Usmle Immunology General

Front 1

HLA subtypes associated with disease

HLA-A3

Back 1

Hemochromatosis

Front 2

HLA subtypes associated with disease

HLA- B27

Back 2

Psoriasis
Ankylosing spondylitis
Inflammatory bowel disease
Reiter's syndrome

Front 3

HLA subtypes associated with disease

HLA-B8

Back 3

Graves disease

Front 4

HLA subtypes associated with disease

HLA-DR2

Back 4

Multiple sclerosis
Hay fever
SLE
Goodpasture's

Front 5

HLA subtypes associated with disease

HLA-DR3

Back 5

Diabetes type 1

Front 6

HLA subtypes associated with disease

HLA-DR4

Back 6

Rhuematoid arthritis
Diabetes mellitus type 1

Front 7

HLA subtypes associated with disease

HLA-DR5

Back 7

Pericious anemia--> B12 deficiency
Hashimotos thyroidosis

Front 8

HLA subtypes associated with disease

HLA-DR7

Back 8

Steroid responsive nephrotic syndrome

Front 9

Immunoglobulin subtypes

IgG

Back 9

Main antibody in delayed response to antigen
FIxes complement
Crosses placenta
Opsonization
Neutralization

Front 10

Immunoglobulin subtypes

IgA

Back 10

Prevent attachment of bacteria and viruses to mucous membranes

Found in secretions

Front 11

Immunoglobulin subtypes

IgM

Back 11

Produced as the primary response to an antigen
Fixes complement
Antigen receptor on B cells

Front 12

Immunoglobulin subtypes

IgD

Back 12

Unclear function
Found on surface of B cells and in serum

Front 13

Immunoglobulin subtypes

IgE

Back 13

Binds mast cells and basophils
Mediates type 1 hypersensitivity
Activates eosinophils
Lowest concentration in serum

Front 14

Cytokines

IL-1

Back 14

Secreted by macrophages
Fever

Front 15

Cytokines

IL-2

Back 15

Secreted by Th
Stimulate T-cells

Front 16

Cytokines

IL-3

Back 16

Secreted by activated T-cells
Stimulates bone marrow growth (similar to GM-CSF)

Front 17

Cytokines

IL-4

Back 17

Secreted by Th-2
Class switching to IgE and IgG

Front 18

Cytokines

IL-5

Back 18

Secreted by Th-2
Class switching to IgA
Activation of eosinophils

Front 19

Cytokines

IL-6

Back 19

Secreted by Th cells and macrophages
Simulates release of Acute phase reactants and Immunoglobulins

Front 20

Cytokines

IL-8

Back 20

Secreted by macrophages
Major chemotactic factor for neutrophils
"clean up on aisle(IL) 8"

Front 21

Cytokines

IL-10

Back 21

Secreted by T-reg
Inhibits active T cells
Activates Th-2
Inhibits Th-1

Front 22

Cytokines

IL-12

Back 22

Secreted by B-cells and Macrophages
Activates NK and Th-1

Front 23

Cytokines

y-interferon

Back 23

Secreted by Th-1 cells
Stimulates Macrophages
Activates Th-1
Inhibits Th-2

Front 24

Cytokines

TNF

Back 24

Secreted by macrophages
Mediates septic shock
Leukocyte recruitment
Vascular leak

Front 25

Cell surface proteins

Helper T cells

Back 25

CD4
TCR
CD3
CD28
CD40L

Front 26

Cell surface proteins

Cytotoxic T cells

Back 26

CD8
TCR
CD3

Front 27

Cell surface proteins

B cells

Back 27

IgM
CD19
CD20
CD21(receptor for EBV)
CD40
MHC II
B7

Front 28

Cell surface proteins

Macrophages

Back 28

MHC II
B7
CD40
CD14
Receptors for Fc and C3b

Front 29

Cell surface proteins

NK cells

Back 29

Receptor for MHC I
CD16 (bindsFc of IgG)
CD56

Front 30

Cell surface proteins

All cells except mature red cells

Back 30

MHC I

Front 31

Granulomatous Diseases

Back 31

1) Tuberculosis
2) Fungal infections
3) Syphilis
4) Leprosy
5) Cat scratch fever
6) Sarcoidosis
7) Crohn's disease
8) Berylliosis

Front 32

Autoantibodies

Antinuclear antibodies (ANA)

Back 32

SLE

Front 33

Autoantibodies

Anti-ds DNA, anti-Smith

Back 33

Specific for SLE

Front 34

Autoantibodies

Antihistone

Back 34

Drug induced Lupus

Front 35

Autoantibodies

Anti-IgG (rheumatoid factor)

Back 35

Rheumatoid arthritis

Front 36

Autoantibodies

Anticentromere

Back 36

Scleroderma (CREST)

Front 37

Autoantibodies

Anti-Scl-70 (anti-DNA Topoisomerase I)

Back 37

Scleroderma (diffuse)

Front 38

Autoantibodies

Antimitochondrial

Back 38

Primary biliary cirrhosis

Front 39

Autoantibodies

Antigliadin, antiendomysial

Back 39

Celiac Disease

Front 40

Autoantibodies

Antibasement membrane

Back 40

Goodpasture's syndrome

Front 41

Autoantibodies

Anti-desmoglein

Back 41

Pemphigus vulgaris

Front 42

Autoantibodies

Antimicrosomal
Antithyroglobulin

Back 42

Hasimoto's thyroiditis

Front 43

Autoantibodies

Anti-Jo-1

Back 43

Polymyositis
Dermomyositis

Front 44

Autoantibodies

Anti-SS-A (anti-Ro)

Back 44

Sjorgren's syndrome

Front 45

Autoantibodies

Anti-SS-A (anti-La)

Back 45

Sjogren's syndrome

Front 46

Autoantibodies

Anti-U1 RNP (ribonucleoprotein)

Back 46

Mixed connective tissue disorder

Front 47

Autoantibodies

Anti-smooth muscle

Back 47

Autoimmune hepatitis

Front 48

Autoantibodies

Anti-glutamate decarboxylase

Back 48

Type 1 Diabetes mellitus

Front 49

Autoantibodies

c-ANCA

Back 49

Wegener's granulomatosis

Front 50

Autoantibodies

p-ANCA

Back 50

Other vasculitides