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64 Cards in this Set

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(6)* bugs that Ampicillin/Amoxicillin is good for destroying
A/A HELPS kill Enterococci:

H.influenzae,
E.coli,
Listeria,
Proteus,
Salmonella,
Enterococci
A/A HELPS kill Enterococci
which has greater oral bioavailability: Ampicillin or Amoxicillin?
AmOxicillin = Oral
what do the extended spectrum penicillins
(Ticarcillin, Carbenicillin, Piperacillin) work on?
TCP:

Takes Care of Pseudomonas
(3)* bugs for first generation cephalosporins
PEcK:

Proteus,
E.coli,
Klebsiella
PEcK
(7)* bugs for second generation cephalosporins
HEN PEcKS:

H.influenza,
Enterobacter,
Neisseria spp.,
Proteus,
E.coli,
Klebsiella,
Serratia marc.
what do the third and fourth generation cephalosporins have good activity against?
(2)
Pseudomonas,

Gram-negatives
what is co-administered w/ Imipenem?
Impenem - the kill is LASTIN w/ ciLASTIN:

Cilastin
Drug that causes "red man syndrome" (diffuse flushing)
Vacomycin

(D-ala)
(4)* AE of Vancomycin
I READ there's NOT many problems w/ Vanco:

RED man syndrome,
Nephrotoxicity,
Ototoxixity,
Thrombophlebitis
I READ there's NOT many problems w/ Vanco
what are the 30 (2) and 50 (3) ribosomes inhibitors?

which is bactericidal?
"Buy AT 30, CELL at 50":

30:
A - Aminoglycosides (bactericidal)
T - Tetracycline

50:
C - Chloramphenicol
E - Erythromycin
L - Lincomycin
L - cLindamycin
(5)* types of Aminoglycosides

(3)* AE
"Mean (Amino) GNATS canNOT kill anaerobes":

Gentamicin,
Neomycin,
Amikacin,
Tobramycin,
Streptomycin

AE:
Nephrotoxicity,
Ototoxicity,
Teratogen
Mean (Amino) GNATS canNOT kill anaerobes
what Tetracycline is a ADH antagonist?
Demeclocycline
what Tetracycline is good for pt w/ renal failure?
Doxycycline
(10) Tetracycline bugs
VACUUM THe BedRoom:

Vibrio cholera, Acne, Chlamydia, Ureaplasma, M.pneumonia,

Tularemia, H.pylori,

Borrelia (Lyme), Rickettsia
AE of Tetracycline
(2)
Inhibits bone growth in kids,

discolors teeth
which drug class binds to the 23s rRNA of the 50s ribosomal unit?
Macrolides

(erythromycin)
MCC of non-compliance in Macrolides
GI upset
what drug is good against H.influenza, N.meningitis and S.pneumonia types of Meningitis?

(2) AE
Chloramphenicol


AE:
Gray baby syndrome,
Anemia
drug that treats C.perfringes only to possibly get the AE of C.difficile (pseudomembraneous colitis)
Clindamycin
Abx that causes hemolysis in G6PD deficeint patients

other AE (2)

MOA
Sulfonamides

AE:
Nephrotoxicity,
Kernicterus in infants

MOA: blocks Dihydropteroate synthase (PABA step 1)
Abx that inhibits DHF


AE?
Trimethoprim (TMP)

AE:
(Treats Marrow Poorly)

works w/ SMX
Abx that inhibits DNA gyrase
(topoisomerase II)

(2) AE
Fluoroquinolones

(AE) fluoroquinoLONES is bad for the BONES:
damage Cartilage,
Tendonitis
Abx that forms toxic metabolites in bacterial cell

(3) uses

AE (2)
Metronidazole

use ("GET on the Metro"):
Giardia / Gardnerella vaginalis,
Entamoeba,
Trichomonas

AE: Disulfiram-effects w/ alcohol,
metallic taste
Abx that binds to cell membranes to disrupt their osmotic properties

AE (2)
Polymixins

[MYXins MIX up the membranes]

AE:
Neurotoxicity,
Acute tubular necrosis
(5)* Anti-TB drugs
INH-SPIRE (inspire):

Streptomycin,
Pyrazinamide,
INH,
Rifampin,
Ethambutol
INH-SPIRE (inspire):
drug that decreases synthesis of mycolic acids causing an inhibition of cell wall synthesis, and is used alone as the TB prophylaxis

(4) AE
Isoniazid (INH)

AE (INHH):
Immuno SLE-like syndrome
Neurotoxicity,
Hepatotoxicity,
Hemolysis in G6PD
what are the (4) R's of Rifampin
RNA polymerase inhibitor,
Revs up P-450,
Red/Orange body fluids,
Rapid resistance if used alone
Prophylaxis drug:

Meningococcal infection
Rifampin
Prophylaxis drug:

Gonorrhea
Ceftriaxone
Prophylaxis drug:

Syphillis
Penacillin G
Prophylaxis drug:

Hx of recurrent UTI
TMP-SMX
Prophylaxis drug:

PCP
TMP-SMX
prophylaxis against Endocarditis w/ dental, GU or GI procedures
Penicillins
antifungal that binds ergosterol to tear hole in the membrane
Amphotericin B

[amphoTEARicin = TEARs holes]
antifungal that binds to ergosterol and is only used topically or as a mouth rinse

use?
Nystatin

Candidiasis (oral and vaginal)
class of anti-fungals that inhibit ergosterol synthesis

(2) AE
"-AZOLEs"

[AZOLE inhibits ergosterOLE]

AE:
Gynecomastia,
Inhibits P-450
Drug for Tinea and ringworm that interferes w/ bug microtubule synthesis*
Griseofulvin

[GRISwalds are full of Tinea and ringworm]
GRISwalds are full of Tinea and ringworm
drug that inhibits cell wall synthesis and is only for Aspergillosis
Caspofungin

[CAS-PERgillosis the friendly fungal ghost]
CAS-PERgillosis the friendly fungal ghost
drug that inhibits squalene epoxidase and treats onychomycosis
Terbinafine

[the guys in TURBINS have bad toenails]
anti-viral that blocks penetration and uncoating*

(2) uses

AE?
Amantadine

[A MAN To DINE takes off his COAT]

Amatadine blocks Influ A and rubellA

AE:
cerebellA (ataxia, slurred speech)
A MAN To DINE takes off his COAT
inhibits influenza neuraminidase for A and B

(2)
Zanamivir,

Oseltamivir
anti-viral that inhibits synthesis of guanine nucleotides by inhibiting IMP-DH

(2) uses
Ribavirin

use:

RSV,
Hep-C
anti-viral that binds to the pyrophosphate binding site of DNA polymerase

use?
Foscarnet

[FOScarnet = pyroFOSphate binder]

use:
CMV retinitis and when either Ganciclovir or Acyclovir fail
Drugs that are Reverse Transcriptase inhibitor Nucleotides?

Non-Nucleotides?
Nucleotides:
"-VUDINEs"
(ZidoVUDINE: AZT)

Non-Nucleotides:
"-AVIR-"
(nAVIRapine)
HIV Protease inhibitors*
"-NAVIRs"

[Never (navir) Tease a Pro]
(pro-tease)
Never (navir) Tease a Pro
what is the drug specific for latent hypnozoite forms of malaria (P.vivex and ovale)
Primaquine
anti-parasitic against Chagas and T.cruzi
Nifurtimox

[NiceFURry CHAG carpet To CRUZE with]
DOC for pinworm and whipworm infections
Mebendazole
DOC for Giant roundworm (Ascaris) and hookworm infections
Pyrantel Pamoate
Abx to avoid in Pregnancy
(9)*
SAFE Moms Take Really Good Care:

Sulfonamides, Aminoglycosides, FQ, Erythromycin,
Metronidazole, Tetracycline, Ribivirin, Griseofulvin, Chloramphenicol
SAFE Moms Take Really Good Care
(5)* bugs that have Penicillin G as the DOC
VAMPS:

s.Viridians,
Actinomyces,
n.Meningitis,
s.Pyogens,
Syphilis
VAMPS
(4)* bugs that have FQ as the DOC
PACK the F-up:

Proteus UTI,
Anthrax,
Campylobacter,
Klebsiella UTI
PACK the F-up
(3)* bugs that have Erythromycin as the DOC
Err...THRO-MY LAB a bone:

Legionella,
Atypical (Mycoplasma) pneumonia,
B.pertussis (whooping cough)
Err...THRO-MY LAB a bone
(3)* bugs that have 3rd Generation cephalosporin as the DOC
cephalosporKIN:

Klebsiella pneumonia,
h.Influenza (pneu or mening),
N.gonorrhea [Ceftriaxone]
cephalosporKIN
DOC for Yersinia
Streptomycin
DOC for Trichomonas
Metronidazole
(4)* bugs that have TMP-SMX as the DOC
NO WHIPping SALMON SHIt in this TeMP:

Nocardia pneu,
t.Whippelii (Whipple's Dz),
Salmonella typhii,
Shigella
NO WHIPping SALMON SHIt in this TeMP
DOC for chronic candidiasis
Fluconazole (or Ketoconazole)
which anti-worm inhibits the worm's neruomuscular transmission?
Pyrantel Pamoate
AE of GI and esophageal ulcerations and pancreatitis
Dideoxycytidine
(4)* Penicillin drugs that are able to work against b-lactamase-positive bugs
The Penacillin MONCs:

Methicillin,
Oxacillin,
Naficillin,
Cloxacillin (or Diclox-)
The Penacillin MONCs
(2) inhibitors of FQ
Antacids,

Iron
MOA of Acyclovir and Ganciclovir
Inh viral DNA synthesis
TB drug that can cause red-green color blindness
Ethambutol