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28 Cards in this Set
- Front
- Back
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Disease assoc w/ t(9,22)
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Philadelphia chromosome
CML (bcr-abl) |
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Disease assoc w/ t(8,14)
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Burkitt's lymphoma
(c-myc activation) |
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Disease assoc w/ t(14,18)
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Follicular lymphomas
(bcl-2 activation) |
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Disease assoc w/ t(15,17)
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M3 type of AML
responsive to all trans-retinoic acid |
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Disease assoc w/ t(11,22)
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Ewing's sarcoma
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Disease assoc w/ t(11,14)
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Mantle cell lymphoma
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What causes Histiocytosis X?
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Langerhans cells from the monocyte lineage that infiltrate the lung.
Birbeck granules - tennis rackets on EM Primarily affects young adults. Worse w/ smoking. |
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Cell-cycle specific chemotherapy drugs
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antimetabolites - MTX, 5-FU, 6-MP
etoposide bleomycin vinca alkaloids paclitaxel |
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Cell cycle non-specific chemotherapeutics
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Alkylating agents
Antibiotics (dactinomycin, doxorubicin) |
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Methotrexate
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Fx - S-phase antimetabolite, folic acid analog that inhibits DHFR, decreasing dTMP and protein synthesis
Toxicity - Myelosuppression (rescue w/ leucovorin, folinic acid), macrovesicular fatty change in liver, mucositis. |
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5-Fluorouracil
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S-phase specific anti-metabolite. pyrimidine analog that is activated and complexes folic acid and inhibits thymidylate synthase, resulting in decreased protein synthesis..
Toxicity - myelosuppression, rescue w/ thymidine. photosensitivity |
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6-Mercaptopurine
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Toxicity - Bone marrow, GI, liver. Metabolized by xanthine oxidase, increases toxicity w/ allopurinol.
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Cytarabine (ara-C)
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Toxicities:
Leukopenia Thrombocytopenia Megaloblastic anemia |
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Cyclophosphamide, ifosfamide
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Alkylating agents, cross-link DNA
Toxicities: Myelosuppression Hemorrhagic cystitis Prevent w/ mesna |
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Nitrosoureas
Carmustine, lomustine, semustine, streptozocin |
Alkylates DNA, crosses BBB
CNS toxicities - dizziness, ataxia |
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Cisplatin, carboplatin
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Toxicities:
Nerphrotoxicity Acoustic nerve damage |
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Busulfan
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Toxicities
Pulmonary fibrosis Hyperpigmentation |
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Doxorubicin (adriamycin), daunorubicin
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Cardiotoxicity
Myelosuppression Marked alopecia Toxic extravasation |
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Dactinomycin
(actinomycin D) |
Toxicity - myelosuppression
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Bleomycin
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Toxicity - bone marro
Suppression GI upset |
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Hydroxyurea
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Bone marrow suppression
GI upset |
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Etoposide VP-16 toxicity
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Myelosuppression
GI irritation Alopecia |
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Prednisone toxicity
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cushing-like symptoms
immunosuppression cataracts acne osteoporosis hypertension peptic ulcers hyperglycemia psychosis |
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Tamoxifen, raloxifene toxicity
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Tamoxifen may increase the risk of endometrial carcinoma via partial agonist effects - hot flashes.
Raloxifene does not cause endometrial carcinoma because it is an endometrial antagonist |
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Trastuzumab (Herceptin) toxicity
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Cardiotoxicity
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Imatinib toxicity
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Fluid retention
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Vincristine, vinblastine toxicity
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Vincristine - neurotoxicity (areflexia, peripheral neuritis), paralytic ileus
Vinblastine - bone marrow suppression |
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Paclitaxel, other taxol toxicities
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Myelosuppression
Hypersensitivity |
