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44 Cards in this Set

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  • Back
antibiotic classes
Pen's
-G
-amox/amp
-ticar, piper, carba
-methcillin, naf, dicloxa

Cephs
Aztreonam
Imipenem/cilastin (meropenem)
Vanco

Aminoglycosides
Tetracyclines

Macrolides
Chloramphen
Clindamycin

sulfonamides
trimethoprim
fluoroquinolones
carbenicillin
P. Aeruginosa
amoxicillin
oral bioavailability
extended spectrum
HI, EC, Listeria, Proteus

p. colitis
methcilin
interstitial nephritis
pen
hemolytic anemia, hypersens
cefazolin
1st gen ceph
cephalexin
1st gen ceph
cefoxitin
2nd gen
cefaclor
2nd gen
cefuroxime
2nd gen
ceftriaxone
3rd gen
cefotaxime
3rd gen
ceftazidime
3rd gen
cefepime
4th gen
cefpiramide
4th gen
ceph toxicities
cross hypersens w/pen
nephrotox of aminoglyco's increased
disulfiram-like rxn w/ethanol
increases aminoglycoside toxicities
cephalosporins
aztreonam
monobactam
resistant to lactamases

G neg rods (kleb, pseudomon, serratia)
imipenem
w/ cilastin

enterobacter

CNS toxicity (sz) high dose
lactamase resistant
G pos cocci, G neg rods
meropenem
same as imipenem
vanco
cell wall mucopeptide

nephro
oto
thrombophlebitis

red man syndrome
protein synth inhibitors
aminoglycosides
tetracyclines

chloramphen
erythromy
clindamy
lincomy
streptomycin
aminoglycoside
gentamicin
aminoglycoside
amikacin
aminoglycoside
aminoglycosides
NOT ANAEROBES (need O2)
30s inhibit initiation complex

neo for bowel surg

nephro, oto, teratogen
tetracyclines
30s prevent attach aminoacyl-tRNA

vibrio, acne, chlamydia, urea_____, mycoplasma, pneumoniae, Tularemia, HPylori, Borrelia, Rickettsia

TERATOGEN

teeth discolor & bone
macrolides
erythromycin, azithromycin, clarithromycin

50s translocation
erythromycin
macrolide:
-50s translocation

URI, STD

increase serum conc of:
-theophyllines
-anticoagulants
chloramphenicol
50s peptidyltransferase

meningitis

anemia, aplastic anemia, gray baby (UDP glucuronyl transferase)
clindamycin
50s peptide bond formation

anaerobic inf (clostridium -except difficile, bacteroides)

PSEUDOMEMBRANOUS COLITIS
sulfonamides
all have sulf in name

PABA, dihydropteroate synthase

UTI

Hypersens,
G6PDh def get hemolysis
nephrotox
kernicterus in infant
displace drugs (warfarin) from albumin
trimethoprim
inhib dihydrofolate reductase

combo w/sulfonamides
-sequential block of folate synth (dihyropteroate synth, dihydrofolate reduct)

mega anemia, leukopen, granulocytopen
fluoroquinolones
___________floxacin

inhibit DNA gyrase (topoisom II)

UTI & GI gram negs

NOT in preg or c's(cart damage)
SUPERINFECTIONS
metronidazole
toxic metabolites in bact cell

giardia, entamoeba, trichomonas

H Pylori (triple tx):
add bismuth, amox (or tetra)

disulfarim w/ alc
polymixins
mix up membranes (osmotic properties)

resistant gram negs

neurotoxicity, ATN
resistance by lactamase cleavage
pen & ceph
resistance by acetylation, adenylation, phosphorylation
aminoglycos

chloramphenicol (acetylation only)
resistance by terminal D-ala replaced w/D-lac
vanco (decreases affinity)
resistance via methylation of rRNA near binding site
erythromycin
resistance by decrease uptake or increase transp out of cell
tetracycline
resistance via alter enzyme, decrease uptake or increase PABA synth
sulfonamides
nephrotoxic
aminoglycosides (ceph's increase effect)
-use aztreonam instead
vanco


Polymixin-ATN
contraindicated in preg
aminoglycosides (genta, neo, etc)
tetracyclines (teeth, bones)