Usmle 1 Pharm Abx

Front 1

(6)* bugs that Ampicillin/Amoxicillin is good for destroying

Back 1

A/A HELPS kill Enterococci:

H.influenzae,
E.coli,
Listeria,
Proteus,
Salmonella,
Enterococci

Hint 1

A/A HELPS kill Enterococci

Front 2

which has greater oral bioavailability: Ampicillin or Amoxicillin?

Back 2

AmOxicillin = Oral

Front 3

what do the extended spectrum penicillins
(Ticarcillin, Carbenicillin, Piperacillin) work on?

Back 3

TCP:

Takes Care of Pseudomonas

Front 4

(3)* bugs for first generation cephalosporins

Back 4

PEcK:

Proteus,
E.coli,
Klebsiella

Hint 4

PEcK

Front 5

(7)* bugs for second generation cephalosporins

Back 5

HEN PEcKS:

H.influenza,
Enterobacter,
Neisseria spp.,
Proteus,
E.coli,
Klebsiella,
Serratia marc.

Front 6

what do the third and fourth generation cephalosporins have good activity against?
(2)

Back 6

Pseudomonas,

Gram-negatives

Front 7

what is co-administered w/ Imipenem?

Back 7

Impenem - the kill is LASTIN w/ ciLASTIN:

Cilastin

Front 8

Drug that causes "red man syndrome" (diffuse flushing)

Back 8

Vacomycin

(D-ala)

Front 9

(4)* AE of Vancomycin

Back 9

I READ there's NOT many problems w/ Vanco:

RED man syndrome,
Nephrotoxicity,
Ototoxixity,
Thrombophlebitis

Hint 9

I READ there's NOT many problems w/ Vanco

Front 10

what are the 30 (2) and 50 (3) ribosomes inhibitors?

which is bactericidal?

Back 10

"Buy AT 30, CELL at 50":

30:
A - Aminoglycosides (bactericidal)
T - Tetracycline

50:
C - Chloramphenicol
E - Erythromycin
L - Lincomycin
L - cLindamycin

Front 11

(5)* types of Aminoglycosides

(3)* AE

Back 11

"Mean (Amino) GNATS canNOT kill anaerobes":

Gentamicin,
Neomycin,
Amikacin,
Tobramycin,
Streptomycin

AE:
Nephrotoxicity,
Ototoxicity,
Teratogen

Hint 11

Mean (Amino) GNATS canNOT kill anaerobes

Front 12

what Tetracycline is a ADH antagonist?

Back 12

Demeclocycline

Front 13

what Tetracycline is good for pt w/ renal failure?

Back 13

Doxycycline

Front 14

(10) Tetracycline bugs

Back 14

VACUUM THe BedRoom:

Vibrio cholera, Acne, Chlamydia, Ureaplasma, M.pneumonia,

Tularemia, H.pylori,

Borrelia (Lyme), Rickettsia

Front 15

AE of Tetracycline
(2)

Back 15

Inhibits bone growth in kids,

discolors teeth

Front 16

which drug class binds to the 23s rRNA of the 50s ribosomal unit?

Back 16

Macrolides

(erythromycin)

Front 17

MCC of non-compliance in Macrolides

Back 17

GI upset

Front 18

what drug is good against H.influenza, N.meningitis and S.pneumonia types of Meningitis?

(2) AE

Back 18

Chloramphenicol


AE:
Gray baby syndrome,
Anemia

Front 19

drug that treats C.perfringes only to possibly get the AE of C.difficile (pseudomembraneous colitis)

Back 19

Clindamycin

Front 20

Abx that causes hemolysis in G6PD deficeint patients

other AE (2)

MOA

Back 20

Sulfonamides

AE:
Nephrotoxicity,
Kernicterus in infants

MOA: blocks Dihydropteroate synthase (PABA step 1)

Front 21

Abx that inhibits DHF


AE?

