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90 Cards in this Set
- Front
- Back
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What tumor is associated w/ abl?
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CML
Oncogene |
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What tumor is associated w/ c-myc?
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Burkitt's lymphoma
Oncogene |
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What tumor is associated w/ bcl-2?
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Follicular and undifferentiated lymphomas
Oncogene |
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What tumor is associated w/ erb-B2?
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Breat, ovarian and gastric carcinoma
Oncogene |
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What tumor is associated w/ ras?
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Colon carcinoma
Oncogene |
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What tumor is associated w/ L-myc?
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Lung tumor
Oncogene |
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What tumor is associated w/ N-myc?
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Neuroblastoma
Oncogene |
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What tumor is associated w/ ret?
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MEN types II and III
Oncogene |
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What tumor is associated w/ c-kit?
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Gastrointestinal stromal tumor
Oncogene |
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What tumor is associated w/ Rb and where is it located?
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Retinoblastoma, osteosarcoma
13q |
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What tumor is associated w/ BRCA1 and where is it located?
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Breast and ovarian
17q |
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What tumor is associated w/ BRCA2 and where is it located?
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Breast
13q |
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What tumor is associated w/ p53 and where is it located?
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Most cancers, Li-Fraumeni syndrome
17p |
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What tumor is associated w/ p16 and where is it located?
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Melanoma
9p |
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What tumor is associated w/ APC and where is it located?
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Colorectal ca
5q |
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What tumor is associated w/ WT1 and where is it located?
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Wilms' tumor
11p |
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What tumor is associated w/ NF1 and where is it located?
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Neurofibromatosis I
17q |
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What tumor is associated w/ NF2 and where is it located?
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Neurofibromatosis II
22q |
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What tumor is associated w/ DPC and where is it located?
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Pancreatic cancer
18q |
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What tumor is associated w/ DCC and where is it located?
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Colon cancer
18q |
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What tumor is asc w/ HTLV-1?
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Adult T-cell leukemia
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What tumor is asc w/ HBV, HCV?
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Hepatocellular carcinoma
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What tumor is asc w/ EBV?
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Burkitt's lymphoma, nasopharyngeal carcinoma
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What tumor is asc w/ HPV?
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Cervical carcinoma (16, 18)
Penile/anal carcinoma |
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What tumor is asc w/ HHV8?
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Kaposi's sarcoma, body cavity fluid B-cell lymphoma
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What is a benign and malignant tumor of the epithelium called?
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B = adenoma, papillolma
M = adenocarcinoma, papillary carcinoma |
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What is a benign and malignant tumor of blood vessels?
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B = hemangioma
M = angiosarcoma |
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What is a benign and malignant tumor of smooth muscle?
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B = leiomyoma
M = leiomyosarcoma |
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What is a benign and malignant tumor of skeletal muscle?
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B = rhabdomyoma
M = rhadbomyosarcoma |
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What is a benign and malignant tumor of bone?
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B = osteoma
M = osteosarcoma |
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What is a benign and malignant tumor of fat?
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B = lipoma
M = liposarcoma |
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What is a benign and malignant tumor of >1 cell type?
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B = mature teratoma (women)
M = immature teratoma and mature teratoma (men) |
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What dz is ALL asc w/?
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Down syndrome
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What dz is melanoma, basal cell carcinoma and squamous cell carcinoma asc w/?
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Xeroderma pigmentosum
Albinism |
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What dz is gastric adenocarcinoma asc w/?
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Chronic atrophic gastritis, pernicious anemia, postsurgical gastric remnants
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What dz is astrocytoma, agiomyolipoma and cardiac rhabdomyoma asc w/?
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Tuberous sclerosis
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What dz is squamous cell carcinoma asc w/?
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actinic keratosis
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What dz is esophageal adenocarcinoma asc w/?
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Barrett's esophagus
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What dz is Squamous cell carcinoma of esophagus asc w/?
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Plummer-Vinson syndrome
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What dz is hepatocellular carcinoma asc w/?
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Cirrhosis
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What dz is colonic adenocarcinoma asc w/?
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ulcerative colitis
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What dz is 2o osteosarcoma and fibrosarcoma asc w/?
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Paget's dz
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What dz is aggressive malignant lymphomas asc w/?
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AIDS
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What dz is benign and malignant lymphomas asc w/?
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Autoimmune dz
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What dz is visceral malignancy (stomach, lung, breast, uterus) asc w/?
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Acanthosis nigricans
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What dz is malignant melanoma asc w/?
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Dysplastic nevus
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What dz is sarcoma asc w/?
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Radiation exposure
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What does tumor grade mean and how is it measured?
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Degree of cellular differentiation based on histo appearance
Graded from I-IV - degree of differentiation, # of mitosis/HPF |
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What does tumor stage mean and how is it measured?
