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56 Cards in this Set
- Front
- Back
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Autoimmune disease that can lead to:
Parotid gland enlargement Dental Caries Recurrent Tracheobronchitis |
Sjogren's syndrome
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Transfer of tissue between genetically identical individuals (identical twins)
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Syngeneic graft
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Graft b/w genetically different members of the same species
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Allograft or Homograft
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Transfer of an individuals own tissue to his own body
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Autograft
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Transfer of tissue between different species
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Xenograft (Heterograft)
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Anti-centromere antibody autoimmune disease
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CREST syndrome / Systemic Sclerosis
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Anti-histone Ab's auto-disease
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Drug-induced lupus
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Anti-gliadin
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Celiac Disease
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Anti-microsomal
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Hashimoto's thyroiditis
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Anti-mitochondrial Ab
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primary biliary cirrhosis
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Anti-SS-A and B
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Sjogren's Syndrome
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IL secreted by Th1 cells that stimulates NK, CD8+ T cells
Downregulates Th2 cells |
IL-2
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IL secreted by Macrophages that induces inflammation
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IL-1
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IL secreted from Th2 cells which downregulates Th1 cells and promotes class switching to IgE
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IL-4
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IL secreted by MO which stimulates Acute Phase protein production by the liver as well as Plasma cell formation
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IL-6
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IL secreted by macrophages that is the major chemotactic molecule for neutrophils
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IL-8
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Ig marker type that is helpful in paternity testing
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Allotype
-kappa and gamma light chains |
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Type of Ig's that have been produced in response to specific antigens
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Idiotypes
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Ig epitope class that make up the 5 classes of Ig
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Isotypes
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Immune mechanism the body employs against live Filarial worms
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Antibody-dependent cell-mediated cytotoxicity using IgE
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Immune deficiency due to any of these: IL-2 receptor, Adenosine deaminase, or MHC-II deficiency
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Severe Combined Immunodeficiency (SCID)
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Susceptible to Staphylococcus infections due to NADPH Oxidase deficiency in Neutrophils
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Chronic Granulomatous Disease
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Diagnosis of this immune deficiency is confirmed with negative nitroblue tetrazolium dye reduction test
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Chronic granulomatous disease
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Immunodeficiency characterized by:
Thrombocytopenia Eczema Recurrent pyogenic infections |
Wiscott-Aldrich syndrome
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X-linked Immunodeficiency associated with:
-high IgA levels -normal IgE levels -low IgM levels (= no response to capsular polysaccharides of bacteria) |
Wiskott-Aldrich syndrome
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-Swollen and painful toes and knees (Dactylitis)
-Low back pain -Conjunctivitis |
Reiter's syndrome
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What does the HIV ELISA test detect?
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p24 antibody
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Anti-DNA topoisomerase I
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Systemic Sclerosis
= anti-Scl-70 |
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-Hypocalcemia resulting in muscle spasms (tetany)
-Recurrent infections -Neonatal seizures What Syndrome? What pathogens are they susceptible to? |
DiGeorge syndrome
Cell mediated immunity -Viruses -Fungal infection -Mycobacteria |
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Immune response against Exotoxins
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Antibodies
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HLA haplotyes asociated with SLE
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HLA-DR2
HLA-DR3 |
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HLA-B27 is associated with what 4 diseases?
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Psoriasis
Ankylosing spondylitis IBD Reiter's syndrome *PAIR* |
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Form of chronic inflammation of the spine and the sacroiliac joints
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Ankylosing spondylitis
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Disease associated with HLA-DR3 and HLA-DR4
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Type I Diabetes
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Disease associated with HLA-DR4
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Rheumatoid arthritis
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Patient is given an appropriately matched ABO and Rh type blood transfusion but becomes rapidly hypotensive and develops airway edema.
What pre-existing condition accounts for these symptoms? |
Selective IgA deficiency
-anti-IgA Ab's are reacting with the transfused IgA's |
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Low levels of all Ig's
1. What disease? 2. What protein deficiency is related to the condition? |
1. Bruton's X-linked agammaglobulinemia
2. Tyrosine kinase |
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Postvaccinial lymphadenitis showing MNGC's with eosinophilic cytoplasmic and nuclear inclusion bodies
What vaccine? |
Measles
-Warthin-Finkeldey giant cells |
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HLA associated with Lyme Disease oligoarticular arthritis
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HLA-DR4
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Anti-mitochondrial Ab's
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Primary Biliary Cirrhosis
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Autoantibody directed against the Fc portion of IgG
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Rheumatoid Factor
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Auto-antibodies to the Acetycholine receptor syndrome
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Myasthenia gravis
-double vision -ptosis |
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Auto-antibodies to TSH receptor syndrome
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Grave's Disease
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What Ig genes are linked on a single chromosome?
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Heavy chain genes
-IgG, M, E, D, A |
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Consequence of not treating Scleroderma?
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Fatal systemic fibrosis
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High levels of IgM
Low levels of IgA and IgG |
Hyper-IgM syndrome
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What causes Hyper-IgM syndrome?
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defective CD40 ligand on T cell (not CD40 on B cell)
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CD markers for B cells
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CD 19
CD 20 CD 21 |
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CD marker for NK cells
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CD 16
CD 56 |
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IL that is produced by Th2 cells and inhibits Th1 cells = promotes humoral response
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IL-10
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IL produced by Macrophages that stimulates Th1 and CTL formation = CMI response
*acts with IL-2 |
IL-12
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Long-term sequela of Rheumatic fever
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Mitral valve disease
*Arthritis is transitory |
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Where is IgA produced?
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Plasma cells in the Lamina Propria of the GI and Respiratory Tracts
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Goodpasture's syndrome associated HLA
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DR3
*Type 3 HS reaction |
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HLA associated with Steroid responsive Nephrotic Syndrome
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DR7
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HLA associated with Pernicious Anemia and Juvenile Rheumatoid Arthritis
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DR5
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