPPy" viruses
Herpes Hepadna Adeno Parvo: SS (-) Papilloma polyoma pox |
|
(+) RNA Viruses
|
C= Calici
P= Picorno R= Reo F= Flavi T= Toga C= Corona |
|
(-) RNA Viruses
|
F= Filo
O= Orthomyxo R= Rhabdo P= Paramyxo A= Arena B= Bunya |
|
Hepatitis Window Period
|
After HbsAg disappears & Before HbsAb appears
|
|
Hepatitis A
|
Picorna
|
|
Hepatitis B
|
Hepadna
|
|
Hepatitis C
|
Flavi
|
|
Hepatitis D
|
Delta
|
|
Hepatitis E
|
Calici
|
|
Downey Type II cells
|
EBV
|
|
Infection by Aedes Mosquito
|
Yellow Fever: Flavivirus: Black vomit, jaundice, high fever
|
|
“Hot T-Bone stEAk”: ILs
|
IL1 = ↑ Temp: HOT
IL2 = stimulate T cells IL3 = stimulate Bone Marrow stem cells’ growth & differentiation (GM CSF) IL4 = stimulate IgE (& IgG) IL5 = stimulate IgA (& eosinophils) |
|
ILs Secreted by CD4s
|
IL2, IL4, IL5, IFN gamma
|
|
ILs Secreted by Macrophages
|
IL1 & TNF α
|
|
C5a
|
Neutral chemotaxis.
When it is w/ C3a, participates in anaphylaxis |
|
C5 Convertase
|
When both Alternative and Classic pathways come together
Alternative: C3b, Bb, C3b + C3a → C5 Classic: 2b, 3b, C3a + C4b → C5 |
|
Only Richettssia not Intracellular
|
Quintana
|
|
Plasmodium Life Cycle
|
Sporozoites: from blood to liver
Primary tissue schizont Trophozoites: in RBC Erythrocytic schizont Merozoite: ruptured RBC Gametozyte Zygote: inside the mosquito |
|
Acanthamoeba
|
Star shaped cysts
|
|
Mucor, Rhizopus, Absidia
|
Nonseptate, filamentous, 90 degree branching, indian in, capsular halos
|
|
Cryptococcus Neoformans
|
Monomorphic
|
|
Candida
|
Yeast normally, pseudo & true hyphae in tissue infections
|
|
Aspergillus Fumigatum
|
45 degree branching point, asoc’d w/ cystic fibrosis & burns pt
|
|
Cocciodes
|
Hyphae in wild. Artroconidia. Arthocondida & Hyphae. Sherules w/ endospores
|
|
Histoplasma Cap
|
Hyphae in wild. Microcondida w/ tuberculate macrocondida. Fac intracellular. In the tissue it’s a yeast w/ a small neck.
|
|
Blastomycosis
|
Hyphae in wild
|
|
Sporothrix Schenkii
|
Hyphae in wild. Potas iodide in milk. Pneumonia in alcoholics.
|
|
PCP
|
Obligate parasite. Kills type I pneumo cells. Ground glass
|
|
Gram (-) Bugs w/ Exotoxins
|
E. Coli; V. Cholera; Bordetella Pertussis
|
|
Dermatophytes
|
Trichophyton: SHN
Microsporium: SH Epidermophyton: SN Tinea tavus: permanent hair loss |
|
E. Histolitica
|
Transmission: Cysts
Diagnosis: Trophozoites or cysts in stool |
|
Giardia
|
Transmission: Cysts
Diagnosis: Trophozoites or cysts in stool |
|
Cryptosporidium
|
Transmission: Cysts
Diagnosis: acid fast oocysts |
|
Balantium C.
|
Transmission: Cysts
Diagnosis: Trophozoites or cysts in stool |
|
Trichomonas V.
|
Transmission: Trophozoites
Diagnosis: Motile trophozoites |
|
Vivax
|
Fever: Benign 3 degrees
Fever spike: 48h Enlarged host cell |
|
Ovale
|
Fever: Benign 3 degrees
Fever spike: 48h oval/jagged |
|
Malariae
|
Fever: 4 degrees of Malarial
Fever spike: 72 irregular Crescent |
|
Falciparum
|
Fever: malignant 3 degrees
|
|
Only DNA virus to replicate in cytoplasm:
|
Pox
|
|
Only RNA virus to replicate in nucleus:
|
Influenza
|
|
The only protein capsule
|
Bacillus anthracis
|
|
Bordetella pertussis (whooping cough)
|
elicits lymphocytosis rather than granulocytosis
|
|
Cryptococcus neoformans
|
often lacks a capsule and, when stained with GMS, looks just like Pneumycistis carinii, except that Cryptococcus lacks the prominent nucleoli.
|
|
Weil Felix reaction:
|
(+)R. rickettssi & (+)Proteus vulgaris & P. mirabilis
|
|
Treponema pallidum (Syphilis) tests:
|
1)VDRL
2)FTA-Abs: most widely used 3)TPI (immobilization test – most expensive but the Gold Standard) |
|
IL1
|
Source: Monocytes, macrophages
Function: Stimulates T cell proliferation & IL2 produciton |
|
IL2
|
Source: Macrophages, T & NK cells
Function: Stim prolif of B, T & NK cell |
|
IL3
|
Source: T cells
Function: GF of tissue mast cells & hematopoietic stem cells |
|
IL4
|
Source: T cells
Function: ↑ growth of B & T cells/ ↑ HLA II Ags |
|
IL5
|
Source: T cells
Function: Maturation of B → plasma cell |
|
IL6
|
Source: T cells, monocytes
Function: Maturation of B & T cell/ (-) fibroblasts |
|
IFN α
|
Source: B cells, macrophages
Function: Antiviral activity |
|
IFN β
|
Source: Fibroblasts
Function: Antiviral activity |
|
IFN gamma
|
Source: T & NK cells
Function: Antiviral activity, (+) macrophages, ↑ HLA II Ags |