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10 Cards in this Set

  • Front
  • Back
Which complement components recruit inflammatory cells
C3a, C4a, C5a
Which complement components opsonize pathogens
C3b
Which complement components clear immune complexes
C3b
Which complement components kill pathogens
C5b, C6, C7, C8, C9
(aka the Membrane Attack Complex "MAC")
How is MAC activated in
1. Classic pathway
2. Alternative pathway
1. IgG and/or IgM (GM makes classic cars)
2. Endotoxins on the surface of microbes
Which complement components are involved in anaphylaxis
C3a, C5a
Which complement components are involved in neutrophil chemotaxis
C5a
C3 deficiency means...
1. severe recurrent pyogenic sinus/respiratory infections
2. Inc. succeptibility to type III hypersensitivity (Ab-Ag complexes)
What keeps complement from attacking self cells?
Decay-accelerating factor (DAF) and C1 esterase inhibitor

Note: DAF deficiency leads to paroxysmal nocturnal dyspnea b/c of complement attack on RBCs
MAC is primary useful against
Gram - bacteria (especially Neisseria)