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149 Cards in this Set
- Front
- Back
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asperginase
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AE- pancreatitis
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lomustine, carmustine
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crosses BBB, used for glioma
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charcoal
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AD for all other positings
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vit K
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AD for warfarn
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atropine+pralidoxime
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organophohphates , ACH2 inhibitors AD
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Deforoxamine
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AD for iron and salts
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digoxin immun Fab
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AD for digoxin
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Dimercaprol
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AD for Arshenic, gold, mercury, lead, oral succimer for milder lead and milder mercury toxicity
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EDTA
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AD for Cd, Cr, Co, Mn, Zn toxicity
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Esmolol
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AD for theyophyline, beta agonsits
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Ethanol, fomepizole
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AD for methoanol or ethylene glycol
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flumanezil
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AD for benzo
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naloxone
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AD for opoids
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100% oxygen
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AD for CO
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pencillamine
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AD for Cu
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protamine
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AD for Heparin
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acetylcysteine
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AD for acetaminophn
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gingki
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intermittent claudication and alzeimers, use in cuation with anticoags
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saw palmetto
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tx of BPH, 5 alpha reductase inhibitor and androgen receptor antagonist
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St johns
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serotonin syndrome, enhaces 5HT, interaction with antidepresants
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abciximab
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antagonist of IIb/IIIa receptors
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infliximab
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RA and CD , binds to TNF
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trastuzumab
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breast CA, ERB2(Her 2/neu)
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rituximab
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NHL, binds to surface protein
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Interferon alpha
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Hep B, C, lukemia, melanoma
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Interferon beta
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MS
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Interferon gamma
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CGD increases TNF
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azithioprine
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immunosupressant converted to 6- mercaptourine
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cyclosporine
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DOC for organ or tissue transplant , binds to cycophilin
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Tacrolimus
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alt to cylosporine , MOA- FK binding protein
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alendronate
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DOC for glucocroticoid induced ostoporosis
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bisphonates
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stabilzies hydroapatite, ends in ronate, for paget disease
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teriparatide
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recombinant DNA PTH analog, once daily, AE- continuous infusion stimulate osteoclast activity , increased risk of osteosarcoma
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octreotide
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somatostatin
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somatropin
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GH
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cosyntropin
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ACTH
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leuprolide, nafarelin
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GnRH
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Propylthiouracil and methomazole
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hyperthyroidism, PTU safer in pregnancy , inhibts oxidation, coupling, iodination, conversion of T3 to T 4
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Flutamide
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androgen receptor blocker for prostate CA
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Leuprollide
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GnRH analog, androgen receptor+ prostate cancer
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Finasteride
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5 alpha reductase inhibitor, USE- BPH and male pattern baldness
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OCPs
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increased risk of liver adenoma, complication- retroperitoneal bleeding
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oxandrolone, nandrolone
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androgens, male hypogonadism, use in atheles, AE- aggresion and cholestatic jaundice
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norethindone
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progestin, AE- hursuitisim
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Raloxifene
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no increased risk of endometrial cancer
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clomiphene
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fertility pill, decreases feedback inhnition, AE- multile births
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Anastrazole
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post menopausla breast CA
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mifepristone
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morning after pill, blocks glucocorticoid and progestin receptors
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metyrapone, ketoconazole
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blocks 11 hydroxylation
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Exenatide
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releases incretin, increases insulin secretion, GLP1 full agonist,
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Sitagliptin
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inhibits dipeptidyl peptidase, inhibits activaiton of GLP-1
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pramilintide
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synthetic version of amylin- slows rate of food absorption and decreases appetite
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Pioglytazone and rosiglitazone