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Degree of localization/spread
T = size of tumor N = node involvement M = mets *Prognosis: T > N > M |
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What is a mixed tumor and where is the most common location to encounter one?
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2 histologic tissue types but derived from 1 cell type
parotid gland |
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Where to carcinomas tend to met to ?
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regional lymph nodes (subsapsular sinus) - - > blood
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Where to sarcomas tend to met to?
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blood
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What is PSA a marker for?
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prostate-specific Ag
Used to screen for prostate carcinoma |
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What tumor is prostatic acid phosphatase a marker for?
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Prostate carcinoma
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What tumor is CEA a marker for?
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Carcinoembryonic Ag...nonspecific but produced by 70% of colorectal and pancreatic ca (as well as gastric and breat)
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What tumor is a-fetoprotin a marker for?
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Hepatocellular carcinoma
Nonseminomatous germ cell tumors of testis (yolk sac tumors) |
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What tumor is B-hCG a marker for?
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Hydatidiform moles
Choriocarcinomas Gestational trophoblastic tumors |
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What tumor is CA-125 a marker for?
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Ovarian
Malignant epi tumors |
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What tumor is S100 a marker for?
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Melanoma
Neural tumors Astrocytoma |
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What tumor is alk phos a marker for?
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Mets to bone
Obstructive biliary dz Page'ts dz of bone |
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What tumor is bombesin a marker for?
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Neuroblastoma
Lung Gastric ca |
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What tumor is CA-19-9 a marker for?
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Pancreatic adenocarcinoma
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What organ/tumor is affected by aflotoxins?
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liver (hepatocellular carcinoma)
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What organ/tumor is affected by vinyl chloride?
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Liver (angiosarcoma)
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What organ/tumor is affected by CCl4?
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Liver (centrilobular necrosis, fatty change)
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What organ/tumor is affected by Nitrosamines (smoke foods)?
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Estophagus
Stomach |
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What organ/tumor is affected by Cigarette smoke?
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Larynx
lung renal cell carcinoma transitional cell carcinoma |
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What organ/tumor is affected by asbestos?
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lung (mesothelioma and bronchogenic carcinoma)
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What organ/tumor is affected by arsenic?
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Skin (squamous cell carcinoma)
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What organ/tumor is affected by Naphthalene (aniline) dyes)
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bladder (transitional cell carcinoma)
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What organ/tumor is affected by Alkylating agents?
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Blood (leukemia)
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What paraneoplastic syndrome is produced by small cell lung carcinomas?
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ACTH or ACTH-like peptide
--> Cushing's syndrome |
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What paraneoplastic syndrome is produced by small cell lung carcinoma and intracranial neoplasms?
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ADH
--> SIADH |
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What paraneoplastic syndrome is produced by squamous cell carcinoma, renal cell carcinoma, and breast carcinoma?
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PTH-related peptide, TGFB, TNF, IL-1
--> hypercalcemia |
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What paraneoplastic syndrome is produced by renal cell carcinoma and hemangioblastoma?
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Erythropoiten
--> polycythemia |
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What paraneoplastic syndrome is produced by thymoma, small cell lung carcinoma?
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Ab against presynaptic Ca channels at NMJ
--> Lambert-Eaton syndrome |
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What paraneoplastic syndrome is produced by leukemias and lymphomas?
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Hyperuricemia due to excess nucleic acid turnover
--> Gout, urate nephropathy |
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What is a psammoma bodies and where are they found?
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Laminated, concentric, calcific spherules
PSaMMoma: Papillary adenocarcinoma of thyroid Serous papillary cystadenocarcinoma of ovary Meningioma Malignant mesothelioma |
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What tumor met to the brain?
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Lots of Bad Stuff Kills Glia
Lung, Breast, Skin (melanoma), Kidney (renal cell), GI |
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How do tumor mets to the brain appear?
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Multiple, well-circumscribed tumors at gray-white border
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What tumors met to the liver?
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Cancer Sometimes Penetrates Benign Liver
Colon > Stomach > Pancreas > Breast > Lung |
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What tumors met to the bone?
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P.T. Barnum Loves Kids
Prostate, Thyroid, Testes, Breast, Lung and Kidney Breast and prostate most common |
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What bone mets are lytic and blastic?
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Lung = lytic
prostate = blastic breast = both |
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What are the top three cancers in men?
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Prostate > Lung > Colorectal
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What are the top three cancers in women?
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Breast > Lung > colorectal
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What are the top two cancer killers in men?
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Lung > Prostate
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What are the top two cancer killers in women?
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Lung > Breast
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What node is Virchow's node and what does it signify?
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L. supraclavicular
stomach mets |
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What are the three most common GYN tumors?
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endometrial > ovarian > cervical
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What are the most common GYN cancer killers?
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ovarian > cervical > endometrial
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