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72 Cards in this Set

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Bethanechol
Direct acting cholinergic agonist
Muscarinic Selectivity (M2 & M3)
Atonic bladder NEWLINE Neurognic atony, megacolon
Acetylcholine
Direct acting cholinergic agonist
Non-selective
Carbachol
Direct acting cholinergic agonist
Non-selective
Restricted to topical gluacoma treatment due to system effects
Cevimeline
Direct acting cholinergic agonist
Pilocarpine
Direct acting cholinergic agonist
Muscarinic Selectivity (M1, M2, & M3)
DOC for both narrow and wide angle glaucoma; Sometimes in Sjogren's due its potentcy as a secretagogue
Ambenomium
Indirect-acting, reversible cholinergic agonist
Treatment of myasthenia gravis; Longer-acting than neostigmine
Demecarium
Indirect-acting, reversible cholinergic agonist
Second line treatment of wide and narrow angle glaucoma
Donepezil
Indirect-acting, reversible cholinergic agonist
Alzheimer's disease
Edrophonium
Indirect-acting, reversible cholinergic agonist
Diagnostic test in myasthenia gravis
Galantamine
Indirect-acting, reversible cholinergic agonist
Alzheimer's disease
Pyridostigmine
Indirect-acting, reversible cholinergic agonist
Treatment of myasthenia gravis; Longer-acting than neostigmine
Rivastigmine
Indirect-acting, reversible cholinergic agonist
Alzheimer's disease
Tacrine
Indirect-acting, reversible cholinergic agonist
Alzheimer's disease
Neostigmine
Indirect-acting, reversible cholinergic agonist
Does not cross BBB
Physostigmine
Indirect-acting, reversible cholinergic agonist
Can cross BBB to enter CNS
Echothiophate
Indirect Acting - Irreversible phosphorylation of acetylcholinesterase
Toxin, no significant clinical use NEWLINE Many of the toxic effects can be overcome with atropine
Pralidoxime
Reactivation of acetylcholinesterase
Must be used prior to enzyme-toxin aging process
Atropine
Antimuscarinic Agent (M1, M2, & M3)
Treatment of bradycardia; cholinesterase inhibitor overdose; ophthalmologically, causes cycloplegia and mydriasis; treatment of urgent bladder due to cystitis
Cyclopentolate
Antimuscarinic Agent
Induces cycloplegia and mydriasis
Ipratropium
Antimuscarinic Agent
M3 activity only because it is inhaled
Treatment of asthma in patients who don't tolerate β-agonists
Scopolamine
Antimuscarinic Agent
Greater CNS activity than atropine
Treatment of motion sickness; Amnestic effect in anesthetic procedures
Tropicamide
Antimuscarinic Agent
Induces cycloplegia and mydriasis
Propantheline
Antimuscarinic agent
Actions primarily limited to GI/GU
M3 muscarinic receptors
Urinary incontinence; PUD, nervous stomach
Benztropine
Antimuscarinic agent
Clinical importance lies in activity in corpus striatum
Parkinson's disease
Mecamylamine
Ganglionic Blockers
Nicotinic blockade
Used to lower blood pressure in emergency situations
Mecamylamine
Ganglionic Blockers
Nicotinic blockade
Used to lower blood pressure in emergency situations
Atracurium
Neuromuscular Blockers - Nondepolarizing
Cisatracurium
Neuromuscular Blockers - Nondepolarizing
Doxacurium
Neuromuscular Blockers - Nondepolarizing
Metocurine
Neuromuscular Blockers - Nondepolarizing
Mivacurium
Neuromuscular Blockers - Nondepolarizing
Pancuronium
Neuromuscular Blockers - Nondepolarizing
Rocuronium
Neuromuscular Blockers - Nondepolarizing
Tubocurarine
Neuromuscular Blockers - Nondepolarizing
Vecuronium
Neuromuscular Blockers - Nondepolarizing
Succinylcholine
Neuromuscular Blockers - Depolarizing
Albuterol
Direct acting adrenergic agonists
β2 - short acting
Asthma
Clonidine
Direct acting adrenergic agonists
α2
Minimize CNS symptoms that accompany opiate and benz withdrawal
Dobutamine
Direct acting adrenergic agonists