Back 21

Trimethoprim (TMP)

AE:
(Treats Marrow Poorly)

works w/ SMX

Front 22

Abx that inhibits DNA gyrase
(topoisomerase II)

(2) AE

Back 22

Fluoroquinolones

(AE) fluoroquinoLONES is bad for the BONES:
damage Cartilage,
Tendonitis

Front 23

Abx that forms toxic metabolites in bacterial cell

(3) uses

AE (2)

Back 23

Metronidazole

use ("GET on the Metro"):
Giardia / Gardnerella vaginalis,
Entamoeba,
Trichomonas

AE: Disulfiram-effects w/ alcohol,
metallic taste

Front 24

Abx that binds to cell membranes to disrupt their osmotic properties

AE (2)

Back 24

Polymixins

[MYXins MIX up the membranes]

AE:
Neurotoxicity,
Acute tubular necrosis

Front 25

(5)* Anti-TB drugs

Back 25

INH-SPIRE (inspire):

Streptomycin,
Pyrazinamide,
INH,
Rifampin,
Ethambutol

Hint 25

INH-SPIRE (inspire):

Front 26

drug that decreases synthesis of mycolic acids causing an inhibition of cell wall synthesis, and is used alone as the TB prophylaxis

(4) AE

Back 26

Isoniazid (INH)

AE (INHH):
Immuno SLE-like syndrome
Neurotoxicity,
Hepatotoxicity,
Hemolysis in G6PD

Front 27

what are the (4) R's of Rifampin

Back 27

RNA polymerase inhibitor,
Revs up P-450,
Red/Orange body fluids,
Rapid resistance if used alone

Front 28

Prophylaxis drug:

Meningococcal infection

Back 28

Rifampin

Front 29

Prophylaxis drug:

Gonorrhea

Back 29

Ceftriaxone

Front 30

Prophylaxis drug:

Syphillis

Back 30

Penacillin G

Front 31

Prophylaxis drug:

Hx of recurrent UTI

Back 31

TMP-SMX

Front 32

Prophylaxis drug:

PCP

Back 32

TMP-SMX

Front 33

prophylaxis against Endocarditis w/ dental, GU or GI procedures

Back 33

Penicillins

Front 34

antifungal that binds ergosterol to tear hole in the membrane

Back 34

Amphotericin B

[amphoTEARicin = TEARs holes]

Front 35

antifungal that binds to ergosterol and is only used topically or as a mouth rinse

use?

Back 35

Nystatin

Candidiasis (oral and vaginal)

Front 36

class of anti-fungals that inhibit ergosterol synthesis

(2) AE

Back 36

"-AZOLEs"

[AZOLE inhibits ergosterOLE]

AE:
Gynecomastia,
Inhibits P-450

Front 37

Drug for Tinea and ringworm that interferes w/ bug microtubule synthesis*

Back 37

Griseofulvin

[GRISwalds are full of Tinea and ringworm]

Hint 37

GRISwalds are full of Tinea and ringworm

Front 38

drug that inhibits cell wall synthesis and is only for Aspergillosis

Back 38

Caspofungin

[CAS-PERgillosis the friendly fungal ghost]

Hint 38

CAS-PERgillosis the friendly fungal ghost

Front 39

drug that inhibits squalene epoxidase and treats onychomycosis

Back 39

Terbinafine

[the guys in TURBINS have bad toenails]

Front 40

anti-viral that blocks penetration and uncoating*

(2) uses

AE?

Back 40

Amantadine

[A MAN To DINE takes off his COAT]

Amatadine blocks Influ A and rubellA

AE:
cerebellA (ataxia, slurred speech)

Hint 40

A MAN To DINE takes off his COAT

Front 41

inhibits influenza neuraminidase for A and B

(2)

Back 41

Zanamivir,

Oseltamivir

Front 42

anti-viral that inhibits synthesis of guanine nucleotides by inhibiting IMP-DH

(2) uses

Back 42

Ribavirin

use:

RSV,
Hep-C

Front 43

anti-viral that binds to the pyrophosphate binding site of DNA polymerase

use?

