Usmle Neuro Drug Class Quiz

Front 1

phenytoin

Back 1

antiseizure
increase Na channel inactivity

gingival hyperplasia
SLE like syndrome
p450
ataxia

1st line prophylaxis

Front 2

carbamezapine

Back 2

antiseizure
increase Na channel inactivity

agranulocytosis, aplastic anemia
ataxia
teratogenic
p450

trigeminal neuralgia

Front 3

gabapentin

Back 3

antiseizure
increase GABA release

ataxia

peripheral neuropathy

Front 4

phenobarbital

Back 4

barbiturate
prolong Cl channel, GABA

seizure prophylax pregnant
(also class Ib antiarryth)

p450
sedation, addiction

no OD treatment (mng sx's)

Front 5

valproic acid

Back 5

ALL seizures (incl absence)

inactivate Na channel
increase GABA concentration

teratogenic
GI
rare liver failure
weight GAIN

binds carnitine (inhibits FA oxidation)

Front 6

ethosuximide

Back 6

absence seizures
inhibit Ca channels (T type)

urticaria
Stevens-Johnson

Front 7

diazepam, lorazepam

Back 7

benzo, freq of Cl (GABA)

acute seizures (MgSO4)

sedation, tolerance, dependence

Front 8

lamotrigine

Back 8

antiseizure
block VG Na channel

Stevens-Johnson syndrome

Front 9

topiramate

Back 9

antiseizure
Na channel & GABA increase

kidney stones, weight LOSS, cognition

Front 10

thiopental

Back 10

barbiturate
(phenobarb, pentobarb, secobarb)

duration Cl chann (GABA)

no OD tx except manage sx's

respiratory depression

NOT if porphyria

Front 11

chlordiazepoxide

Back 11

benzo

Front 12

triazolam

Back 12

benzo

short acting

Front 13

oxazolam

Back 13

benzo

short acting

Front 14

midazolam

Back 14

benzo

short acting

Front 15

flumazenil

Back 15

treat benzo OD

competitive antagonist of GABA R

Front 16

Thioridizine

Back 16

neuroleptic (antipsych)
block D2 receptors

tardive diskinesia
EPS symptoms
neuroleptic malignant syndrome (tx w/dantrolene & DA agonists)

Front 17

evolution of EPS side effects

Back 17

neuroleptics

4 hr: dystonia
4 day: akinesia
4 wk: akathisia
4 mo: tardive dyskinesia (irreversible)

Front 18

haloperidol

Back 18

neuroleptic

EPS symptoms
gynecomastia
anticholinergic
hypotension

Front 19

fluphenazine

Back 19

neuroleptic

EPS symptoms
gynecomastia
anticholinergic
hypotension

Front 20

chlorpromazine

Back 20

neuroleptic

EPS symptoms
gynecomastia
anticholinergic
hypotension

(SLE effect)

Front 21

clozapine

Back 21

atypical neuroleptic (fewer EPS & antichol SE's)
block 5 HT and DA receptors

agranulocytosis

Front 22

olanzapine

Back 22

atypical neuroleptic (fewer EPS & antichol SE's)
block 5 HT and DA receptors

OCD, anxiety, Tourette, mania, depression

Front 23

resperidone

Back 23

atypical neuroleptic (fewer EPS & antichol SE's)
block 5 HT and DA receptors

Front 24

Lithium

Back 24

antiphsycotic

mech unknown (maybe inhibit PI cascade)

tremor
DI
hypOthyroidism
teratogenic

Front 25

antipsychotic classes

Back 25

neuroleptic (D2)
atypical neuroleptic (5HT, DA R)
Li (maybe PI)

Front 26

antidepressant classes

Back 26

SSRI
MAOI
Tricyclic
heterocyclic

Front 27

sertraline

Back 27

SSRI

serotonin synd w/MAOI
sexual dysfunction

Front 28

paroxetine

Back 28

SSRI (paxil)

serotonin synd w/MAOI
sexual dysfunction

Front 29

citalopram

Back 29

SSRI

serotonin synd w/MAOI
sexual dysfunction

Front 30

hyperthermia, muscle rigidity, CV collapse

Back 30

serotonin syndrome

SSRI + MAOI (or meperidine from ER)

or MAOI + beta agonist (isoproter, dobutamine, terbutiline, albuerol)

Front 31

Imipramine

Back 31

TCA
block reuptake of NE & 5HT

bedwetting

sedation, alpha blocker,anticholinergic

Front 32

amitriptyline

Back 32

TCA
block NE & 5 HT reuptake

tertiary TCA, more SE's

Front 33

desipramine

Back 33

TCA
block NE & 5HT reuptake

least sedating

Front 34

nortriptyline

Back 34

TCA
block NE & 5 HT reuptake

secondary less SE's
use to avoid confusion in elderly

Front 35

clomipramine

Back 35

TCA
block NE & 5HT reuptake

can use for OCD

Front 36

doxepine

Back 36

TCA
block NE & 5 HT reuptake

Front 37

bupropion

Back 37

wellbutrin

HCA (heterocyclic antidep)
mech unclear

seizure in bulimia

no sexual SE's

Front 38

venlafaxine

Back 38

heterocyclic AD
block NE 5HT & DA reuptake


depression, gen anxiety
SE: stimulant, HTN

Front 39

mirtazapine

Back 39

heterochclic AD
alpha 2 antagonist (clonidine is agonist)

SE: weight gain (appetite), dry mouth

Front 40

maprotiline

Back 40

HCA
block NE reuptake

SE: sedation, orthostatic hypotension

Front 41

trazodone

Back 41

HCA
block 5HT uptake

SE: priapism, postural hypotension

Front 42

phenelzine

Back 42

MAOI

HTN crisis w/tyramine

NOT w/SSRI or beta agonist

Front 43

buspirone

Back 43

(not in bible)
Buspar
for anxiety

Front 44

anesthetic classes

Back 44

inhaled
IV
Local
NM blockers

Front 45

fluranes

Back 45

inhaled anesthetic
(also halothane)

malignant hyperthermia

Front 46

halothane

Back 46

inhaled anesthetic

hepatotoxic

Front 47

methoxyflurane

Back 47

inhaled anesthetic

nephrotoxic

Front 48

enflurane

Back 48

inhaled anesthetic

proconvulsant

Front 49

IV anesthetics

Back 49

barbs:
-thiopental: induction & short

benzos:
-midazolam for endoscopy
-post op resp depress
-hypoTN tx w/flumazenil

arylcylohexmines (ketamine)

opiates (mophine, fentenyl)

propofol- less nausea

Front 50

thiopental

Back 50

low MAC, high solubil: induction & short procedures

Front 51

midazolam

Back 51

short acting benzo
anesthesia for colonoscopy

BP drop tx w/flumazenil

Front 52

ketamine

Back 52

PCP analog

increase cerebral BF

Front 53

fentanyl

Back 53

opiate

Front 54

propofol

Back 54

rapid anesthesia induction

less nausea

Front 55

succinylcholine

Back 55

depolarizing NM blocker

activates nicotinic R

neostigmine (AChE inhib) NOT reverse (use butylcholinesterase)

Front 56

tubocurarine

Back 56

non-depolarizing NM blocker

prevents nicotinic binding

tx w/neostigmine