• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/149

Click to flip

149 Cards in this Set

  • Front
  • Back
asperginase
AE- pancreatitis
lomustine, carmustine
crosses BBB, used for glioma
charcoal
AD for all other positings
vit K
AD for warfarn
atropine+pralidoxime
organophohphates , ACH2 inhibitors AD
Deforoxamine
AD for iron and salts
digoxin immun Fab
AD for digoxin
Dimercaprol
AD for Arshenic, gold, mercury, lead, oral succimer for milder lead and milder mercury toxicity
EDTA
AD for Cd, Cr, Co, Mn, Zn toxicity
Esmolol
AD for theyophyline, beta agonsits
Ethanol, fomepizole
AD for methoanol or ethylene glycol
flumanezil
AD for benzo
naloxone
AD for opoids
100% oxygen
AD for CO
pencillamine
AD for Cu
protamine
AD for Heparin
acetylcysteine
AD for acetaminophn
gingki
intermittent claudication and alzeimers, use in cuation with anticoags
saw palmetto
tx of BPH, 5 alpha reductase inhibitor and androgen receptor antagonist
St johns
serotonin syndrome, enhaces 5HT, interaction with antidepresants
abciximab
antagonist of IIb/IIIa receptors
infliximab
RA and CD , binds to TNF
trastuzumab
breast CA, ERB2(Her 2/neu)
rituximab
NHL, binds to surface protein
Interferon alpha
Hep B, C, lukemia, melanoma
Interferon beta
MS
Interferon gamma
CGD increases TNF
azithioprine
immunosupressant converted to 6- mercaptourine
cyclosporine
DOC for organ or tissue transplant , binds to cycophilin
Tacrolimus
alt to cylosporine , MOA- FK binding protein
alendronate
DOC for glucocroticoid induced ostoporosis
bisphonates
stabilzies hydroapatite, ends in ronate, for paget disease
teriparatide
recombinant DNA PTH analog, once daily, AE- continuous infusion stimulate osteoclast activity , increased risk of osteosarcoma
octreotide
somatostatin
somatropin
GH
cosyntropin
ACTH
leuprolide, nafarelin
GnRH
Propylthiouracil and methomazole
hyperthyroidism, PTU safer in pregnancy , inhibts oxidation, coupling, iodination, conversion of T3 to T 4
Flutamide
androgen receptor blocker for prostate CA
Leuprollide
GnRH analog, androgen receptor+ prostate cancer
Finasteride
5 alpha reductase inhibitor, USE- BPH and male pattern baldness
OCPs
increased risk of liver adenoma, complication- retroperitoneal bleeding
oxandrolone, nandrolone
androgens, male hypogonadism, use in atheles, AE- aggresion and cholestatic jaundice
norethindone
progestin, AE- hursuitisim
Raloxifene
no increased risk of endometrial cancer
clomiphene
fertility pill, decreases feedback inhnition, AE- multile births
Anastrazole
post menopausla breast CA
mifepristone
morning after pill, blocks glucocorticoid and progestin receptors
metyrapone, ketoconazole
blocks 11 hydroxylation
Exenatide
releases incretin, increases insulin secretion, GLP1 full agonist,
Sitagliptin
inhibits dipeptidyl peptidase, inhibits activaiton of GLP-1
pramilintide
synthetic version of amylin- slows rate of food absorption and decreases appetite
Pioglytazone and rosiglitazone
binds to PPAR increases sensitixation to isulin on genetic level, AE- less hypoglycemia than sufonynureas, wt gain, edema
acarbose
inhibits alpha glucosidase in brush borders of small intestince-->decreased absoprtion, AE- hepatoxic
metformin
increases tissue snesitivty to insulin and decreases hepatic gluconeogenesis, AE- lactic acidosis
repaglinide
stimuates insulin release from pancreatic beta cells
Acetohexamide, tolubutamide, chlorpromide
first generation sulfonylureas, chlorpomide(SIADH/disulfiram rxn)
glipizide, glyburide
second gen sulfonylureas
sulfonylureas
block K channles-->depolariozation-->insulin rlease, AE- hypoglycemia and wt gain, lots of DI(cimetidien, saliclylates, sulfonamides)
hypoglycema rxn
lip tonging, lethargy, confusion, sweats, tremors, coma, seizure
glargine
insulin analog with no peak
Abicimab, eptifibatide, tirofiban
Iib/IIIa antagonist, used for acute coronary syndrome (antiplatelet)
ticlopidine and clopidogrel
block ADP receptors on platelets, decreased activation (antiplatelet)
aspirin
prophylaxis for atrial arrthmias and TIAs, COX inh
streptokinase
thrombolytic, depetes circulating V and VIII
altepllase
trhomolytic clot specific
argatroban
used in HIT , direct thormbin inhibitors
Dabigatran
atrial fib
Bivalurudin
unstable angina
Warfarn
small, vit K deriv, oral, decreases hep syn of vit K factors, PT, fresh forozen plasma or vit K as tx, long term,AE- skin necrosis
Heparin
large, parenteral, PTT, tx- protamine sulfate, rapid, AE- HIT hypersensitivity
Theophylline
inhibits adenosine(prevents bronchoconstriction) and decreases PDE which increase cAMP and lead to bronchodilation
ipratropium
DOC for B blocker bronchospasm
cromolyn and nedocromil
prevents degran of pul mast cells and decreases release of histamine
lukasts
LTD4 antagonists, astham prophylactic
acute astham tx
B agonsits, theophylline
chronic astham tx
ipratropum, lukasts, zilueton
zileuton
selective LOX inhibitor
bexametasone, dexamethasone