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binds to PPAR increases sensitixation to isulin on genetic level, AE- less hypoglycemia than sufonynureas, wt gain, edema
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acarbose
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inhibits alpha glucosidase in brush borders of small intestince-->decreased absoprtion, AE- hepatoxic
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metformin
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increases tissue snesitivty to insulin and decreases hepatic gluconeogenesis, AE- lactic acidosis
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repaglinide
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stimuates insulin release from pancreatic beta cells
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Acetohexamide, tolubutamide, chlorpromide
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first generation sulfonylureas, chlorpomide(SIADH/disulfiram rxn)
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glipizide, glyburide
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second gen sulfonylureas
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sulfonylureas
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block K channles-->depolariozation-->insulin rlease, AE- hypoglycemia and wt gain, lots of DI(cimetidien, saliclylates, sulfonamides)
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hypoglycema rxn
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lip tonging, lethargy, confusion, sweats, tremors, coma, seizure
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glargine
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insulin analog with no peak
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Abicimab, eptifibatide, tirofiban
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Iib/IIIa antagonist, used for acute coronary syndrome (antiplatelet)
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ticlopidine and clopidogrel
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block ADP receptors on platelets, decreased activation (antiplatelet)
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aspirin
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prophylaxis for atrial arrthmias and TIAs, COX inh
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streptokinase
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thrombolytic, depetes circulating V and VIII
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altepllase
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trhomolytic clot specific
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argatroban
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used in HIT , direct thormbin inhibitors
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Dabigatran
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atrial fib
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Bivalurudin
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unstable angina
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Warfarn
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small, vit K deriv, oral, decreases hep syn of vit K factors, PT, fresh forozen plasma or vit K as tx, long term,AE- skin necrosis
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Heparin
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large, parenteral, PTT, tx- protamine sulfate, rapid, AE- HIT hypersensitivity
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Theophylline
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inhibits adenosine(prevents bronchoconstriction) and decreases PDE which increase cAMP and lead to bronchodilation
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ipratropium
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DOC for B blocker bronchospasm
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cromolyn and nedocromil
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prevents degran of pul mast cells and decreases release of histamine
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lukasts
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LTD4 antagonists, astham prophylactic
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acute astham tx
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B agonsits, theophylline
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chronic astham tx
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ipratropum, lukasts, zilueton
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zileuton
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selective LOX inhibitor
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bexametasone, dexamethasone
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glucocorticoids, decreases PGs and LTs, antiinf and immunisupression, AE- iatrogenic cushingoind syn, cortical atrophy, osteoporosis, electolyte imbalance
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colchicine
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binds to tubulie and decreases microtubular polyerzaiton
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sulindac
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NSAID with no renal effect, used for gout
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allpurinol
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prodrug that is converted by xanthine oxidase inhibits enzyme, decreases purine metablism decreases uric acid , AE- hypoxanthine stones, DI- inhinits 6-Mercaptopurine, used for chonic gout
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probenecid
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inhibits proximal tubular reabsorption of urate
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acute gout
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colchicine, NSAID, intracrutcalr steroids( cochilicine has lots of AE)
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hydroxychloriquine
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stabilizes lysosomes and decreases cehmostaxis, hemolysis in G6PD pts, used for RA
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Methotrexate
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cytotxoci to lymphocytes, hematoxicity
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sulfasalazine
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hemolysis in G6PD, for RA
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RA drugs
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hydroxychloruine, methotrexate, suflasalazine, glucocorticoids, gold salts, pencillamine, leflunamide, etanercept, inflixmab
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glucocortioics
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AE- cushoid syndrome, used for RA
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gold salts
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RA, AE- dermatatitis, hematoxicity, nephrotici
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pencillamine
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wilsons idsease, RA
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leflunomide
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inhibts DHOD, AE- alomeida, USE- RA
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etanercept
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binds TNF, infections, RA
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anaakinra
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IL1 receptor antagonist
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RA drugs
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NSAID initially(do not affect progresion just pain and inf) then put on DMARDs
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metroniddazole
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amebiasis, giardiasis, trichomoniasis, toxoplasmosis, leishmaniasis, trypanosomiasis
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antimalarial prophylaixs
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chloroquinine +primiquine( p vivax and povale)
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leisbmaniasis
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stibogluconate
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trypnosmoasis
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african(arsenicals) and nifurtomox(chagas disease)
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chloroquin resistant mamalira