Back 43

Foscarnet

[FOScarnet = pyroFOSphate binder]

use:
CMV retinitis and when either Ganciclovir or Acyclovir fail

Front 44

Drugs that are Reverse Transcriptase inhibitor Nucleotides?

Non-Nucleotides?

Back 44

Nucleotides:
"-VUDINEs"
(ZidoVUDINE: AZT)

Non-Nucleotides:
"-AVIR-"
(nAVIRapine)

Front 45

HIV Protease inhibitors*

Back 45

"-NAVIRs"

[Never (navir) Tease a Pro]
(pro-tease)

Hint 45

Never (navir) Tease a Pro

Front 46

what is the drug specific for latent hypnozoite forms of malaria (P.vivex and ovale)

Back 46

Primaquine

Front 47

anti-parasitic against Chagas and T.cruzi

Back 47

Nifurtimox

[NiceFURry CHAG carpet To CRUZE with]

Front 48

DOC for pinworm and whipworm infections

Back 48

Mebendazole

Front 49

DOC for Giant roundworm (Ascaris) and hookworm infections

Back 49

Pyrantel Pamoate

Front 50

Abx to avoid in Pregnancy
(9)*

Back 50

SAFE Moms Take Really Good Care:

Sulfonamides, Aminoglycosides, FQ, Erythromycin,
Metronidazole, Tetracycline, Ribivirin, Griseofulvin, Chloramphenicol

Hint 50

SAFE Moms Take Really Good Care

Front 51

(5)* bugs that have Penicillin G as the DOC

Back 51

VAMPS:

s.Viridians,
Actinomyces,
n.Meningitis,
s.Pyogens,
Syphilis

Hint 51

VAMPS

Front 52

(4)* bugs that have FQ as the DOC

Back 52

PACK the F-up:

Proteus UTI,
Anthrax,
Campylobacter,
Klebsiella UTI

Hint 52

PACK the F-up

Front 53

(3)* bugs that have Erythromycin as the DOC

Back 53

Err...THRO-MY LAB a bone:

Legionella,
Atypical (Mycoplasma) pneumonia,
B.pertussis (whooping cough)

Hint 53

Err...THRO-MY LAB a bone

Front 54

(3)* bugs that have 3rd Generation cephalosporin as the DOC

Back 54

cephalosporKIN:

Klebsiella pneumonia,
h.Influenza (pneu or mening),
N.gonorrhea [Ceftriaxone]

Hint 54

cephalosporKIN

Front 55

DOC for Yersinia

Back 55

Streptomycin

Front 56

DOC for Trichomonas

Back 56

Metronidazole

Front 57

(4)* bugs that have TMP-SMX as the DOC

Back 57

NO WHIPping SALMON SHIt in this TeMP:

Nocardia pneu,
t.Whippelii (Whipple's Dz),
Salmonella typhii,
Shigella

Hint 57

NO WHIPping SALMON SHIt in this TeMP

Front 58

DOC for chronic candidiasis

Back 58

Fluconazole (or Ketoconazole)

Front 59

which anti-worm inhibits the worm's neruomuscular transmission?

Back 59

Pyrantel Pamoate

Front 60

AE of GI and esophageal ulcerations and pancreatitis

Back 60

Dideoxycytidine

Front 61

(4)* Penicillin drugs that are able to work against b-lactamase-positive bugs

Back 61

The Penacillin MONCs:

Methicillin,
Oxacillin,
Naficillin,
Cloxacillin (or Diclox-)

Hint 61

The Penacillin MONCs

Front 62

(2) inhibitors of FQ

Back 62

Antacids,

Iron

Front 63

MOA of Acyclovir and Ganciclovir

Back 63

Inh viral DNA synthesis

Front 64

TB drug that can cause red-green color blindness

Back 64

Ethambutol