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56 Cards in this Set

  • Front
  • Back
Autoimmune disease that can lead to:
Parotid gland enlargement
Dental Caries
Recurrent Tracheobronchitis
Sjogren's syndrome
Transfer of tissue between genetically identical individuals (identical twins)
Syngeneic graft
Graft b/w genetically different members of the same species
Allograft or Homograft
Transfer of an individuals own tissue to his own body
Transfer of tissue between different species
Xenograft (Heterograft)
Anti-centromere antibody autoimmune disease
CREST syndrome / Systemic Sclerosis
Anti-histone Ab's auto-disease
Drug-induced lupus
Celiac Disease
Hashimoto's thyroiditis
Anti-mitochondrial Ab
primary biliary cirrhosis
Anti-SS-A and B
Sjogren's Syndrome
IL secreted by Th1 cells that stimulates NK, CD8+ T cells

Downregulates Th2 cells
IL secreted by Macrophages that induces inflammation
IL secreted from Th2 cells which downregulates Th1 cells and promotes class switching to IgE
IL secreted by MO which stimulates Acute Phase protein production by the liver as well as Plasma cell formation
IL secreted by macrophages that is the major chemotactic molecule for neutrophils
Ig marker type that is helpful in paternity testing
-kappa and gamma light chains
Type of Ig's that have been produced in response to specific antigens
Ig epitope class that make up the 5 classes of Ig
Immune mechanism the body employs against live Filarial worms
Antibody-dependent cell-mediated cytotoxicity using IgE
Immune deficiency due to any of these: IL-2 receptor, Adenosine deaminase, or MHC-II deficiency
Severe Combined Immunodeficiency (SCID)
Susceptible to Staphylococcus infections due to NADPH Oxidase deficiency in Neutrophils
Chronic Granulomatous Disease
Diagnosis of this immune deficiency is confirmed with negative nitroblue tetrazolium dye reduction test
Chronic granulomatous disease
Immunodeficiency characterized by:
Recurrent pyogenic infections
Wiscott-Aldrich syndrome
X-linked Immunodeficiency associated with:
-high IgA levels
-normal IgE levels
-low IgM levels (= no response to capsular polysaccharides of bacteria)
Wiskott-Aldrich syndrome
-Swollen and painful toes and knees (Dactylitis)
-Low back pain
Reiter's syndrome
What does the HIV ELISA test detect?
p24 antibody
Anti-DNA topoisomerase I
Systemic Sclerosis

= anti-Scl-70
-Hypocalcemia resulting in muscle spasms (tetany)
-Recurrent infections
-Neonatal seizures

What Syndrome?
What pathogens are they susceptible to?
DiGeorge syndrome

Cell mediated immunity
-Fungal infection
Immune response against Exotoxins
HLA haplotyes asociated with SLE

HLA-B27 is associated with what 4 diseases?
Ankylosing spondylitis
Reiter's syndrome

Form of chronic inflammation of the spine and the sacroiliac joints
Ankylosing spondylitis
Disease associated with HLA-DR3 and HLA-DR4
Type I Diabetes
Disease associated with HLA-DR4
Rheumatoid arthritis
Patient is given an appropriately matched ABO and Rh type blood transfusion but becomes rapidly hypotensive and develops airway edema.

What pre-existing condition accounts for these symptoms?
Selective IgA deficiency
-anti-IgA Ab's are reacting with the transfused IgA's
Low levels of all Ig's

1. What disease?
2. What protein deficiency is related to the condition?
1. Bruton's X-linked agammaglobulinemia

2. Tyrosine kinase
Postvaccinial lymphadenitis showing MNGC's with eosinophilic cytoplasmic and nuclear inclusion bodies

What vaccine?
-Warthin-Finkeldey giant cells
HLA associated with Lyme Disease oligoarticular arthritis
Anti-mitochondrial Ab's
Primary Biliary Cirrhosis
Autoantibody directed against the Fc portion of IgG
Rheumatoid Factor
Auto-antibodies to the Acetycholine receptor syndrome
Myasthenia gravis
-double vision
Auto-antibodies to TSH receptor syndrome
Grave's Disease
What Ig genes are linked on a single chromosome?
Heavy chain genes
-IgG, M, E, D, A
Consequence of not treating Scleroderma?
Fatal systemic fibrosis
High levels of IgM
Low levels of IgA and IgG
Hyper-IgM syndrome
What causes Hyper-IgM syndrome?
defective CD40 ligand on T cell (not CD40 on B cell)
CD markers for B cells
CD 19
CD 20
CD 21
CD marker for NK cells
CD 16
CD 56
IL that is produced by Th2 cells and inhibits Th1 cells = promotes humoral response
IL produced by Macrophages that stimulates Th1 and CTL formation = CMI response

*acts with IL-2
Long-term sequela of Rheumatic fever
Mitral valve disease

*Arthritis is transitory
Where is IgA produced?
Plasma cells in the Lamina Propria of the GI and Respiratory Tracts
Goodpasture's syndrome associated HLA

*Type 3 HS reaction
HLA associated with Steroid responsive Nephrotic Syndrome
HLA associated with Pernicious Anemia and Juvenile Rheumatoid Arthritis