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10 Cards in this Set
- Front
- Back
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Which complement components recruit inflammatory cells
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C3a, C4a, C5a
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Which complement components opsonize pathogens
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C3b
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Which complement components clear immune complexes
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C3b
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Which complement components kill pathogens
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C5b, C6, C7, C8, C9
(aka the Membrane Attack Complex "MAC") |
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How is MAC activated in
1. Classic pathway 2. Alternative pathway |
1. IgG and/or IgM (GM makes classic cars)
2. Endotoxins on the surface of microbes |
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Which complement components are involved in anaphylaxis
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C3a, C5a
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Which complement components are involved in neutrophil chemotaxis
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C5a
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C3 deficiency means...
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1. severe recurrent pyogenic sinus/respiratory infections
2. Inc. succeptibility to type III hypersensitivity (Ab-Ag complexes) |
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What keeps complement from attacking self cells?
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Decay-accelerating factor (DAF) and C1 esterase inhibitor
Note: DAF deficiency leads to paroxysmal nocturnal dyspnea b/c of complement attack on RBCs |
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MAC is primary useful against
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Gram - bacteria (especially Neisseria)
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