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52 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Class of H2 blockers:
which is a P-450 inhibitor and decreases renal excretion of creatinine? |
"-tidines"
Cimetidine |
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(2) Proton pump inhibitors of the stomach
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OmePRAZOLE
LansoPRAZOLE |
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drug that binds to ulcer base and helps Bicarb secretion reestablish pH in mucous
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Bismuth
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A prostaglandin analog that increases production and secretion of the gastric mucous barrier, decreasing acid production
Use (2) (2) AE? |
Misoprostol
use: NSAID-induced peptic ulcers, Maintain PDA AE: Diarrhea, Abortifacient |
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Blocks M1 receptors on ECL cells to decrease histamine secretion and M3 receptors on parietal cells to decrease
H+ secretion (2) AE |
Muscarinic antagonist:
Pirenzepine AE: Bradycardia, dry mouth |
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DOC for Crohn's Dz, that can cause a respiratory infection
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Infliximab
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DOC for Ulcerative colitis
(and can be used on Crohns) |
Sulfa-salazine
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DOC to control vomiting post-op and in patients undergoing chemotherapy
MOA? (2) AE? |
OndanSETRON
5-HT-3 (serotonin) Antagonist [you will not vomit w/ ONDANSetron, so you can go ON DANCing] AE: Constipation, HA |
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Antacid that causes constipation and hypophosphatemia
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AluMINNUM hydroxide
[A MINIMUM amount of crap] |
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Antacid that causes diarrhea
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Magnesium hydroxide
[Mg = Must Go to bathroom] |
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(3) examples of NSAIDs
(not ASA) which closes a PDA? MOA (3) AE |
Ibuprofen,
Naproxen, Indomethacin (closes PDA) MOA: Reversibly inhibits COX-1 and COX-2 AE: Renal damage, Aplastic anemia, GI upset |
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(2) selective COX-2 inhibitors
What is different? Use? |
CeleCOXIB,
ValdeCOXIB -spares GI tract from corrosive effects use: RA and OA |
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NSAID that works in the CNS
how is it different from other NSAIDs? AE? |
Acetaminophen
Lacks anti-inflammatory property AE: Hepatic necrosis (depletes glutathione) |
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(4)* drugs to treat Gout
which are for acute gout? (2) |
I CAP:
Indomethacin (acute), Colchicine (acute), Allopurinol, Probenecid |
I CAP
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Gout drug that depolymerize microtubules, impairing leukocyte chemotaxis and degranulation
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Colchicine
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Gout drug that inhibits the resorption of Uric acid
(and secretion of Penicillin) |
Probenecid
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Gout drug that inhibits Xanthine Oxidase, decreasing conversion of xanthine to uric acid
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Allopurinol
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Recombinant form of human TNF receptor that binds to
TNF-alpha (3)* uses |
Etanercept
uses (RAP): Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriasis |
RAP
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(3) uses of the TNF-a antibody: Infliximab
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In flix my CAR:
Crohn's Dz, Ankylosing Spondylitis, RA |
In flix my CAR
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transplant drug that blocks differentiation and activation of T-cells (prevents IL-2 by inh Calcineurin)
(2) AE? |
Cyclosporine
AE: Nephrotoxic, predisposes pt to infections and lymphoma |
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transplant drug that binds to FK-binding protein, inhibiting secretion of IL-2
Toxicity (4) |
Tacrolimus (FK506)
Toxicity: Nephrotoxicity, peripheral neuropathy, HTN, Pleural effusion |
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Antimetabolite derivative of 6-Mercaptopurine that interferes w/ metabolism and synthesis of nucleic acids; toxic to lymphocyte
(2) Uses? AE |
Azathioprine
uses: Kidney transplant, Autoimmune disorders AE: Bone marrow supression |
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Granulocyte Macrophage colony stimulating factor
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Sargramostim
[Macro is the big SARG] |
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Granulocyte-colony stimulating factor
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Filgrastim
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beta-interferon is used for what Dx?
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Multiple sclerosis
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(2) drugs that treat thrombocytopenia?
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Thrombopoietin,
Oprelvekin (IL-11) |
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what cytokine is used to treat Renal cell CA and Metastatic Melanoma?
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Aldesleukin (IL-2)
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Absorption of phosphate is reduced w/ what antacid?
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Calcium carbonate
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name (2) effective opiod anti-diarrheal that inhibits peristaltic movement, which can Tx diarrhea
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Diphenoxylate,
Loperamide |
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what D2 antagonist is good as an anti-emetic and treats GERD?
MOA (2) |
Metoclopramide
MOA: D2 blocker at CTZ, Inc LES pressure and Dec Pyloric sphinctor |
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Tx for portal systemic encephalopathy
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Lactulose
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what vitamin is teratogenic in large doses?
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Vitamin A
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Gel-like Drug that attaches to ulcer craters in GI and contains polyaluminum hydroxide
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Sucralfate
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Tx for Zollinger-Ellison
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Omeprazole
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what drug lowers GI secretion and is contraindicated in pregnant women?
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Misoprostol
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how does ASA increase gastric acidity?
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inhibits PGE
(which is a parietal cell inhibitor) |
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patient has TIAs but cannot tolerate ASA; what would be an alternative?
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Ticlopidine
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Where does Furosemide work?
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Ascending limb of Loop
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what renal drug should be avoided w/ an aminoglycoside?
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Furosemide
(both are ototoxic) |
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renal drug contrindicated in CHF
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Mannitol
(pulls H2O to expand IV volume) |
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renal drug for Increased CSF (intracranial P) or intraocular pressure
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Mannitol
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(2) renal drugs that cause Acidosis
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Acetazolamide,
K-Sparing diuretics |
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what renal drug causes a reduction of insulin release from the pancreas?
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Thiazides
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what supresses the release of ADH?
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Alcohol
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what renal drug causes acute gout?
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Furosemide
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Tx for Nephrogenic DI
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Thiazides
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what renal drug decreases the excretion of Cl ions?
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Acetazolamide
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drug used to Tx:
glaucoma, urinary alkalinization, Met Alkalosis and altitude sickness |
Acetazolamide
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MOA of Terazosin
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Alpha-BLOCKER
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what renal drug class can decrease serum calcium?
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Loop diuretics
(may lead to HypoC) |
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what Loop diuretic can be used as an anti-edemic in patients w/ gout?
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Ethacrynic acid
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AE of Furosemide
(6) |
OH DANG!:
Ototoxicity, HypoK, Dehydration, Allergic Rxn (sulfa), Nephritis (Interstitial), Gout |
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