Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/52

Click to flip

52 Cards in this Set

  • Front
  • Back
  • 3rd side (hint)
Class of H2 blockers:

which is a P-450 inhibitor and decreases renal excretion of creatinine?
"-tidines"


Cimetidine
(2) Proton pump inhibitors of the stomach
OmePRAZOLE

LansoPRAZOLE
drug that binds to ulcer base and helps Bicarb secretion reestablish pH in mucous
Bismuth
A prostaglandin analog that increases production and secretion of the gastric mucous barrier, decreasing acid production

Use (2)

(2) AE?
Misoprostol

use:
NSAID-induced peptic ulcers,
Maintain PDA

AE:
Diarrhea,
Abortifacient
Blocks M1 receptors on ECL cells to decrease histamine secretion and M3 receptors on parietal cells to decrease
H+ secretion

(2) AE
Muscarinic antagonist:

Pirenzepine

AE:
Bradycardia,
dry mouth
DOC for Crohn's Dz, that can cause a respiratory infection
Infliximab
DOC for Ulcerative colitis
(and can be used on Crohns)
Sulfa-salazine
DOC to control vomiting post-op and in patients undergoing chemotherapy

MOA?

(2) AE?
OndanSETRON

5-HT-3 (serotonin) Antagonist

[you will not vomit w/ ONDANSetron, so you can go ON DANCing]

AE:
Constipation,
HA
Antacid that causes constipation and hypophosphatemia
AluMINNUM hydroxide

[A MINIMUM amount of crap]
Antacid that causes diarrhea
Magnesium hydroxide

[Mg = Must Go to bathroom]
(3) examples of NSAIDs
(not ASA)

which closes a PDA?

MOA

(3) AE
Ibuprofen,
Naproxen,
Indomethacin (closes PDA)

MOA:
Reversibly inhibits COX-1 and COX-2

AE:
Renal damage,
Aplastic anemia,
GI upset
(2) selective COX-2 inhibitors

What is different?

Use?
CeleCOXIB,
ValdeCOXIB

-spares GI tract from corrosive effects

use:
RA and OA
NSAID that works in the CNS

how is it different from other NSAIDs?

AE?
Acetaminophen

Lacks anti-inflammatory property

AE:
Hepatic necrosis (depletes glutathione)
(4)* drugs to treat Gout


which are for acute gout?
(2)
I CAP:

Indomethacin (acute),

Colchicine (acute),

Allopurinol,

Probenecid
I CAP
Gout drug that depolymerize microtubules, impairing leukocyte chemotaxis and degranulation
Colchicine
Gout drug that inhibits the resorption of Uric acid
(and secretion of Penicillin)
Probenecid
Gout drug that inhibits Xanthine Oxidase, decreasing conversion of xanthine to uric acid
Allopurinol
Recombinant form of human TNF receptor that binds to
TNF-alpha

(3)* uses
Etanercept

uses (RAP):
Rheumatoid Arthritis,
Ankylosing Spondylitis,
Psoriasis
RAP
(3) uses of the TNF-a antibody: Infliximab
In flix my CAR:

Crohn's Dz,

Ankylosing Spondylitis,

RA
In flix my CAR
transplant drug that blocks differentiation and activation of T-cells (prevents IL-2 by inh Calcineurin)

(2) AE?
Cyclosporine

AE:
Nephrotoxic,
predisposes pt to infections and lymphoma
transplant drug that binds to FK-binding protein, inhibiting secretion of IL-2

Toxicity
(4)
Tacrolimus (FK506)

Toxicity:
Nephrotoxicity,
peripheral neuropathy,
HTN,
Pleural effusion
Antimetabolite derivative of 6-Mercaptopurine that interferes w/ metabolism and synthesis of nucleic acids; toxic to lymphocyte

(2) Uses?

AE
Azathioprine

uses:
Kidney transplant,
Autoimmune disorders

AE:
Bone marrow supression
Granulocyte Macrophage colony stimulating factor
Sargramostim

[Macro is the big SARG]
Granulocyte-colony stimulating factor
Filgrastim
beta-interferon is used for what Dx?
Multiple sclerosis
(2) drugs that treat thrombocytopenia?
Thrombopoietin,


Oprelvekin (IL-11)
what cytokine is used to treat Renal cell CA and Metastatic Melanoma?
Aldesleukin (IL-2)
Absorption of phosphate is reduced w/ what antacid?
Calcium carbonate
name (2) effective opiod anti-diarrheal that inhibits peristaltic movement, which can Tx diarrhea
Diphenoxylate,

Loperamide
what D2 antagonist is good as an anti-emetic and treats GERD?

MOA (2)
Metoclopramide

MOA:
D2 blocker at CTZ,
Inc LES pressure and Dec Pyloric sphinctor
Tx for portal systemic encephalopathy
Lactulose
what vitamin is teratogenic in large doses?
Vitamin A
Gel-like Drug that attaches to ulcer craters in GI and contains polyaluminum hydroxide
Sucralfate
Tx for Zollinger-Ellison
Omeprazole
what drug lowers GI secretion and is contraindicated in pregnant women?
Misoprostol
how does ASA increase gastric acidity?
inhibits PGE

(which is a parietal cell inhibitor)
patient has TIAs but cannot tolerate ASA; what would be an alternative?
Ticlopidine
Where does Furosemide work?
Ascending limb of Loop
what renal drug should be avoided w/ an aminoglycoside?
Furosemide

(both are ototoxic)
renal drug contrindicated in CHF
Mannitol

(pulls H2O to expand IV volume)
renal drug for Increased CSF (intracranial P) or intraocular pressure
Mannitol
(2) renal drugs that cause Acidosis
Acetazolamide,


K-Sparing diuretics
what renal drug causes a reduction of insulin release from the pancreas?
Thiazides
what supresses the release of ADH?
Alcohol
what renal drug causes acute gout?
Furosemide
Tx for Nephrogenic DI
Thiazides
what renal drug decreases the excretion of Cl ions?
Acetazolamide
drug used to Tx:
glaucoma, urinary alkalinization, Met Alkalosis and altitude sickness
Acetazolamide
MOA of Terazosin
Alpha-BLOCKER
what renal drug class can decrease serum calcium?
Loop diuretics

(may lead to HypoC)
what Loop diuretic can be used as an anti-edemic in patients w/ gout?
Ethacrynic acid
AE of Furosemide
(6)
OH DANG!:

Ototoxicity,
HypoK,

Dehydration,
Allergic Rxn (sulfa),
Nephritis (Interstitial),
Gout