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41 Cards in this Set

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Clozapine side effects:

1.) ____________
2.)_____________
1.) Agranulocytosis
2.) Seizures
MOA for drugs that end in "-stigmine"?
Anti-Cholinesterase action

(prevents ACh breakdown; Indirect cholinergeric agonist)
MOA for drugs that have "-trop-" in them?
Muscarinic ANTAGONISTS

Parasympathetolytics (atropine)
Name two muscarinic ANTAGONISTS that do not have "-trop-" in their names:
Scopolamine (CNS)
Oxybutynin (Bladder)
How can you tell if a ß-blocker has ß1 activity or mixed activity?
ß1 blockers are the 1st half the alphabet (A-M)

Atenolol
Acebutolol
Betaxolol
Esmolol (short acting)
Metoprolol (best post-MI)



Conversely "N-Z" ß blockers are non-selective or more ß2
Antidote for Iron toxicity?
Deferoxamine
Antidote for Lead toxicity?
A VIRTUAL BUFFET!!!!

EDTA

Dimercaprol

Succimer

Penicillamine
Antidote for Mercury toxicity?
Di-MERC-aprol



(BONUS: whatever works on Hg+ & Cu+ will work for Arsenic and Au+)
Antidote for Copper toxicity?
Penicillamine

(Wilson!)
Antidote for tPA?


(including streptokinase/urokinase)
Aminocaproic acid

(inhibits plasmin; no more plasminogen around to bust clots)
Antidote for ß-blocker overdose?
Glucagon!




(Atropine/CCBs will work too)
Your hospital can't afford Anti-digoxin ABs. The intern just screwed up the Digitalis dose. What do you do?
Stop Dig!

Give K+ and Mg+ til normalized

Follow ACLS like a hawk
Organophosphate (insecticide) antidote?
Pralidoxime
(regenerates ACh-esterase)

Atropine (may help sxs)
Pilocarpine MOA and uses?
Cholinomimetic agonist

Stimulates Saliva, Sweat, Tears


Cry, Sweat and Drool on your "Pillow-carpine"
Bethanechol MOA and uses?
Cholinomimetic

Gets Bowel and Bladder moving
(post-op ileus)
Drug used in treatment of Alz dx

Prevents ACh breakdown
Donepazil

(also galantamine, rivastigmine)
This drug "PHYxes" atropine overdose
PHYsostigmine
Drug used to get rid of Myesthenia Gravis?
Py-RID-ostigmine
Side fx may include:

TORSADES!!!
Class IA antiarrhythmics
(Double Quarter Pounder)

Class III antiarrhythmics
(Sotalol, Dofetilide, Bretylium, Ibutilide)

NOT-Amiodarone
PTU/Methimazole side effects?
Agranulocytosis
Side fx may include:

Gynecomastia

*Some Drugs Create Awesome Knockers*
Spironolactone
Digitalis
Cimetidine
Alcohol
Ketoconazle
Side fx may include:

RASH! (Stevens-Johnson Syn)
3 famous catagories
1.) _____________
2.) _____________
3.) _____________
Szr rxs (ethosux, lamotrig, carba)

SULFA drugs

Penicillins
What are the most famous SULFA drugs?
Be a Sulfa FACTS Pro:

Sulfonamides Sulfonylureas Sulfasalazine

F urosemide
A cetazolamide
C elecoxib
T hiazides
S umatriptan

Probenacid
What drugs Induce P-450?
BCG PQRS

Barbiturates
Carbamazepine
Griseofulvin
Phenytoin
Quinidine
Rifampin
St. John's wort
What drugs Inhibit P-450?
PICK EGS 'ARD

PI's (HIV protease inhibitors)
Isoniazid (INH)
Cimetidine
Ketoconazole

Erythromycin (macrolides)
GRAPFRUIT juice
SULFA drugs

Amiodarone
Ritonavir (duh)
Diltiazem
Drugs that cause LONG QT:

1.) Antibiotics (2)
2.) Antipsychotics (2)
3.) Anti-HIV (1)
4.) Antiarrhythmics (2)
1.) Macrolides + choraquine
2.) Risperdone, Haloperidol
3.) Protease Inhibitors
4.) Class IA's and Class III's
Class IA antiarrhythmics?
(Double Quarter Pounder)

Class IB antiarrhythmics?
(Mayo Lettuce Tomato)

Class IC antiarrhythmics?
(Fries Please!)
D isopyramide
Q uinidine
P rocainamide

M exilitine
L idocaine
T ocainide

F lecainide
P ropafenone
What are the four "R"s of rifampin?

1)____________
2)____________
3)____________
4)____________
1.) RNA polymerase Inhibitor
2.) Revs up P-450
3.) Resistance if given alone
4.) Red-orange fluids
Name the MOA and drug for the RIPE tx in TB:

R
I
P
E
Rifampin-blocks RNA polymerase
INH - blocks mycolic acid syn
Pyrazinamide- same INH but only works in acid pH (in phagosome)
Ethambutol - blocks arabinosyltransferase (prevents cell wall carbohydrate polymerization)
Altough rifampin is NEVER given alone for TB tx, it ok to use as prophylaxis for TWO other dx's:

1.) ________________
2.) ________________
rifampin prophylaxis:

1.) N. meningitis
2.) H. influenza (type B)
Which TB drug causes RED-GREEN color blindness?
Ethambutol
Single prophylaxis for TB?
INH

Isoniazid
Single prophylaxis for MAC?
Azithromycin
Before it can work, INH must be converted to its active metabolite.

What converts INH?
Bacterial catalase-peroxidase (KatG)

...converts INH to its active form
Anti-helminth Rx that increases GABA transmission?
Ivermectin
Anti-helminth Rx that increases Ca+ influx?
Praziquantel
Anti-hilminth Rx that blocks blocks glucose uptake?
Mebendazole
Name the three enzymes most likely to breakdown DA and futz with your Parkinson tx!

1.) ________
2.) ________
3.) ________
1.) MAO (CNS only)
2.) COMT (peripheral)
3.) DDI (peripheral)
These drugs is given with L-dopa in order to prevent early metabolism by COMT:

1.) ______________
2.) ______________
1.) Tolcapone
2.) Entacapone


(Bonus: Which of these has liver toxicity and CNS penetration?)
This drug is given to break DA breakdown in the CNS by MAO-B:

1.) ______________
Selegiline
Describes the concentration of inhaled anesthetic that anesthetizes 50% of ppl: __________________


How is this term related to potency?
Mininum Aveolar Concentration


Is INVERSELY proportional to POTENCY