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prophylkaxis- mefloquine, tx- quinine, AE- hemolytic anemia
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mebendazole
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nematodes , decreased glucose uptake and microtubular structure
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praziquantel
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tapeworms and flukes , increased Ca and increased vaculoization
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pyratel pamoate
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spastic paralysis
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diphenhydramine
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muscarnic blocker, sedatibe, antimotion
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antihustamines
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most block M receptors, are sedative and are antimition
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loratidine and fexofenadie
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antihismatines with NO CNS entry, no sedation and not anti mition sickess
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H1 actication
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capilalary dilation, increased permanility, decreased AV conduction
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H2 activation
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increased gastric acid secretion, increased SA node rate
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cimetidine and ranitidine
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H2 antagonists, supresses secretory resposnes to food, USE- PUD, GERD, ZE syndrome
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cimetidine
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H2 antaognist, CYP inh, gynecomastia and decreased libido
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omeprazole
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PPI, irreversible
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misoprostol
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PGE1 analog, increased mucus and bicarb secretion, decreased HCl secretion, NSAID induced ulcers, CI in pregnacy
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sucralfate
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protective gel like coating, antacids will interfere
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bismuth subsalicylate
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binds selectively to ulcer, coating and protecting it from acid and pepsin, BMT regimen
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AlOH
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antacid, constimation
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MgOH
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diarrhea
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odansteron
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5HT3 antagonist, antiemetic for chemo
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antimetiec
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5HT3 atnagaonsit, DA antagonist, H1 antagonist, muscarinic antagonsit, cabbinoids
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apretipitant
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NK receptor atntagonist, antiemetic
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prochlorperazine, metoclopromide
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DA antagonists , antiemetic
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diphenhydramine, meclizine, promethazine
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H1 antagonist , antiemetic
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buspirone
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partial agonsit at 5HT1a, GAD
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sumatriptan
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5HT1d decreases migraine pain
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olanzapine
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5HT2a antagonist, decreases symptoms of psychosis
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cyproheptadine
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5HT2 antagonist, used in carcinoid
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ergotamine
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partila agonist at alpha and 5HT2, vasoconstrctive, AE- abortion, gangene, ischemia
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ergonovine
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uterine smooth muscle contraction
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carcinoid marker
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5 HIAA- hydroxyindoleacetic acid
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alrpostadil
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mainatinas PDA, CI in pregnancy
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dinoprostone
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cervical rempening, abortifacient , PGE2
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carboprost
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PGF2alpha, abrotfacient
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latanoprost
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tx of glaucoma, decreased intraocular pressure
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epoprostenol
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PGI2, USE- pul HTN
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aspirin
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covalent bond via acetylation of a serine hyproxyl group near active site , antiplatetlet aggregiation- low dose, antiinfl- high dose, uncoupling of oxidative phosphryation, 0 order kinetics, alkanize urine , AE- reyes syndrome, angioedema, salycylism- vertigo, tinnitus, ringing,
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celecoxib
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cox 2 inhibitor , prothrombotic effects
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acetaminophen
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analgesic and antipyretic, hepatoxic, ethanol enhances liver toxicity , N acetylcysteine- antidote
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doxarubicin and donarubicin
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intercalate DNA and interfere with top II
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cisplatin
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binds to FNA, causing distortion and malfunction
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AZT
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chain termination, prevents further replciation HIV drug
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quinilones
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prevent DNA relciations and in hibits top II
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rifampind
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inhits prokaryotic RNA polymerase
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Actinomycin D
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inhibits DNA and RNA pol
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chlorampehnicol
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inhbits peptidyl transferase and inhibits translation in elognation step at 30S
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macrolides
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inbhits elongation step of translation
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aminoglycosies
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inhibts initiation by binding to 30S
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tetracycline
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inhibits elongation in translation step, binds to A site
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fibrates and thiazolidendioens
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use PPAR inrder to umpregulate insulin receptors which works through zinc fingers
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gemfibrozil
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stimualtes proliferation of peroxisomes and increased gene expresion of liporotein lipase
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