glucocorticoids, decreases PGs and LTs, antiinf and immunisupression, AE- iatrogenic cushingoind syn, cortical atrophy, osteoporosis, electolyte imbalance
colchicine
binds to tubulie and decreases microtubular polyerzaiton
sulindac
NSAID with no renal effect, used for gout
allpurinol
prodrug that is converted by xanthine oxidase inhibits enzyme, decreases purine metablism decreases uric acid , AE- hypoxanthine stones, DI- inhinits 6-Mercaptopurine, used for chonic gout
probenecid
inhibits proximal tubular reabsorption of urate
acute gout
colchicine, NSAID, intracrutcalr steroids( cochilicine has lots of AE)
hydroxychloriquine
stabilizes lysosomes and decreases cehmostaxis, hemolysis in G6PD pts, used for RA
Methotrexate
cytotxoci to lymphocytes, hematoxicity
sulfasalazine
hemolysis in G6PD, for RA
RA drugs
hydroxychloruine, methotrexate, suflasalazine, glucocorticoids, gold salts, pencillamine, leflunamide, etanercept, inflixmab
glucocortioics
AE- cushoid syndrome, used for RA
gold salts
RA, AE- dermatatitis, hematoxicity, nephrotici
pencillamine
wilsons idsease, RA
leflunomide
inhibts DHOD, AE- alomeida, USE- RA
etanercept
binds TNF, infections, RA
anaakinra
IL1 receptor antagonist
RA drugs
NSAID initially(do not affect progresion just pain and inf) then put on DMARDs
metroniddazole
amebiasis, giardiasis, trichomoniasis, toxoplasmosis, leishmaniasis, trypanosomiasis
antimalarial prophylaixs
chloroquinine +primiquine( p vivax and povale)
leisbmaniasis
stibogluconate
trypnosmoasis
african(arsenicals) and nifurtomox(chagas disease)
chloroquin resistant mamalira
prophylkaxis- mefloquine, tx- quinine, AE- hemolytic anemia
mebendazole
nematodes , decreased glucose uptake and microtubular structure
praziquantel
tapeworms and flukes , increased Ca and increased vaculoization
pyratel pamoate
spastic paralysis
diphenhydramine
muscarnic blocker, sedatibe, antimotion
antihustamines
most block M receptors, are sedative and are antimition
loratidine and fexofenadie
antihismatines with NO CNS entry, no sedation and not anti mition sickess
H1 actication
capilalary dilation, increased permanility, decreased AV conduction
H2 activation
increased gastric acid secretion, increased SA node rate
cimetidine and ranitidine
H2 antagonists, supresses secretory resposnes to food, USE- PUD, GERD, ZE syndrome
cimetidine
H2 antaognist, CYP inh, gynecomastia and decreased libido
omeprazole
PPI, irreversible
misoprostol
PGE1 analog, increased mucus and bicarb secretion, decreased HCl secretion, NSAID induced ulcers, CI in pregnacy
sucralfate
protective gel like coating, antacids will interfere
bismuth subsalicylate
binds selectively to ulcer, coating and protecting it from acid and pepsin, BMT regimen
AlOH
antacid, constimation
MgOH
diarrhea
odansteron
5HT3 antagonist, antiemetic for chemo
antimetiec
5HT3 atnagaonsit, DA antagonist, H1 antagonist, muscarinic antagonsit, cabbinoids
apretipitant
NK receptor atntagonist, antiemetic
prochlorperazine, metoclopromide
DA antagonists , antiemetic
diphenhydramine, meclizine, promethazine
H1 antagonist , antiemetic
buspirone
partial agonsit at 5HT1a, GAD
sumatriptan
5HT1d decreases migraine pain
olanzapine
5HT2a antagonist, decreases symptoms of psychosis
cyproheptadine
5HT2 antagonist, used in carcinoid
ergotamine
partila agonist at alpha and 5HT2, vasoconstrctive, AE- abortion, gangene, ischemia
ergonovine
uterine smooth muscle contraction
carcinoid marker
5 HIAA- hydroxyindoleacetic acid
alrpostadil
mainatinas PDA, CI in pregnancy
dinoprostone
cervical rempening, abortifacient , PGE2
carboprost
PGF2alpha, abrotfacient
latanoprost
tx of glaucoma, decreased intraocular pressure
epoprostenol
PGI2, USE- pul HTN
aspirin
covalent bond via acetylation of a serine hyproxyl group near active site , antiplatetlet aggregiation- low dose, antiinfl- high dose, uncoupling of oxidative phosphryation, 0 order kinetics, alkanize urine , AE- reyes syndrome, angioedema, salycylism- vertigo, tinnitus, ringing,
celecoxib
cox 2 inhibitor , prothrombotic effects
acetaminophen
analgesic and antipyretic, hepatoxic, ethanol enhances liver toxicity , N acetylcysteine- antidote
doxarubicin and donarubicin
intercalate DNA and interfere with top II
cisplatin
binds to FNA, causing distortion and malfunction
AZT
chain termination, prevents further replciation HIV drug
quinilones
prevent DNA relciations and in hibits top II
rifampind
inhits prokaryotic RNA polymerase
Actinomycin D
inhibits DNA and RNA pol
chlorampehnicol
inhbits peptidyl transferase and inhibits translation in elognation step at 30S
macrolides
inbhits elongation step of translation
aminoglycosies
inhibts initiation by binding to 30S
tetracycline
inhibits elongation in translation step, binds to A site
fibrates and thiazolidendioens
use PPAR inrder to umpregulate insulin receptors which works through zinc fingers
gemfibrozil
stimualtes proliferation of peroxisomes and increased gene expresion of liporotein lipase