Usmle Pharmacology 1

Front 1

Clozapine side effects:

1.) ____________
2.)_____________

Back 1

1.) Agranulocytosis
2.) Seizures

Front 2

MOA for drugs that end in "-stigmine"?

Back 2

Anti-Cholinesterase action

(prevents ACh breakdown; Indirect cholinergeric agonist)

Front 3

MOA for drugs that have "-trop-" in them?

Back 3

Muscarinic ANTAGONISTS

Parasympathetolytics (atropine)

Front 4

Name two muscarinic ANTAGONISTS that do not have "-trop-" in their names:

Back 4

Scopolamine (CNS)
Oxybutynin (Bladder)

Front 5

How can you tell if a ß-blocker has ß1 activity or mixed activity?

Back 5

ß1 blockers are the 1st half the alphabet (A-M)

Atenolol
Acebutolol
Betaxolol
Esmolol (short acting)
Metoprolol (best post-MI)



Conversely "N-Z" ß blockers are non-selective or more ß2

Front 6

Antidote for Iron toxicity?

Back 6

Deferoxamine

Front 7

Antidote for Lead toxicity?

Back 7

A VIRTUAL BUFFET!!!!

EDTA

Dimercaprol

Succimer

Penicillamine

Front 8

Antidote for Mercury toxicity?

Back 8

Di-MERC-aprol



(BONUS: whatever works on Hg+ & Cu+ will work for Arsenic and Au+)

Front 9

Antidote for Copper toxicity?

Back 9

Penicillamine

(Wilson!)

Front 10

Antidote for tPA?


(including streptokinase/urokinase)

Back 10

Aminocaproic acid

(inhibits plasmin; no more plasminogen around to bust clots)

Front 11

Antidote for ß-blocker overdose?

Back 11

Glucagon!




(Atropine/CCBs will work too)

Front 12

Your hospital can't afford Anti-digoxin ABs. The intern just screwed up the Digitalis dose. What do you do?

Back 12

Stop Dig!

Give K+ and Mg+ til normalized

Follow ACLS like a hawk

Front 13

Organophosphate (insecticide) antidote?

Back 13

Pralidoxime
(regenerates ACh-esterase)

Atropine (may help sxs)

Front 14

Pilocarpine MOA and uses?

Back 14

Cholinomimetic agonist

Stimulates Saliva, Sweat, Tears


Cry, Sweat and Drool on your "Pillow-carpine"

Front 15

Bethanechol MOA and uses?

Back 15

Cholinomimetic

Gets Bowel and Bladder moving
(post-op ileus)

Front 16

Drug used in treatment of Alz dx

Prevents ACh breakdown

Back 16

Donepazil

(also galantamine, rivastigmine)

Front 17

This drug "PHYxes" atropine overdose

Back 17

PHYsostigmine

Front 18

Drug used to get rid of Myesthenia Gravis?

Back 18

Py-RID-ostigmine

Front 19

Side fx may include:

TORSADES!!!

Back 19

Class IA antiarrhythmics
(Double Quarter Pounder)

Class III antiarrhythmics
(Sotalol, Dofetilide, Bretylium, Ibutilide)

NOT-Amiodarone

Front 20

PTU/Methimazole side effects?

Back 20

Agranulocytosis

Front 21

Side fx may include:

Gynecomastia

*Some Drugs Create Awesome Knockers*

Back 21

Spironolactone
Digitalis
Cimetidine
Alcohol
Ketoconazle

Front 22

Side fx may include:

RASH! (Stevens-Johnson Syn)
3 famous catagories
1.) _____________
2.) _____________
3.) _____________

Back 22

Szr rxs (ethosux, lamotrig, carba)

SULFA drugs

Penicillins

Front 23

What are the most famous SULFA drugs?

Back 23

Be a Sulfa FACTS Pro:

Sulfonamides Sulfonylureas Sulfasalazine

F urosemide
A cetazolamide
C elecoxib
T hiazides
S umatriptan

Probenacid

Front 24

What drugs Induce P-450?

Back 24

BCG PQRS

Barbiturates
Carbamazepine
Griseofulvin
Phenytoin
Quinidine
Rifampin
St. John's wort

Front 25

What drugs Inhibit P-450?

Back 25

PICK EGS 'ARD

PI's (HIV protease inhibitors)
Isoniazid (INH)
Cimetidine
Ketoconazole

Erythromycin (macrolides)
GRAPFRUIT juice
SULFA drugs

Amiodarone
Ritonavir (duh)
Diltiazem

Front 26

Drugs that cause LONG QT:

1.) Antibiotics (2)
2.) Antipsychotics (2)
3.) Anti-HIV (1)
4.) Antiarrhythmics (2)

Back 26

1.) Macrolides + choraquine
2.) Risperdone, Haloperidol
3.) Protease Inhibitors
4.) Class IA's and Class III's

Front 27

Class IA antiarrhythmics?
(Double Quarter Pounder)

Class IB antiarrhythmics?
(Mayo Lettuce Tomato)

Class IC antiarrhythmics?
(Fries Please!)

Back 27

D isopyramide
Q uinidine
P rocainamide

M exilitine
L idocaine
T ocainide

F lecainide
P ropafenone

Front 28

What are the four "R"s of rifampin?

1)____________
2)____________
3)____________
4)____________

Back 28

1.) RNA polymerase Inhibitor
2.) Revs up P-450
3.) Resistance if given alone
4.) Red-orange fluids

Front 29

Name the MOA and drug for the RIPE tx in TB:

R
I
P
E

Back 29

Rifampin-blocks RNA polymerase
INH - blocks mycolic acid syn
Pyrazinamide- same INH but only works in acid pH (in phagosome)
Ethambutol - blocks arabinosyltransferase (prevents cell wall carbohydrate polymerization)

Front 30

Altough rifampin is NEVER given alone for TB tx, it ok to use as prophylaxis for TWO other dx's:

1.) ________________
2.) ________________

Back 30

rifampin prophylaxis:

1.) N. meningitis
2.) H. influenza (type B)

Front 31

Which TB drug causes RED-GREEN color blindness?

Back 31

Ethambutol

Front 32

Single prophylaxis for TB?

Back 32

INH

Isoniazid

Front 33

Single prophylaxis for MAC?

Back 33

Azithromycin

Front 34

Before it can work, INH must be converted to its active metabolite.

What converts INH?

Back 34

Bacterial catalase-peroxidase (KatG)

...converts INH to its active form

Front 35

Anti-helminth Rx that increases GABA transmission?

Back 35

Ivermectin

Front 36

Anti-helminth Rx that increases Ca+ influx?

Back 36

Praziquantel

Front 37

Anti-hilminth Rx that blocks blocks glucose uptake?

Back 37

Mebendazole

Front 38

Name the three enzymes most likely to breakdown DA and futz with your Parkinson tx!

1.) ________
2.) ________
3.) ________

Back 38

1.) MAO (CNS only)
2.) COMT (peripheral)
3.) DDI (peripheral)

Front 39

These drugs is given with L-dopa in order to prevent early metabolism by COMT:

1.) ______________
2.) ______________

Back 39

1.) Tolcapone
2.) Entacapone


(Bonus: Which of these has liver toxicity and CNS penetration?)

Front 40

This drug is given to break DA breakdown in the CNS by MAO-B:

1.) ______________

Back 40

Selegiline

Front 41

Describes the concentration of inhaled anesthetic that anesthetizes 50% of ppl: __________________


How is this term related to potency?

Back 41

Mininum Aveolar Concentration


Is INVERSELY proportional to POTENCY