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12 Cards in this Set
- Front
- Back
What determines Plasma volume?
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Plasma Na concentration
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What is Na balance?
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The process by which the kidney matches Na ingestion and excretion
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What is Increased Sodium in the urine called?
Why would this happen physiologically? |
Natriuresis
To decreas ECF volume |
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What detects changes in ECF volume?
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Baroreceptors
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1) What are the two types of Baroreceptors?
2) Where are they found? 3) Which nerve do they utilise? |
1) High and Low pressure baroreceptors
2) H: carotid sinus and aortic arch L: Atria & pulmonary vasculature 3) Vagues (Glossophryngeal: High pressure BRs) |
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How does the body respond to ECF expansion
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ANP release decreases Blood volume and Na reabsorption
Initial increase in GFR decreases Na reabsorption |
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How does the body respond to ECF contraction
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RAAS and SNS increase Na reabsorption
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What type of reabsorption occurs in the PCT.
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Isosmotic
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Describe and explain the changes in osmolarity of the filtrate as is passes through the LoH
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-Start: isosmotic
-Descending limb: looses water; become hypertonic/hyperosmotic -Ascending: Salts actively pumped out; becomes hyposmotic/hypotonic |
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1) What channels are present in the Loh
2) What condition is a loss of function of these transporters 3) what does it lead to |
1) NKCC2;ROMK;Na-K-ATPase
2) Barter's syndrome 3) Loss of Na in urine and hypokalaemia |
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1) what reabsorption happens in the DCT
2)What transporters are present 3) What drug affects these? |
1)Active transport of Na, K and Ca
2) NCC, ENaC 3) Thiazide diuretics (NCC); Amiloride (ENaC) |
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1) What two types of cells are found in the CD
2) What do they do? |
1) Principle cells; Type B intercalated cells
2) P.cells: Na reabsorption via ENaC B.cells: Secrete HCO3 |