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18 Cards in this Set

  • Front
  • Back
Does a competitive inhibitor resemble the substrate? What about a noncompetitive inhibitor?
Yes; No.
Is a competitive inhibitor overcome by an increase in [S]? What about a noncompetitive inhibitor?
Yes; No.
Does a competitive inhibitor bind to the enzyme's active site? What about a noncompetitive inhibitor?
Yes; No.
What is a competitive inhibitor's effect on Vmax? What about a noncompetitive inhibitor's effect on Vmax?
None; Decreases Vmax.
What is a competitive inhibitor's effect on Km? What about a noncompetitive inhibitor's effect on Km?
Increases Km; No effect.
What is a competitive inhibitor's effect on overall pharmacodynamics? What about a noncompetitive inhibitor's overall effect on pharmacodynamics?
Decreases potency; Decreases efficacy.
What is the equation for Volume of Distribution (Vd)?
Vd = Amount of drug in the body/plasma drug concentration.
What is the equation for Clearance (CL)?
CL = 0.7 x Vd / t(1/2)
What is the equation for loading dose?
Loading Dose = Css x Vd
What is the equation for maintenance dose?
Maintenance Dose = Css x CL
What is the equation for Therapeutic Index (TI)?
TI = LD50 / ED50
What effect does a partial agonist have on pharmacodynamics?
Shifts the curve down (Decreases Vmax), can either increase or decrease potency.
What is the competitive antagonist in the case of benzo overdose?
Flumazenil.
What type of reactions occur during Phase I metabolism?
Hydrolysis, oxidation, reduction.
What type of reactions occur during Phase II metabolism?
Glucuronidation, sulfation, acteylation.
What are the P-450 inhibitors?
"MAGIC RACKS": Macrolides, amiodarone, grapefruit juice, isoniazid, cimedtidine, ritonavir, acute alcohol abuse, ciprofloxacin, ketoconazole, sulfonamides.
What are the P-450 inducers?
"BCG QRS": Barbituates, carbamazepine, griseofulvin, quinidine, rifampin, st. john's wart. Also, chronic alcohol abuse.
Treat acidic drug overdose with what? Treat basic drug overdose with what?
NaHCO3 for acidic drug OD (salicylates); NH4Cl for basic drug OD (amphetamines).