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56 Cards in this Set

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phenytoin
antiseizure
increase Na channel inactivity

gingival hyperplasia
SLE like syndrome
p450
ataxia

1st line prophylaxis
carbamezapine
antiseizure
increase Na channel inactivity

agranulocytosis, aplastic anemia
ataxia
teratogenic
p450

trigeminal neuralgia
gabapentin
antiseizure
increase GABA release

ataxia

peripheral neuropathy
phenobarbital
barbiturate
prolong Cl channel, GABA

seizure prophylax pregnant
(also class Ib antiarryth)

p450
sedation, addiction

no OD treatment (mng sx's)
valproic acid
ALL seizures (incl absence)

inactivate Na channel
increase GABA concentration

teratogenic
GI
rare liver failure
weight GAIN

binds carnitine (inhibits FA oxidation)
ethosuximide
absence seizures
inhibit Ca channels (T type)

urticaria
Stevens-Johnson
diazepam, lorazepam
benzo, freq of Cl (GABA)

acute seizures (MgSO4)

sedation, tolerance, dependence
lamotrigine
antiseizure
block VG Na channel

Stevens-Johnson syndrome
topiramate
antiseizure
Na channel & GABA increase

kidney stones, weight LOSS, cognition
thiopental
barbiturate
(phenobarb, pentobarb, secobarb)

duration Cl chann (GABA)

no OD tx except manage sx's

respiratory depression

NOT if porphyria
chlordiazepoxide
benzo
triazolam
benzo

short acting
oxazolam
benzo

short acting
midazolam
benzo

short acting
flumazenil
treat benzo OD

competitive antagonist of GABA R
Thioridizine
neuroleptic (antipsych)
block D2 receptors

tardive diskinesia
EPS symptoms
neuroleptic malignant syndrome (tx w/dantrolene & DA agonists)
evolution of EPS side effects
neuroleptics

4 hr: dystonia
4 day: akinesia
4 wk: akathisia
4 mo: tardive dyskinesia (irreversible)
haloperidol
neuroleptic

EPS symptoms
gynecomastia
anticholinergic
hypotension
fluphenazine
neuroleptic

EPS symptoms
gynecomastia
anticholinergic
hypotension
chlorpromazine
neuroleptic

EPS symptoms
gynecomastia
anticholinergic
hypotension

(SLE effect)
clozapine
atypical neuroleptic (fewer EPS & antichol SE's)
block 5 HT and DA receptors

agranulocytosis
olanzapine
atypical neuroleptic (fewer EPS & antichol SE's)
block 5 HT and DA receptors

OCD, anxiety, Tourette, mania, depression
resperidone
atypical neuroleptic (fewer EPS & antichol SE's)
block 5 HT and DA receptors
Lithium
antiphsycotic

mech unknown (maybe inhibit PI cascade)

tremor
DI
hypOthyroidism
teratogenic
antipsychotic classes
neuroleptic (D2)
atypical neuroleptic (5HT, DA R)
Li (maybe PI)
antidepressant classes
SSRI
MAOI
Tricyclic
heterocyclic
sertraline
SSRI

serotonin synd w/MAOI
sexual dysfunction
paroxetine
SSRI (paxil)

serotonin synd w/MAOI
sexual dysfunction
citalopram
SSRI

serotonin synd w/MAOI
sexual dysfunction
hyperthermia, muscle rigidity, CV collapse
serotonin syndrome

SSRI + MAOI (or meperidine from ER)

or MAOI + beta agonist (isoproter, dobutamine, terbutiline, albuerol)
Imipramine
TCA
block reuptake of NE & 5HT

bedwetting

sedation, alpha blocker,anticholinergic
amitriptyline
TCA
block NE & 5 HT reuptake

tertiary TCA, more SE's
desipramine
TCA
block NE & 5HT reuptake

least sedating
nortriptyline
TCA
block NE & 5 HT reuptake

secondary less SE's
use to avoid confusion in elderly
clomipramine
TCA
block NE & 5HT reuptake

can use for OCD
doxepine
TCA
block NE & 5 HT reuptake
bupropion
wellbutrin

HCA (heterocyclic antidep)
mech unclear

seizure in bulimia

no sexual SE's
venlafaxine
heterocyclic AD
block NE 5HT & DA reuptake


depression, gen anxiety
SE: stimulant, HTN
mirtazapine
heterochclic AD
alpha 2 antagonist (clonidine is agonist)

SE: weight gain (appetite), dry mouth
maprotiline
HCA
block NE reuptake

SE: sedation, orthostatic hypotension
trazodone
HCA
block 5HT uptake

SE: priapism, postural hypotension
phenelzine
MAOI

HTN crisis w/tyramine

NOT w/SSRI or beta agonist
buspirone
(not in bible)
Buspar
for anxiety
anesthetic classes
inhaled
IV
Local
NM blockers
fluranes
inhaled anesthetic
(also halothane)

malignant hyperthermia
halothane
inhaled anesthetic

hepatotoxic
methoxyflurane
inhaled anesthetic

nephrotoxic
enflurane
inhaled anesthetic

proconvulsant
IV anesthetics
barbs:
-thiopental: induction & short

benzos:
-midazolam for endoscopy
-post op resp depress
-hypoTN tx w/flumazenil

arylcylohexmines (ketamine)

opiates (mophine, fentenyl)

propofol- less nausea
thiopental
low MAC, high solubil: induction & short procedures
midazolam
short acting benzo
anesthesia for colonoscopy

BP drop tx w/flumazenil
ketamine
PCP analog

increase cerebral BF
fentanyl
opiate
propofol
rapid anesthesia induction

less nausea
succinylcholine
depolarizing NM blocker

activates nicotinic R

neostigmine (AChE inhib) NOT reverse (use butylcholinesterase)
tubocurarine
non-depolarizing NM blocker

prevents nicotinic binding

tx w/neostigmine