Catecholamine
β1
Increases CO in CHF; post-cardiac surgery inotrope; does not sig. increase myocardial O2 demand
Dopamine
Direct acting adrenergic agonists
Catecholamine
, α1, β1, D1, D2
DOC for shock
Epinephrine
Direct acting adrenergic agonists
Catecholamine
α1, α2, β1, β2
DOC in severe bronchspasm; glaucoma; anaphylactic shock; cardiac arrest; anesthetic adjunct
Formoterol
Direct acting adrenergic agonists
β2 - long acting
Asthma
Isoproterenol
Direct acting adrenergic agonists
Catecholamine
β1, β2
Not commonly used therapeutically
Metaproterenol
Direct acting adrenergic agonists
Non-catecholamine
β2 > β1
Bronchospasm, asthma, bronchiolitis, COPD
Methoxamine
Direct acting adrenergic agonists
α1>α2
Relieve attacks of PSVT; overcome hypotension related to halothane anesthetic use during surgery
Norepinephrine
Direct acting adrenergic agonists
Catecholamine
α1, α2, β1
Severe hypotension; septic shock
Phenylephrine
Direct acting adrenergic agonists
α1
Non-catecholamine
Elevates SVR; termination of SVT; Topical nasal decongestant; Ophthalmologically to induce mydriasis
Pirbuterol
Direct acting adrenergic agonists
β2 - short acting
Asthma
Salmeterol
Direct acting adrenergic agonists
β2 - long acting
Nocturnal, symptomatic asthma
Terbutaline
Direct acting adrenergic agonists
β2 - short acting
Only agent used for status asthmaticus
Ephedrine
Mixed Action
α, β
Penetrates CNS Non-catecholamine
Nasal decongestant (nasal vascular effects); orthostatic hypotension; promotes urinary continence
Pseudoephrine
Mixed Action
α, β
Penetrates CNS
Similar to ephedrine, but less potent
Alfuzosin
α-Blockers
α1-selective
Symptomatic BPH
Doxazosin
α-Blockers
α1-selective
Hypertension
Phenoxybenzamine
α-adrenergic blocker, non-selective
Irreversible modification
Treatment of pheochromocytoma; autonomic hyperreflexia in paraplegics
Phentolamine
α-adrenergic blocker, non-selective
Short-term control of hypertension in pheochromocytoma; Tx of sympathomimetic amine overdose
Prazosin
α-Blockers
α1-selective
Hypertension
Tamsulosin
α-Blockers
α1-selective
Symptomatic BPH
Terazosin
α-Blockers
α1-selective
Hypertension
Yohimbine
α-Blockers
α2-selective
Sexual stimulant; acts via inhibition of sympathetic outflow to periphery
Acebutolol
β-Blockers
Cardioselective (β1)
Has intrinsic sympathomimetic activity (partial agonist)
Hypertensive patients with impaired pulmonary function
Atenolol
β-Blockers
Cardioselective (β1)
Hypertensive patients with impaired pulmonary function
Carvedilol
β-Blockers
α1, β1, β2
Treatment of hypertension in African American patients; has vasodilatory properties
Esmolol
β-Blockers
Cardioselective (β1)
Hypertensive patients with impaired pulmonary function
Labetalol
β-Blockers
α1, β1, β2
Treatment of hypertension in African American patients; has vasodilatory properties
Metoprolol
β-Blockers
Cardioselective (β1)
Hypertensive patients with impaired pulmonary function
Nadolol
β-Blockers
Non-selective
Fewer CNS side-effects and more potent than propranolol
Pindolol
β-Blockers
Non-selective
Has intrinsic sympathomimetic activity (partial agonist)
Hypertension (decreased CO and renin release); glaucoma; migraine prophylaxis; hyperthyroidism; angina pectoris; myocardial infarction
Propranolol
β-Blockers
Non-selective
Hypertension (decreased CO and renin release); glaucoma; migraine prophylaxis; hyperthyroidism; angina pectoris; myocardial infarction
Timalol
β-Blockers
Non-selective
Used ophthalmologically as topical agent for glaucoma
Guanethidine
Blocks the release of stored norepinephrine from storage vesicles
No therapeutic use
Reserpine
Blocks Mg2+/ATP-dpendent transport of biogenic amines (NE, Dopamine, 5HT) from cytoplasm into storage vesicles
No therapeutic use