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7 Cards in this Set
- Front
- Back
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Acidic Drug Dissociation Equation
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HA <--/--> H+ + A- (Protonated in anion form)
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Basic Drug Dissociation Equation
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BH+ <--/--> H+ + B (Protonated in drug form)
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pKa definition
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pKa is the pH at which HA = A- and BH+ = B
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What happens if the pH is LOWER than the pKa
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More protonated form (HA or BH+) --> basic drugs get trapped because they are charged
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What happens if pH is HIGHER than the pKa
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More NONprotonated form (A- or B) --> acidic drugs get trapped because they are charged
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How do you treat an acidic drug OD?
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With Sodium Bicarb --> raises urine pH, trapping acidic drug in basic urine
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How do you treat a basic drug OD?
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With Ammonium Chloride --> decreases urine pH, trapping basic drugs in acidic urine
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