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20 Cards in this Set
- Front
- Back
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What compartment of the cell does the 1st reaction of the urea cycle occur? |
mitochondria |
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What is the product of the reaction of CO2 with NH3 ? |
Carbamoyl phosphate synthetase (CPS 1) |
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What are the 2 requirements for the function of the carbamoyl phosphate synthetase? |
1) 2 ATP 2) N-acetyl glutamate (allosteric activator) |
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What does carbamoyl phosphate react with to form L-citrulline? |
L-ornithine |
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What is the enzyme that facilitates the reaction of carbamoyl phosphate with L-ornithine? |
ornithine transcarbamoylase |
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What is the fate of L-citrulline after production in the mitochondrial matrix? |
transported to the cytosol |
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What does L-citrulline react with in the cytosol and what is the product of this reaction? |
1) reacts with : L-aspartate 2) product : arginosuccinate |
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What is the enzyme which facilitates the reaction of L-citrulline with L-aspartate? |
1) enzyme : arginosuccinate synthetase |
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What is the fate of arginosuccinate? |
converted to L-arginine |
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What is the name of the enzyme that converts arginosuccinate to L-arginine? |
arginosuccinate lyase works by lysis reaction using H20 |
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What is the important by product of the arginosuccinate lyase reaction? |
fumarate |
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what is the fate of fumatate? |
1) hydrated to malate 2) converted to oxaloacetate in a dehydrogenase reaction which uses NAD+ as a coenzyme |
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Which substrate of the urea cycle pathway is oxaloacetate regenerated to? |
L-aspartate |
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What type of reaction converts oxaloacete to L-aspartate? |
transamination reaction |
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What substrate serves as the amine donor of the transamination reaction and what is it's product? |
substrate: glumatate |
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What enzyme converts L-arginine back to L-ornithine |
arginase |
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What is the product of the reaction which converts L-arginine to L-ornithine |
urea |
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What type of reaction is the one which converts L-arginine to L-ornithine? |
hydrolase reaction (uses H20) |
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What is the fate of cytosolic L-ornithine? |
enters mitochondrial matrix |
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In what tissue do all the reactions of the urea cycle occur? |
liver |
