Usmle Fa Immunology Bateman

Front 1

lymphatic drainage of rectum and anal canal above pectinate line

Back 1

internal iliac

Front 2

lymphatic drainage of anal canal below pectinate line

Back 2

superficial inguinal

Front 3

lymphatic drainage of testes

Back 3

superficial and deep plexuses --> para-aortic

Front 4

lymphatic drainage of scrotum

Back 4

superficial inguinal

Front 5

lymphatic drainage of thigh (superficial)

Back 5

superficial inguinal

Front 6

lymphatic drainage of lateral side of the dorsum of the foot

Back 6

popliteal

Front 7

right lymphatic duct drains...

Back 7

right arm and right 1/2 of head

thoracic duct drains everything else

Front 8

red pulp of the spleen

Back 8

mechanical filtration of RBCs

reserve of monocytes

Front 9

white pulp of spleen

Back 9

active immune response via T cells (PALS) and B cells (follicles)

Front 10

splenic dysfunction

Back 10

decreased IgM --> decreased complement activation --> decreased C3b opsonization --> increased susceptibility to encapsulated organisms (S. pneumo, H. flu, Salmonella, N. meningitidis)

Front 11

When are T cells determined to be helper or cytotoxic

Back 11

during positive selection when pro-thymocytes interact with self MHC complexes

selected on MHC I --> CD8

MHC II --> CD4

Front 12

HLA for hemochromatosis

Back 12

HLA A3

Front 13

HLA B8

Back 13

Graves dz

Front 14

NK cells are enhanced by

Back 14

IL-12, INF alpha, INF beta

Front 15

superantigens Mx

Back 15

crosslinks B-region of TCR to MHC II on APCs

--> release of INF gamma from Th and subsequent release of IL-1, IL-6, and TNF alpha from macrophages

Front 16

endotoxin receptor

Back 16

CD14

Front 17

Th activation

Back 17

foreign body is phagocytosed by APC and antigen is presented on MHC II and recognized by TCR on Th cell

co-stimulation signal given by interaction between B7 and CD28

both are required

Front 18

Tc activation

Back 18

antigen presented on MHC I and recognized by TCR on Tc

IL-2 from Th cell activates Tc to kill virus infected cell

Front 19

what is required to stimulate immunologic memory

Back 19

peptide component

CD40 receptor on B cells and CD40 ligant on Th2 cells --> immunologic memory

Front 20

IL-10

Back 20

activates Th2 and inhibits Th1

so, this is pro-humoral and anti-cell mediated

Front 21

IL-12

Back 21

secreted by B cells and macrophages

activates NK and Th1 cells

Front 22

CD3

Back 22

Th or Tc cells

Front 23

CD40L

Back 23

Th cells

Front 24

CD28

Back 24

Th cells

Front 25

CD14

Back 25

macrophages

Front 26

CD16

Back 26

NK, binds Fc portion of IgG

Front 27

CD56

Back 27

NK cells

Front 28

what cells do not have MHC I

Back 28

mature RBCs

Front 29

primary opsonins

Back 29

C3b and IgG

Front 30

decay-accelerating factor (DAF) deficiency

Back 30

complement-mediated lysis of RBC --> PNH

Front 31

passive immunization is for...

Back 31

To Be Healed Rapidly

Tetanus
Botulinum
HBV
Rhabies

Front 32

what bacteria show antigen variation

Back 32

Salmonella (2 flagellan variants)

Borrelia (relapsing fever)

N. gonorrhea (pilus protein)

Front 33

Arthus reaction

Back 33

swelling and inflammation following tetanus vaccination

Type III hypersensitivity rxn

Front 34

anti-glutamate decarboxylase antibodies

Back 34

type 1 DBM

Front 35

anti-U1 RNP antibodies

Back 35

MCTD

Front 36

anti-Ro and anti-La antibodies

Back 36

Sjogrens

Front 37

anti-Scl-70 (anti-DNA topoisomerase I) antibodies

Back 37

Scleroderma (diffuse)

vs. anticentromere (scleroderma-CREST)

Front 38

cause of hyper IgM syndrome

Back 38

defective CD40L on Th cells --> inability to class switch

Front 39

Job's syndrome

Back 39

hyper IgE

Th cells fail to produce INF gamma --> inability of neutrophils to respond to chemotactic syndrome

FATED

coarse Facies
cold (non-inflamm.) staph Abscesses
retained primary Teeth
increased IgE
Derm problems (eczema)

Front 40

cyclosporine MoA

Back 40

inhibits calcineurin, thus preventing production of IL-2 and it's receptor

nephrotoxic (prevent with mannitol)

Front 41

Tacrolimus (FK506) MoA

Back 41

binds FK-binding protein and inhibits secretion of IL-2 and other cytokines

Front 42

Azothioprine MoA

Back 42

precursor to 6MP

interfers with nucleic acid synthesis

metabolized by xanthine oxidase, toxicity increases with allopurinol

Front 43

Muromonab-CD3 (OKT3) MoA

Back 43

monoclonal antibody to CD3 on T cell surface

blocks cellular interaction with CD3 responsible for T cell signal transduction

Front 44

Sirolimus (rapamycin) MoA

Back 44

binds mTOR and inhibits T cell proliferation in response to IL-2

Front 45

Mycophenolate mofetil MoA

Back 45

inhibits de novo guanine synthesis and inhibits lymphocyte production

Front 46

Daclizumab MoA

Back 46

monoclonal with high affinity to IL-2 on activated T cells