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22 Cards in this Set
- Front
- Back
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Antipsychotics
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Haloperidol, trfluoperazine, fluphenazine, thioridazine, chlorpromazine
"-azines + haloperidol" |
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Antipsychotics
1. MOA 2. Uses 3. Tox |
1. Block D2 -> increased cAMP
2. Schizophrenia (for positive sx), psychosis, manic episodes, tourette's 3. Extrapyramidal effects (eg dyskinesia), endocrine - dopamine antagonism -> hyperprolactinemia. Neuroleptic malignant syndrome, tardive dyskinesia. Non-neuro side fx from blocking muscarinic, alpha-1, histamine. |
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High potency antipsychotics and main side effects
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Haloperidol, trifluoperazine, fluphenazine
(Try to Fly High). Mainly EPS sx |
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Low potency antipsychotics and side fx
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Chlorpromazine, thioridazine (Cheating Thieves and low).
Chlorprimazine - corneal deposits Thioridazine - retinal deposits |
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Atypical antipsychotics
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Olanzapine, clozapine, quetiapine, risperidone, aripiprazole, ziprasidone
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Atypical antipsychotics
1. MOA 2. Use 3. Side fx |
1. MOA - varied effects on receptors
2. Schizophrenia - positive and negative symptoms; bipolar, OCD, anxiety, depression, mania, Tourette's 3. Tox: Fewer EPS and anticholinergic effects than typicals |
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Side effects
Olanzapine Clozapine Ziprasidone |
Olanapine/clozapine - significant weight gain
Clozapine - agranulocytosis, seizures Ziprasidone - QT prolongation |
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Lithium
1. Use 2. Side effects |
Use - mood stabilizer for BP - prevents relapse and acute events; SIADH
Side effects - Tremor, hypothyroidism, polyuria (ADH antagonist -> nephrogenic DI) Teratogen - Ebstein anomaly, great vessel malformation. Note: reabsorbed in PCT, excreted in kidneys |
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Buspirone
1. MOA 2. Use |
1. 5HT1A agonist
2. GAD, does not interact with alcohol (unlike benzos or barbs) |
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SSRIs
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Fluoxetine, paroxetine, sertraline, citalopram
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SSRIs
1. MOA 2. Use 3. Side effects |
1. Come on.
2. Depression, GAD, panic disorder, OCD, bulimia, social phobias, PTSD 3. Sexual dysfunction Serotonin syndrome |
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Sx and treatment of serotonin syndrome
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Serotonin syndrome - hyperthermia, myoclonus, AMS, CV collapse, seizures, diarrhea, flushing.
Tx: Cyproheptadine (5-HT2) |
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SNRIs
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Venlafaxine, duloxetine
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SNRIs
1. MOA 2. Use 3. Side effects |
1. Duh
2. Depression Venlafaxine - GAD, panic disorders Duloxetine - diabetic peripheral neuropathy, greater effect on NE 3. Increased BP, stimulant effects |
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Tricyclics
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Lots
End in -iptyline or -ipramine except for doxepin and amoxapine |
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Tricyclics
1. MOA 2. Use 3. Side effects |
1. MOA - block NE and serotonin reuptake
2. Use - Depression, fibromyalgia Imipramine - bedwetting Clomipramine - OCD 3. Sedating, alpha-1 blocking -> postural HTN, atropine-like effects (anticholinergic) - tachycardia, urinary retention, dry mouth Tertiary TCA (amitryptaline) have more anticholinergic fx than secondary (nortryptyline). Desipramine - less sedating, lower seizure threshold Convulsions, Coma, Cardiotox (arrythmias) Use NaHCO3 for cardiovascular tox Anticholinergic effects -> confusion, hallucinations in elderly |
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MAOi
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Tranylcypromine, phenelzine, isocarboxazid, selegiline (selective MAO-B)
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MAOi
1. MOA 2. Use 3. Side effects |
1. Increased levels of amine NTs (NE, serotonin, dopamine)
2. Atypical depression, anxiety, hypochondriasis 3. HTN crisis particularly when eating tyramines (cheeses, wine), CNS stimulation. C/I SSRIs, TCAs, St. John's Wort, meperidine, dextromethorphan |
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Bupropion
1. MOA 2. Use 3. Side effects |
1. Increases NE and dopamine
2. Depression, smoking cessation 3. Stimulant effects, seizure in bulimic patients. NO sexual side effects |
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Mirtazapine
1. MOA 2. Use 3. Side effects |
1. a2-antagonist (increase release of NE and serotonin) and 5HT2/3 antagonist.
2. Depression 3. Sedation, inc appetite, weight gain, dry mouth |
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Maprotiline
1. MOA 2. Use 3. Side effects |
1. Blocks NE reuptake
2. Depression 3. Sedation, orthostatic hypotension |
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Trazodone
1. MOA 2. Use 3. Side effects |
1. Inhibits serotonin reuptake
2. Insomnia, high doses for depression 3. Sedation, priapism (C/I in adolescent boys), postural hypotension |
