Usmle Biochem Molecular

Front 1

Inhibits ribonucleotide reductase

Back 1

Hydroxyurea

Front 2

Blocks de novo purine synthesis

Back 2

6-mercaptopurine

Front 3

Inhibits thymidylate reductase resulting in a decrease in dTMP

Back 3

5'- flourouracil

Front 4

Both of these drugs inhibits dihyrofolate reductase resulting in a decrease in production of dTMP

Back 4

Methotrexate and trimethoprim

Front 5

Findings of increased orotic acid in urine, megaloblastic anemia due to Inability to convert orotic acid to UMP due to a deficiency in these two enzymes. also what type of autosomal transferance is this under. What you treat this with?

Back 5

Orotic acid urea, due to a defect in orotic acid phophoribosyltransferase or ortidine 5'-phosphate decarboxylase, AR TRX: oral uridine administration

Front 6

Causes severe combined immunodeficiency disease due to this phenomena

Back 6

Adenosine deaminase deficiency causes an excess of ATP and dATP imbalnces nucleotide pool via feedback inhibition of ribonucleotide reductase preventing DNA synthesis and this dec. lymphpcyte count. A purine salvage deficiency

Front 7

This purine salvage deficiency presents as retardation, self-mutilation, aggression, hyperuricemia, gout and choreoathetosis. What is this and what is it's defect? What is the mode of inheritance?

Back 7

Lesche-Nyhan syndrome due to a lack of HGPRT, which normally converts hypoxanthine to IMP and guanine to GMP but the rxn is forced the opposite direction to both form xanthine then uric acid (hence the gout) x-linked recessive.