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5 Cards in this Set

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  • Back
Name TH2 Cytokines and their actions
IL-2 (also from TH1) -- Stimulates Tcell growth
IL-4 -- Bcell differentiation (switch to IgE)
IL-5 -- Bcell differentiation (switch to IgA)
IL-6 (also TH1&Macrophage) --Stimulates production of acute phase reactants and is a pyogen
IL-10 -- Stimulates TH2 and Inhibits TH1 (cellular immunity)
Name TH1 Cytokines and their actions
IL-2 (also from TH2) -- Stimulates Tcell growth
IL-6 (also TH2&Macrophage) --Stimulates production of acute phase reactants and is a pyogen
IFN-gamma -- Stimulates TH1, inhibits TH2
Name Macrophages' cytokines and their actions
IL-1 --Endogenous pyogen
IL-6 (also TH1&2) --Stimulates production of acute phase reactants and is a pyogen
IL-8 -- Major chemotactic factor for neutrophils
TNF-alpha --Leukocyte recruitment and vascular leakage (key in septic shock)
Name Bcells' cytokines and their actions
IL-12 (also by macrophages) --Activates Th1 and NK cells
Pneumonic for cytokines 1-5?
HOT T-Bone stEAk

IL-1 = fever (hot)
IL-2 = Tcell activator
IL-3 = Bone marrow stimulation (similar to GM-CSF)
IL-4 = activates switch to IgE
IL-5 = activates switch to IgA